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Volumn 4, Issue 4, 2009, Pages 549-558

Neurobiologic Mechanisms in Chronic Insomnia

Author keywords

ARAS; Homeostasis; Inhibition of wakefulness; Insomnia; Neurobiology; VLPO

Indexed keywords

11 HYDROXYCORTICOSTEROID; 4 AMINOBUTYRIC ACID; ACETYLCHOLINE; CATECHOLAMINE; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; HYDROCORTISONE; MELATONIN; NORADRENALIN;

EID: 70350576241     PISSN: 1556407X     EISSN: 15564088     Source Type: Journal    
DOI: 10.1016/j.jsmc.2009.07.002     Document Type: Review
Times cited : (16)

References (64)
  • 1
    • 44949154024 scopus 로고    scopus 로고
    • Etiology and pathophysiology of insomnia
    • Kryger M., Roth T., and Dement W.C. (Eds), Elsevier Saunders, Philadelphia
    • Perlis M.L., Smith M.T., and Pigeon W.R. Etiology and pathophysiology of insomnia. In: Kryger M., Roth T., and Dement W.C. (Eds). Principle and practice of sleep medicine (2005), Elsevier Saunders, Philadelphia 714-725
    • (2005) Principle and practice of sleep medicine , pp. 714-725
    • Perlis, M.L.1    Smith, M.T.2    Pigeon, W.R.3
  • 3
    • 0000849795 scopus 로고
    • On the primacy of cognition
    • Lazarus R.S. On the primacy of cognition. Am Psychol 39 (1984) 124-129
    • (1984) Am Psychol , vol.39 , pp. 124-129
    • Lazarus, R.S.1
  • 4
    • 27644479900 scopus 로고    scopus 로고
    • Sleep is of the brain, by the brain and for the brain
    • Hobson J.A. Sleep is of the brain, by the brain and for the brain. Nature 437 (2005) 1254-1256
    • (2005) Nature , vol.437 , pp. 1254-1256
    • Hobson, J.A.1
  • 6
    • 27644457084 scopus 로고    scopus 로고
    • Hypothalamic regulation of sleep and circadian rhythms
    • Saper C.B., Scammell T.E., and Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 437 (2005) 1257-1263
    • (2005) Nature , vol.437 , pp. 1257-1263
    • Saper, C.B.1    Scammell, T.E.2    Lu, J.3
  • 7
    • 0036704933 scopus 로고    scopus 로고
    • Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update
    • Tekin S., and Cummings J.L. Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res 53 (2002) 647-654
    • (2002) J Psychosom Res , vol.53 , pp. 647-654
    • Tekin, S.1    Cummings, J.L.2
  • 8
    • 0018820658 scopus 로고
    • Insomniacs' perceptions of cognitive versus somatic determinants of sleep disturbance
    • Lichstein K.L., and Rosenthal T.L. Insomniacs' perceptions of cognitive versus somatic determinants of sleep disturbance. J Abnorm Psychol 89 (1980) 105-107
    • (1980) J Abnorm Psychol , vol.89 , pp. 105-107
    • Lichstein, K.L.1    Rosenthal, T.L.2
  • 9
    • 0020198082 scopus 로고
    • Physiological and psychological factors in sleep-onset insomnia
    • Freedman R.R., and Sattler H.L. Physiological and psychological factors in sleep-onset insomnia. J Abnorm Psychol 91 (1982) 380-389
    • (1982) J Abnorm Psychol , vol.91 , pp. 380-389
    • Freedman, R.R.1    Sattler, H.L.2
  • 10
    • 0021946331 scopus 로고
    • The phenomenology of the pre-sleep state: the development of the pre-sleep arousal scale
    • Nicassio P.M., Mendlowitz D.R., Fussell J.J., et al. The phenomenology of the pre-sleep state: the development of the pre-sleep arousal scale. Behav Res Ther 23 (1985) 263-271
    • (1985) Behav Res Ther , vol.23 , pp. 263-271
    • Nicassio, P.M.1    Mendlowitz, D.R.2    Fussell, J.J.3
  • 11
    • 0030756115 scopus 로고    scopus 로고
    • Insomnia in young men and subsequent depression. The Johns Hopkins Precursors Study
    • Chang P.P., Ford D.E., Mead L.A., et al. Insomnia in young men and subsequent depression. The Johns Hopkins Precursors Study. Am J Epidemiol 146 (1997) 105-114
