Microbial quorum sensing: A tool or a target for antimicrobial therapy?

Biotechnology and Applied Biochemistry

Volumn 54, Issue 2, 2009, Pages 65-84

  Raina, Sheetal ^a   De Vizio, Daniela ^a   Odell, Mark ^a   Clements, Mark ^a   Vanhulle, Sophie ^b   Keshavarz, Tajalli ^a  

^a UNIVERSITY OF WESTMINSTER   (United Kingdom)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Acylhomoserine lactone (AHL); Autoinducer; Butyrolactones; Furanones; Quorum sensing; Signal transduction

Indexed keywords

ACYLHOMOSERINE LACTONE (AHL); AUTOINDUCER; BUTYROLACTONES; FURANONES; QUORUM SENSING;

AMINES; BACTERIOLOGY; BACTERIOPHAGES; CELL MEMBRANES; COMPETITION; SENSORS; SIGNAL TRANSDUCTION;

BACTERIA;

BACTERIAL PROTEIN; BACTERIOCIN; CARBAPENEM; EXOPOLYSACCHARIDE; FACTOR A; FURANONE DERIVATIVE; N ACYLHOMOSERINE LACTONE; NATAMYCIN; NISIN; PHENAZINE; PROTEIN COMC; PROTEIN COMX; PROTEIN LASL; PROTEIN LASR; PROTEIN RHL; PROTEIN SCBI; S RIBOSYLHOMOCYSTEINASE; TRANSCRIPTION FACTOR LUXR; TYLOSIN; UNCLASSIFIED DRUG;

BACTERIAL VIRULENCE; CELL COMMUNICATION; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METABOLITE; NONHUMAN; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; REVIEW; RHIZOBIUM RADIOBACTER; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTI-INFECTIVE AGENTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HOMOSERINE; LACTONES; MODELS, BIOLOGICAL; QUORUM SENSING;

FUNGI; NEGIBACTERIA; POSIBACTERIA;

EID: 70350550086     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20090072     Document Type: Review

References (212)

