In vitro prevention of vaccinia and herpesvirus infection spread in explanted human corneas by N-chlorotaurine

Ophthalmic Research

Volumn 43, Issue 3, 2010, Pages 145-152

  Huemer, Hartwig P ^a   Nagl, Markus ^a   Irschick, Eveline U ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Cornea; Herpesvirus; Keratitis; N chlorotaurine; Oxidation; Poxvirus; Taurine chloramine

Indexed keywords

N CHLOROTAURINE; TAURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; CORNEA TRANSPLANTATION; CULTURE MEDIUM; CYTOPATHOGENIC EFFECT; HERPES VIRUS; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFECTION CONTROL; INFECTION PREVENTION; NONHUMAN; POXVIRUS; PRIORITY JOURNAL; SUSPENSION; VACCINIA; VACCINIA VIRUS;

ANTIVIRAL AGENTS; CORNEA; CYTOPATHOGENIC EFFECT, VIRAL; HERPESVIRUS 1, HUMAN; HUMANS; ORGAN CULTURE TECHNIQUES; TAURINE; VACCINIA VIRUS; VIRULENCE;

EID: 70350560455     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000253846     Document Type: Article

References (33)

1. Marquez LA, Dunford HB: Chlorination of taurine by myeloperoxidase. Kinetic evidence for an enzyme-bound intermediate. J Biol Chem 1994; 269: 7950-7956.
2. Lin YY, Wright CE, Zagorski M, Nakanishi K: 13 C-NMR study of taurine and chlorotaurine in human cells. Biochim Biophys Acta 1988; 969: 242-248.
3. Weiss SJ, Klein R, Slivka A, Wei M: Chlorination of taurine by human neutrophils. J Clin Investig 1982; 70: 598-607.
4. Thomas EL: Myeloperoxidase, hydrogen peroxide, chloride antimicrobial system: effect of exogenous amines on the antibacterial action against Escherichia coli. Infect Immun 1979; 25: 110-116.
5. Yazdanbakhsh M, Eckmann CM, Roos D: Killing of schistosomula by taurine chloramine and taurine bromamine. Am J Trop Med Hyg 1987; 37: 106-110.
6. Nagl M, Gottardi W: Enhancement of the bactericidal efficacy of N-chlorotaurine by inflammation samples and selected N-H compounds. Hyg Med 1996; 21: 597-605.
7. Nagl M, Lass-Floerl C, Neher A, Gunkel AR, Gottardi W: Enhanced fungicidal activity of N-chlorotaurine in nasal secretion. J Antimicrob Chemother 2001; 47: 871-874.
8. Marcinkiewicz J, Biedron R, Bialecka A, Kasprowicz A, Mak M, Targosz M: Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris. Arch Immunol Ther Exp (Warsz) 2006; 54: 61-68.
9. Fürnkranz U, Nagl M, Gottardi W, Köhsler M, Aspöck H, Walochnik J: Cytotoxic activities of N-chlorotaurine (NCT) on Acanthamoeba spp. Antimicrob Agents Chemother 2008; 52: 470-476.
10. Benov L, Fridovich I: Escherichia coli exhibits negative chemotaxis in gradients of hydrogen peroxide, hypochlorite, and N-chlorotaurine: products of the respiratory burst of phagocytic cells. Proc Natl Acad Sci USA 1996; 93: 4999-5002.
11. Carr AC, Hawkins CL, Thomas SR, Stocker R, Frei B: Relative reactivities of N-chloramines and hypochlorous acid with human plasma constituents. Free Radic Biol Med 2001; 30: 526-536.
12. Gottardi W, Nagl M: Chemical properties of N-chlorotaurine sodium, a key compound in the human defence system. Arch Pharm Pharm Med Chem 2002; 335: 411-421.
13. Peskin AV, Winterbourn CC: Taurine chloramine is more selective than hypochlorous acid at targeting critical cysteines and inactivating creatine kinase and glyceraldehyde- 3-phosphate dehydrogenase. Free Radic Biol Med 2006; 40: 45-53.
14. Grisham MB, Jefferson MM, Thomas EL: Role of monochloramine in the oxidation of erythrocyte hemoglobin by stimulated neutrophils. J Biol Chem 1984; 259: 6757-6765.