    • (1997) Am J Epidemiol , vol.146 , pp. 105-114
    • Chang, P.P.1    Ford, D.E.2    Mead, L.A.3
  • 13
    • 0028101917 scopus 로고
    • Modulation of dorsal thalamic cell activity by the ventral pallidum: its role in the regulation of thalamocortical activity by the basal ganglia
    • Lavin A., and Grace A.A. Modulation of dorsal thalamic cell activity by the ventral pallidum: its role in the regulation of thalamocortical activity by the basal ganglia. Synapse 18 (1994) 104-127
    • (1994) Synapse , vol.18 , pp. 104-127
    • Lavin, A.1    Grace, A.A.2
  • 14
    • 0031915157 scopus 로고    scopus 로고
    • Dynamic properties of corticothalamic neurons and local cortical interneurons generating fast rhythmic (30-40 Hz) spike bursts
    • Steriade M., Timofeev I., Durmuller N., et al. Dynamic properties of corticothalamic neurons and local cortical interneurons generating fast rhythmic (30-40 Hz) spike bursts. J Neurophysiol 79 (1998) 483-490
    • (1998) J Neurophysiol , vol.79 , pp. 483-490
    • Steriade, M.1    Timofeev, I.2    Durmuller, N.3
  • 15
    • 84895302813 scopus 로고
    • Sleep as a problem of localization
    • Von Economo C. Sleep as a problem of localization. J Nerv Mental Dis 71 (1949) 249-259
    • (1949) J Nerv Mental Dis , vol.71 , pp. 249-259
    • Von Economo, C.1
  • 16
    • 70350588214 scopus 로고
    • Sleep mechanisms: summary statement
    • Moruzzi G. Sleep mechanisms: summary statement. Prog Brain Res 18 (1965) 241-243
    • (1965) Prog Brain Res , vol.18 , pp. 241-243
    • Moruzzi, G.1
  • 18
    • 0029268160 scopus 로고
    • Brain stem reticular formation and activation of the EEG. 1949
    • Moruzzi G., and Magoun H.W. Brain stem reticular formation and activation of the EEG. 1949. J Neuropsychiatr Clin Neurosci 7 (1995) 251-267
    • (1995) J Neuropsychiatr Clin Neurosci , vol.7 , pp. 251-267
    • Moruzzi, G.1    Magoun, H.W.2
  • 19
    • 0027490066 scopus 로고
    • The organization of central cholinergic systems and their functional importance in sleep-waking states
    • Jones B.E. The organization of central cholinergic systems and their functional importance in sleep-waking states. Prog Brain Res 98 (1993) 61-71
    • (1993) Prog Brain Res , vol.98 , pp. 61-71
    • Jones, B.E.1
  • 20
    • 84971139004 scopus 로고
    • Toward an understanding of the basic mechanisms of the sleep-waking cycle
    • Jones B.E. Toward an understanding of the basic mechanisms of the sleep-waking cycle. Behavior Brain Sci 1 (1978) 495
    • (1978) Behavior Brain Sci , vol.1 , pp. 495
    • Jones, B.E.1
  • 21
    • 0035576935 scopus 로고    scopus 로고
    • The sleep switch: hypothalamic control of sleep and wakefulness
    • Saper C.B., Chou T.C., and Scammell T.E. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 24 (2001) 726-731
    • (2001) Trends Neurosci , vol.24 , pp. 726-731
    • Saper, C.B.1    Chou, T.C.2    Scammell, T.E.3
  • 22
    • 0343851535 scopus 로고    scopus 로고
    • Hypocretin (orexin) pathway to sleep
    • George C.F., and Singh S.M. Hypocretin (orexin) pathway to sleep. Lancet 355 (2000) 6
    • (2000) Lancet , vol.355 , pp. 6
    • George, C.F.1    Singh, S.M.2
  • 23
    • 0034255401 scopus 로고    scopus 로고
    • The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders
    • Kilduff T.S., and Peyron C. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci 23 (2000) 359-365
    • (2000) Trends Neurosci , vol.23 , pp. 359-365
    • Kilduff, T.S.1    Peyron, C.2
  • 24
    • 0033588319 scopus 로고    scopus 로고
    • Narcolepsy: a key role for hypocretins (orexins)
    • Siegel J.M. Narcolepsy: a key role for hypocretins (orexins). Cell 98 (1999) 409-412
