Highly purified hMG achieves better pregnancy rates in IVF cycles but not ICSI cycles compared with recombinant FSH: A meta-analysis

Gynecological Endocrinology

Volumn 25, Issue 6, 2009, Pages 372-378

  Al Inany, Hesham G ^a,b   Abou Setta, Ahmed M ^c   Aboulghar, Mohamed A ^a,b   Mansour, Ragaa T ^a   Serour, Gamal I ^a  

^a Egyptian IVF ET Centre   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c Private Clinic   (Egypt)

Author keywords

FSH; HMG; IVF; Meta analysis; Ovulation stimulation

Indexed keywords

HUMAN MENOPAUSAL GONADOTROPIN; RECOMBINANT FOLLITROPIN;

ARTICLE; CLINICAL TRIAL; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; MENSTRUAL CYCLE; META ANALYSIS; MULTIPLE PREGNANCY; OOCYTE RETRIEVAL; OVARY HYPERSTIMULATION; PREGNANCY RATE; PRIORITY JOURNAL; PROBABILITY; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT RESPONSE;

FEMALE; FERTILITY AGENTS, FEMALE; FOLLICLE STIMULATING HORMONE, HUMAN; HUMANS; INFERTILITY, FEMALE; MENOTROPINS; PREGNANCY; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECOMBINANT PROTEINS; SPERM INJECTIONS, INTRACYTOPLASMIC;

EID: 70350582879     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590802630120     Document Type: Article

References (25)

1. Bassett RM, Driebergen R. Continued improvements in the quality and consistency of follitropin alfa, recombinant human FSH. Reprod Biomed Online 2005;10:169-177.
2. Wolfenson C, Groisman J, Couto AS, Hedenfalk M, Cortvrindt RG, Smitz JE, Jespersen S. Batch-to-batch consistency of human-derived gonadotrophin preparations compared with recombinant preparations. Reprod Biomed Online 2005;10:442-454.
3. Filicori M, Fazleabas AT, Huhtaniemi I, Licht P, Rao Ch V, Tesarik J, Zygmunt M. Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility. Fertil Steril 2005;84:275-284.
4. Platteau P, Andersen AN, Balen A, Devroey P, Sørensen P, Helmgaard L, Arce JC; Menopur Ovulation Induction (MOI) Study Group Similar ovulation rates, but different follicular development with highly purified menotrophin compared with recombinant FSH in WHO Group II anovulatory infertility: a randomized controlled study. Hum Reprod 2006;21:1798-1804.
5. Al-Inany HG, Abou-Setta AM, Aboulghar MA, Mansour RT, Serour GI. Efficacy and safety of human menopausal gonadotrophins versus recombinant FSH: a meta-analysis. Reprod Biomed Online 2008;16:81-88.
6. Coomarasamy A, Afnan M, Cheema D, Van Der Veen F, Bossuyt PM, Van Wely M. Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis. Hum Reprod 2008;23:310-315.
7. Platteau P, Smitz J, Albano C, Sørensen P, Arce JC, Devroey P. Exogenous luteinizing hormone activity may influence the treatment outcome in in vitro fertilization but not in intracytoplasmic sperm injection cycles. Fertil Steril 2004;81: 1401-1414.
8. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analysis. BMJ 2003;327:557-560.
9. Gavaghan DJ, Moore RA, McQuay HJ. An evaluation of homogeneity tests in meta-analyses in pain using simulations of individual patient data. Pain 2000;85:415-424.
10. Andersen AN, Devroey P, Arce JC. Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial. Hum Reprod 2006;21:3217-3227.
11. Bosch E, Vidal C, Crespo J, Simon C, Remohi A, Pellicer A. Highly purified HMG versus rec-FSH in GnRH antagonist cycles. Hum Reprod 2005;20(Suppl 1):i118 .
12. European and Israeli Study Group on Highly Purified Menotropin versus Recombinant Follicle-Stimulating Hormone Efficacy and safety of highly purified menotropin versus recombinant follicle-stimulating hormone in in vitro fertilization/intracytoplasmic sperm injection cycles: a randomized, comparative trial. Fertil Steril 2002;78:520-528.
13. Hompes PG, Broekmans FJ, Hoozemans DA, Schats R; FIRM Group. Effectiveness of highly purified human menopausal gonadotropin vs. recombinant follicle-stimulating hormone in first-cycle in vitro fertilization- intracytoplasmic sperm injection patients. Fertil Steril 2008;89:1685-1693.
14. Kilani Z, Dakkak A, Ghunaim S, Cognigni GE, Tabarelli C, Parmegiani L, Filicori M. A prospective, randomized, controlled trial comparing highly purified hMG with recombinant FSH in women undergoing ICSI: ovarian response and clinical outcomes. Hum Reprod 2003;18:1194-1199.
15. Strowitzki T. By treatment protocols: differences in treatment outcomes after antagonist downregulation. 5thWorld Congress on Ovulation Induction. Rome, Italy, September 13-15, 2007.
16. Zygmunt M, Herr F, Keller-Schoenwetter S, Kunzi-Rapp K, Mü nstedt K, Rao CV, Lang U, Preissner KT. Characterization of human chorionic gonadotropin as a novel angiogenic factor. J Clin Endocrinol Metab 2002;87:5290-5296.
17. Lévy DP, Navarro JM, Schattman GL, Davis OK, Rosenwaks Z. The role of LH in ovarian stimulation: exogenous LH: let's design the future. Hum Reprod 2000;15:2258-2265.
18. Kolibianakis EM, Zikopoulos K, Schiettecatte J, Smitz J, Tournaye H, Camus M, Van Steirteghem AC, Devroey P. Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF. Hum Reprod 2004;19:2490-2496.
19. Mansour RT, Aboulghar MA, Serour GI, Abbass AM. Co-culture of human pronucleate oocytes with their cumulus cells. Hum Reprod 1994;9:1727-1729.
20. Hassan HA. Cumulus cell contribution to cytoplasmic maturation and oocyte developmental competence in vitro. J Assist Reprod Genet 2001;18:539-543.
21. Taylor TH, Wright G, Jones-Colon S, Mitchell-Leef D, Kort HI, Nagy ZP. Comparison of ICSI and conventional IVF in patients with increased oocyte immaturity. Reprod Biomed Online 2008;17:46-52.
22. Parikh FR, Nadkarni SG, Naik NJ, Naik DJ, Uttamchandani SA. Cumulus coculture and cumulus-aided embryo transfer increases pregnancy rates in patients undergoing in vitro fertilization. Fertil Steril 2006;86:839-847.
23. Huang FJ, Huang HW, Lan KC, Kung FT, Lin YC, Chang HW, Chang SY. The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability. J Assist Reprod Genet 2002;19:555-560.
24. Van Wely M, Westergaard LG, Bossuyt PM, Van der Veen F. Human menopausal gonadotropin versus recombinant follicle stimulation hormone for ovarian stimulation in assisted reproductive cycles. Cochrane Database Syst Rev 2003;(1): CD003973.
25. Al-Inany HG, Abou-Setta AM, Aboulghar M. Gonadotrophin- releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev 2006;(3):CD001750.