15. Tatsumi T, Fliss H: Hypochlorous acid and chloramines increase endothelial permeability: possible involvement of cellular zinc. Am J Physiol 1994; 267: 1597-1607.
16. Marcinkiewicz J, Kurnyta M, Biedron R, Bobek M, Kontny E, Maslinski W: Anti-inflammatory effects of taurine derivatives (taurine chloramine, taurine bromamine, and taurolidine) are mediated by different mechanisms. Adv Exp Med Biol 2006; 583: 481-492.
17. Schuller-Levis GB, Park E: Taurine and its chloramine: modulators of immunity. Neurochem Res 2004; 29: 117-126.
18. Marcinkiewicz J, Nowak B, Grabowska A, Bobek M, Petrovska L, Chain B: Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase-halide system. Immunology 1999; 98: 371-378.
19. Park E, Jia J, Quinn MR, Schuller-Levis G: Taurine chloramine inhibits lymphocyte proliferation and decreases cytokine production in activated human leukocytes. Clin Immunol 2002; 102: 179-184.
20. Nagl M, Larcher C, Gottardi W: Activity of N-chlorotaurine against herpes simplexand adenoviruses. Antiviral Res 1998; 38: 25-30.
21. Romanowski EG, Yates KA, Teuchner B, Nagl M, Irschick EU, Gordon YJ: N-chlorotaurine is an effective antiviral agent against adenovirus in vitro and in the Ad5/NZW rabbit ocular model. Invest Ophthalmol Vis Sci 2006; 47: 2021-2026.
22. Dudani AK, Martyres A, Fliss H: Short communication: rapid preparation of preventive and therapeutic whole-killed retroviral vaccines using the microbicide taurine chloramine. AIDS Res Hum Retroviruses 2008; 24: 635-642.
23. Teuchner B, Nagl M, Schidlbauer A, Ishiko H, Dragosits E, Ulmer H, Aoki K, Ohno S, Mizuki N, Gottardi W, Larcher C: Tolerability and efficacy of N-chlorotaurine in epidemic keratoconjunctivitis - a double-blind randomized phase 2 clinical trial. J Ocular Pharmacol Ther 2005; 21: 157-165.
24. Dolezalová V: Blindness due to variola in the young Wolfgang Amadeus Mozart (in Czech). Cesk Slov Oftalmol 2001; 57: 284-286.
25. Semba RD: The ocular complications of smallpox and smallpox immunization. Arch Ophthalmol 2003; 121: 715-719.
26. Huemer HP, Larcher C, Kirchebner W, Klingenschmid J, Gottinger W, Irschick EU: Susceptibility of human retinal pigment epithelial cells to different viruses. Graefes Arch Clin Exp Ophthalmol 1996; 234: 177-185.
27. Lennette EH, Schmidt NJ: Diagnostic procedures for viral, rickettsial and chlamydial infection, ed 5. Washington, American Public Health Association, 1979.
28. Janeczko RA, Rodriguez JF, Esteban M: Studies on the mechanism of entry of vaccinia virus in animal cells. Arch Virol 1987; 92: 135-150.
29. Huemer HP, Bröker M, Larcher C, Lambris JD, Dierich MP: The central segment of herpes simplex virus type 1 glycoprotein C (gC) is not involved in C3b binding: demonstration by using monoclonal antibodies and recombinant gC expressed in Escherichia coli. J Gen Virol 1989; 70: 1571-1578.
30. Koller W, Rotter ML, Gottardi W: Do 'chlorine covers' exert a sustained bactericidal effect on the bacterial hand flora? J Hosp Infect 1995; 31: 169-176.
31. Peskin AV, Midwinter RG, Harwood DT, Winterbourn CC: Chlorine transfer between glycine, taurine, and histamine: reaction rates and impact on cellular reactivity. Free Radic Biol Med 2004; 37: 1622-1630.
32. Teuchner B, Schmid E, Ulmer H, Gottardi W, Nagl M: Tolerability of N-chlorotaurine plus ammonium chloride in the rabbit and human eye - a phase 1 clinical study. Graefes Arch Clin Exp Ophthalmol 2008; 246: 1723-1730.
33. Foster A, Johnson GJ: Measles, corneal ulceration and childhood blindness: prevention and treatment. Trop Doct 1988; 18: 74-78.