    • (1999) Cell , vol.98 , pp. 409-412
    • Siegel, J.M.1
  • 25
    • 0032842381 scopus 로고    scopus 로고
    • Narcolepsy genes wake up the sleep field
    • Takahashi J.S. Narcolepsy genes wake up the sleep field. Science 285 (1999) 2076-2077
    • (1999) Science , vol.285 , pp. 2076-2077
    • Takahashi, J.S.1
  • 26
    • 0033367369 scopus 로고    scopus 로고
    • Sleep homeostasis and models of sleep regulation
    • Borbely A.A., and Achermann P. Sleep homeostasis and models of sleep regulation. J Biol Rhythm 14 (1999) 557-568
    • (1999) J Biol Rhythm , vol.14 , pp. 557-568
    • Borbely, A.A.1    Achermann, P.2
  • 27
    • 2642679226 scopus 로고    scopus 로고
    • Processes underlying sleep regulation
    • Borbely A.A. Processes underlying sleep regulation. Horm Res 49 (1998) 114-117
    • (1998) Horm Res , vol.49 , pp. 114-117
    • Borbely, A.A.1
  • 28
    • 0001225830 scopus 로고    scopus 로고
    • Sleep homeostasis and models of sleep regulation
    • Kryger M., Roth T., and Dement W.C. (Eds), W.B. Saunders, Philadelphia
    • Borbely A.A., and Achermann P. Sleep homeostasis and models of sleep regulation. In: Kryger M., Roth T., and Dement W.C. (Eds). Principals and practice of sleep medicine. 3rd edition (2000), W.B. Saunders, Philadelphia 377-390
    • (2000) Principals and practice of sleep medicine. 3rd edition , pp. 377-390
    • Borbely, A.A.1    Achermann, P.2
  • 29
    • 0020368354 scopus 로고
    • A two process model of sleep regulation
    • Borbely A.A. A two process model of sleep regulation. Hum Neurobiol 1 (1982) 195-204
    • (1982) Hum Neurobiol , vol.1 , pp. 195-204
    • Borbely, A.A.1
  • 30
    • 33746285270 scopus 로고    scopus 로고
    • The attention-intention-effort pathway in the development of psychophysiologic insomnia: an invited theoretical review
    • Espie C.A., Broomfield N.M., MacMahon K.M.A., et al. The attention-intention-effort pathway in the development of psychophysiologic insomnia: an invited theoretical review. Sleep Med Rev 10 (2006) 215-245
    • (2006) Sleep Med Rev , vol.10 , pp. 215-245
    • Espie, C.A.1    Broomfield, N.M.2    MacMahon, K.M.A.3
  • 31
    • 0030756732 scopus 로고    scopus 로고
    • Psychophysiological insomnia: the behavioural model and a neurocognitive perspective
    • Perlis M.L., Giles D.E., Mendelson W.B., et al. Psychophysiological insomnia: the behavioural model and a neurocognitive perspective. J Sleep Res 6 (1997) 179-188
    • (1997) J Sleep Res , vol.6 , pp. 179-188
    • Perlis, M.L.1    Giles, D.E.2    Mendelson, W.B.3
  • 33
    • 0026675375 scopus 로고
    • The EEG of the sleep onset period in insomnia: a discriminant analysis
    • Merica H., and Gaillard J.M. The EEG of the sleep onset period in insomnia: a discriminant analysis. Physiol Behav 52 (1992) 199-204
    • (1992) Physiol Behav , vol.52 , pp. 199-204
    • Merica, H.1    Gaillard, J.M.2
  • 34
    • 0031815760 scopus 로고    scopus 로고
    • Spectral characteristics of sleep EEG in chronic insomnia
    • Merica H., Blois R., and Gaillard J.M. Spectral characteristics of sleep EEG in chronic insomnia. Eur J Neurosci 10 (1998) 1826-1834
    • (1998) Eur J Neurosci , vol.10 , pp. 1826-1834
    • Merica, H.1    Blois, R.2    Gaillard, J.M.3
  • 35
    • 0030712970 scopus 로고    scopus 로고
    • Electrophysiological changes during the sleep onset period of psychophysiological insomniacs, psychiatric insomniacs, and normal sleepers
    • Lamarche C.H., and Ogilvie R.D. Electrophysiological changes during the sleep onset period of psychophysiological insomniacs, psychiatric insomniacs, and normal sleepers. Sleep 20 (1997) 724-733
    • (1997) Sleep , vol.20 , pp. 724-733
    • Lamarche, C.H.1    Ogilvie, R.D.2
  • 36
    • 0027819715 scopus 로고
    • Home-based central nervous system assessment of a multifactor behavioral intervention for chronic sleep-onset insomnia
    • Jacobs G.D., Benson H., and Friedman R. Home-based central nervous system assessment of a multifactor behavioral intervention for chronic sleep-onset insomnia. Behavior Ther 24 (1993) 159-174
    • (1993) Behavior Ther , vol.24 , pp. 159-174
    • Jacobs, G.D.1    Benson, H.2    Friedman, R.3
  • 37
    • 0035253295 scopus 로고    scopus 로고
    • Beta/gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls
    • Perlis M.L., Smith M.T., Orff H.J., et al. Beta/gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls. Sleep 24 (2001) 110-117
    • (2001) Sleep , vol.24 , pp. 110-117
    • Perlis, M.L.1    Smith, M.T.2    Orff, H.J.3
  • 38
    • 0037105029 scopus 로고    scopus 로고
    • NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes
    • Krystal A.D., Edinger J.D., Wohlgemuth W.K., et al. NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep 25 (2002) 630-640
    • (2002) Sleep , vol.25 , pp. 630-640
    • Krystal, A.D.1    Edinger, J.D.2    Wohlgemuth, W.K.3
  • 39
    • 0034071448 scopus 로고    scopus 로고
    • Symptoms of stress and depression as correlates of sleep in primary insomnia
    • Hall M., Buysse D.J., Nowell P.D., et al. Symptoms of stress and depression as correlates of sleep in primary insomnia. Psychosom Med 62 (2000) 227-230
    • (2000) Psychosom Med , vol.62 , pp. 227-230
    • Hall, M.1    Buysse, D.J.2    Nowell, P.D.3
  • 40
    • 0034630170 scopus 로고    scopus 로고
    • Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep
    • Nofzinger E.A., Price J.C., Meltzer C.C., et al. Towards a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep. Psychiatr Res 98 (2000) 71-91
    • (2000) Psychiatr Res , vol.98 , pp. 71-91
    • Nofzinger, E.A.1    Price, J.C.2    Meltzer, C.C.3
  • 41
    • 0041851051 scopus 로고    scopus 로고
    • Sleep EEG power spectra, insomnia, and chronic use of benzodiazepines
    • Bastien C.H., LeBlanc M., Carrier J., et al. Sleep EEG power spectra, insomnia, and chronic use of benzodiazepines. Sleep 26 (2003) 313-317
    • (2003) Sleep , vol.26 , pp. 313-317
    • Bastien, C.H.1    LeBlanc, M.2    Carrier, J.3
  • 42
    • 1842559910 scopus 로고    scopus 로고
    • Paradoxes of the first-night effect: a quantitative analysis of antero-posterior EEG topography
    • Curcio G., Ferrara M., Piergianni A., et al. Paradoxes of the first-night effect: a quantitative analysis of antero-posterior EEG topography. Clin Neurophysiol 115 (2004) 1178-1188
    • (2004) Clin Neurophysiol , vol.115 , pp. 1178-1188
    • Curcio, G.1    Ferrara, M.2    Piergianni, A.3
  • 43
    • 57349180396 scopus 로고    scopus 로고
    • EEG spectral analysis in primary insomnia: NREM period effects and sex differences
    • Buysse D.J., Germain A., Hall M.L., et al. EEG spectral analysis in primary insomnia: NREM period effects and sex differences. Sleep 31 (2008) 1673-1682
    • (2008) Sleep , vol.31 , pp. 1673-1682
    • Buysse, D.J.1    Germain, A.2    Hall, M.L.3
  • 44
    • 0015148519 scopus 로고
    • Relationship between sleep habits, adrenocortical activity and personality
    • Johns M.W. Relationship between sleep habits, adrenocortical activity and personality. Psychosom Med 33 (1971) 499-508
    • (1971) Psychosom Med , vol.33 , pp. 499-508
    • Johns, M.W.1
  • 45
    • 0032126072 scopus 로고    scopus 로고
    • Chronic insomnia and activity of the stress system: a preliminary study
    • Vgontzas A.N., Tsigos C., Bixler E.O., et al. Chronic insomnia and activity of the stress system: a preliminary study. J Psychosom Res 45 (1998) 21-31
    • (1998) J Psychosom Res , vol.45 , pp. 21-31
    • Vgontzas, A.N.1    Tsigos, C.2    Bixler, E.O.3
  • 46
    • 0034891350 scopus 로고    scopus 로고
    • Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
    • Vgontzas A.N., Bixler E.O., Lin H.M., et al. Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J Clin Endocrinol Metab 86 (2001) 3787-3794
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3787-3794
    • Vgontzas, A.N.1    Bixler, E.O.2    Lin, H.M.3
  • 47
    • 0037114797 scopus 로고    scopus 로고
    • Nocturnal cortisol and melatonin secretion in primary insomnia
    • Riemann D., Klein T., Rodenbeck A., et al. Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiatr Res 113 (2002) 17-27
    • (2002) Psychiatr Res , vol.113 , pp. 17-27
    • Riemann, D.1    Klein, T.2    Rodenbeck, A.3
  • 49
    • 54049096751 scopus 로고    scopus 로고
    • Neural circuitry of stress-induced insomnia in rats
    • Cano G., Mochizuki T., and Saper C.B. Neural circuitry of stress-induced insomnia in rats. J Neurosci 28 (2008) 10167-10184
    • (2008) J Neurosci , vol.28 , pp. 10167-10184
    • Cano, G.1    Mochizuki, T.2    Saper, C.B.3
  • 50
    • 0024448838 scopus 로고
    • Epidemiologic study of sleep disturbances and psychiatric disorders: an opportunity for prevention?
    • [see comments]
    • Ford D.E., and Kamerow D.B. Epidemiologic study of sleep disturbances and psychiatric disorders: an opportunity for prevention?. JAMA 262 (1989) 1479-1484 [see comments]
    • (1989) JAMA , vol.262 , pp. 1479-1484
    • Ford, D.E.1    Kamerow, D.B.2
  • 51
    • 0025883522 scopus 로고
    • Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program
    • Dryman A., and Eaton W.W. Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program. Acta Psychiatr Scand 84 (1991) 1-5
    • (1991) Acta Psychiatr Scand , vol.84 , pp. 1-5
    • Dryman, A.1    Eaton, W.W.2
  • 52
    • 0029866450 scopus 로고    scopus 로고
    • Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults
    • Breslau N., Roth T., Rosenthal L., et al. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatr 39 (1996) 411-418
    • (1996) Biol Psychiatr , vol.39 , pp. 411-418
    • Breslau, N.1    Roth, T.2    Rosenthal, L.3
  • 53
    • 0027452453 scopus 로고
    • Does sleep disturbance predict depression in elderly people? A study in inner London
    • [see comments]
    • Livingston G., Blizard B., and Mann A. Does sleep disturbance predict depression in elderly people? A study in inner London. Br J Gen Pract 43 (1993) 445-448 [see comments]
    • (1993) Br J Gen Pract , vol.43 , pp. 445-448
    • Livingston, G.1    Blizard, B.2    Mann, A.3
  • 54
    • 0033783897 scopus 로고    scopus 로고
    • Relationship between insomnia, depression, and mortality: a 12-year follow-up of older adults in the community
    • Mallon L., Broman J.E., and Hetta J. Relationship between insomnia, depression, and mortality: a 12-year follow-up of older adults in the community. Int Psychogeriatr 12 (2000) 295-306
    • (2000) Int Psychogeriatr , vol.12 , pp. 295-306
    • Mallon, L.1    Broman, J.E.2    Hetta, J.3
  • 55
    • 0033959413 scopus 로고    scopus 로고
    • Sleep complaints and depression in an aging cohort: a prospective perspective
    • [In Process Citation]
    • Roberts R.E., Shema S.J., Kaplan G.A., et al. Sleep complaints and depression in an aging cohort: a prospective perspective. [In Process Citation]. Am J Psychiatr 157 (2000) 81-88
    • (2000) Am J Psychiatr , vol.157 , pp. 81-88
    • Roberts, R.E.1    Shema, S.J.2    Kaplan, G.A.3
  • 56
    • 0024439983 scopus 로고
    • The Zurich study. VIII. Insomnia: association with depression, anxiety, somatic syndromes, and course of insomnia
    • Vollrath M., Wicki W., and Angst J. The Zurich study. VIII. Insomnia: association with depression, anxiety, somatic syndromes, and course of insomnia. Eur Arch Psychiatry Neurol Sci 239 (1989) 113-124
    • (1989) Eur Arch Psychiatry Neurol Sci , vol.239 , pp. 113-124
    • Vollrath, M.1    Wicki, W.2    Angst, J.3
  • 57
    • 0030806104 scopus 로고    scopus 로고
    • The morbidity of insomnia uncomplicated by psychiatric disorders
    • Weissman M.M., Greenwald S., Nino-Murcia G., et al. The morbidity of insomnia uncomplicated by psychiatric disorders. Gen Hosp Psychiatr 19 (1997) 245-250
    • (1997) Gen Hosp Psychiatr , vol.19 , pp. 245-250
    • Weissman, M.M.1    Greenwald, S.2    Nino-Murcia, G.3
  • 58
    • 0343307014 scopus 로고    scopus 로고
    • Self-reported sleep disturbance as a prodromal symptom in recurrent depression
    • Perlis M.L., Giles D.E., Buysse D.J., et al. Self-reported sleep disturbance as a prodromal symptom in recurrent depression. J Affect Disord 42 (1997) 209-212
    • (1997) J Affect Disord , vol.42 , pp. 209-212
    • Perlis, M.L.1    Giles, D.E.2    Buysse, D.J.3
  • 59
    • 0343376113 scopus 로고    scopus 로고
    • Which depressive symptoms are related to which sleep electroencephalographic variables?
    • Perlis M.L., Giles D.E., Buysse D.J., et al. Which depressive symptoms are related to which sleep electroencephalographic variables?. Biol Psychiatr 42 (1997) 904-913
    • (1997) Biol Psychiatr , vol.42 , pp. 904-913
    • Perlis, M.L.1    Giles, D.E.2    Buysse, D.J.3
  • 60
    • 0032822490 scopus 로고    scopus 로고
    • Antidepressant treatment of the depressed patient with insomnia
    • Thase M.E. Antidepressant treatment of the depressed patient with insomnia. J Clin Psychiatr 60 Suppl 17 (1999) 28-31
    • (1999) J Clin Psychiatr , vol.60 , Issue.SUPPL. 17 , pp. 28-31
    • Thase, M.E.1
  • 61
    • 0036570595 scopus 로고    scopus 로고
    • Neuroimaging of NREM sleep in primary insomnia: a Tc-99-HMPAO single photon emission computed tomography study
    • Smith M.T., Perlis M.L., Chengazi V.U., et al. Neuroimaging of NREM sleep in primary insomnia: a Tc-99-HMPAO single photon emission computed tomography study. Sleep 25 (2002) 325-335
    • (2002) Sleep , vol.25 , pp. 325-335
    • Smith, M.T.1    Perlis, M.L.2    Chengazi, V.U.3
  • 62
    • 7444227411 scopus 로고    scopus 로고
    • Insomnia: functional imaging evidence for hyperarousal
    • Nofzinger E.A., Buysee D.J., Germain A., et al. Insomnia: functional imaging evidence for hyperarousal. Am J Psychiatr 161 (2004) 2126-2128
    • (2004) Am J Psychiatr , vol.161 , pp. 2126-2128
    • Nofzinger, E.A.1    Buysee, D.J.2    Germain, A.3
  • 63
    • 55549147201 scopus 로고    scopus 로고
    • Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS)
    • Winkelman J.W., Buxton O.M., Jensen J.E., et al. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep 31 (2008) 1499-1506
    • (2008) Sleep , vol.31 , pp. 1499-1506
    • Winkelman, J.W.1    Buxton, O.M.2    Jensen, J.E.3
  • 64
    • 2642563606 scopus 로고    scopus 로고
    • Functional imaging of the sleeping brain: review of findings and implications for the study of insomnia
    • Drummond S.P., Smith M.T., Orff H.J., et al. Functional imaging of the sleeping brain: review of findings and implications for the study of insomnia. Sleep Med Rev 8 (2004) 227-242
    • (2004) Sleep Med Rev , vol.8 , pp. 227-242
    • Drummond, S.P.1    Smith, M.T.2    Orff, H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.