1. Fuqua, W. C., Winans, S. C. and Greenberg, E. P. (1994) J. Bacteriol. 176, 269-275
2. Nealson, K. H., Platt, T. and Hastings, J.W. (1970) J. Bacteriol. 104, 313-322
3. Greenberg, E. P. (2003) J. Clin. Invest. 112, 1288-1290
4. Surette, M. G. and Bassler, B. L. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 7046-7050
5. Swift, S., Downie, J. A., Whitehead, N. A., Barnard, A. M. L., Salmond, G. P. C. and Williams, P. (2001) Adv. Microb. Physiol. 45, 199-270
6. Eberhard, A., Burlingame, A. L., Eberhard, C., Kenyon, G. L., Nealson, K. H. and Oppenheimer, N. J. (1981) Biochemistry. 20, 2444-2449
7. Engebrecht, J., Nealson, K. and Silverman, M. (1983) Cell 32, 773-781
8. Withers, H., Swift, S. and Williams, P. (2001) Curr. Opin. Microbiol. 4, 186-193
9. Miller, M. B. and Bassler, B. L. (2001) Annu. Rev. Microbiol. 55, 165-199
10. Bassler, B. L. (1999) Curr. Opin. Microbiol. 2, 582-587
11. Kleerebezem, M., Quadri, L. E., Kuipers, O. P. and de Vos, W. M. (1997) Mol. Microbiol. 24, 895-904
12. Bassler, B. L. (2002) Cell 109, 421-424
13. Parkinson, J. (1995) in Two-Component Signal Transduction (Hoch, J. and Silhavy, T., eds), pp. 9-23, ASM Press, Washington
14. Dunny, G. M. and Leonard, B. A. B. (1997) Annu. Rev. Microbiol. 51, 527-564
15. Miller, V. L. and Mekalanos, J. J. (1988) J. Bacteriol. 170, 2575-2583
16. Gambello, M. J. and Iglewski, B. H. (1991) J. Bacteriol. 173, 3000-3009
17. Throup, J. P., Camara, M., Briggs, G. S., Winson, M. K., Chhabra, S. R., Bycroft, B.W., Williams, P. and Stewart, G. S. (1995) Mol. Microbiol. 17, 345-356
18. Pesci, E. C., Pearson, J. P., Seed, P. C. and Iglewski, B. H. (1997) J. Bacteriol. 179, 3127-3132
19. Lewenza, S., Conway, B., Greenberg, E. P. and Sokol, P. A. (1999) J. Bacteriol. 181, 748-756
20. Passador, L., Cook, J. M., Gambello, M. J., Rust, L. and Iglewski, B. H. (1993) Science 260, 1127-1130
21. Winson, M. K., Camara, M., Latifi, A., Foglino, M., Chhabra, S. R., Daykin, M., Bally, M., Chapon, V., Salmond, G. P., Bycroft, B. W. et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 9427-9431
22. Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W. and Greenberg, E. P. (1998) Science 280, 295-298
23. Yoon, S. S., Hennigan, R. F., Hilliard, G. M., Ochsner, U. A., Parvatiyar, K., Kamani, M. C., Allen, H. L., DeKievit, T. R., Gardner, P. R., Schwab, U. et al. (2002) Dev. Cell 3, 593-603
24. Hentzer, M., Eberl, L., Nielsen, J. and Givskov, M. (2003) BioDrugs 17, 241-250
25. Wagner, V. E., Bushnell, D., Passador, L., Brooks, A. I. and Iglewski, B. H. (2003) J. Bacteriol. 185, 2080-2095
26. Schuster, M., Lostroh, C. P., Ogi, T. and Greenberg, E. P. (2003) J. Bacteriol. 185, 2066-2079
27. Whiteley, M., Lee, K. M. and Greenberg, E. P. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 13904-13909
28. Hentzer, M., Givskov, M. and Eberl, L. (2004) in Microbial Biofilms (O'Toole, G. A., ed.), pp. 118-140, ASM Press, Washington
29. Gambello, M. J., Kaye, S. and Iglewski, B. H. (1993) Infect. Immun. 61, 1180-1184
30. Pearson, J. P., Gray, K. M., Passador, L., Tucker, K. D., Eberhard, A., Iglewski, B. H. and Greenberg, E. P. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 197-201
31. Latifi, A., Foglino, M., Tanaka, K., Williams, P. and Lazdunski, A. (1996) Mol. Microbiol. 21, 1137-1146
32. Ochsner, U. A., Fiechter, A. and Reiser, J. (1994) J. Biol. Chem. 269, 19787-19795
33. Ochsner, U. A. and Reiser, J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 6424-6428
34. Pearson, J. P., Passador, L., Iglewski, B. H. and Greenberg, E. P. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1490-1494
35. Ochsner, U. A., Koch, A. K., Fiechter, A. and Reiser, J. (1994) J. Bacteriol. 176, 2044-2054
36. Cabrol, S., Olliver, A., Pier, G. B., Andremont, A. and Ruimy, R. (2003) J. Bacteriol. 185, 7222-72230
37. Smith, E. E., Buckley, D. G., Wu, Z., Saenphimmachak, C., Hoffman, L. R., D'Argenio, D. A., Miller, S. I., Ramsey, B. W., Speert, D. P., Moskowitz, S. M. et al. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 8487-8492
38. Duan, K. and Surette, M. G. (2007) J. Bacteriol. 189, 4827-4836
39. Venturi, V. (2006) FEMS Microbiol. Rev. 30, 274-291
40. Tang, H. B., DiMango, E., Bryan, R., Gambello, M., Iglewski, B. H., Goldberg, J. B. and Prince, A. (1996) Infect. Immun. 64, 37-43
41. Rumbaugh, K. P., Griswold, J. A., Iglewski, B. H. and Hamood, A. N. (1999) Infect. Immun. 67, 5854-5862
42. Wu, H., Song, Z., Hentzer, M., Andersen, J. B., Heydorn, A., Mathee, K., Moser, C., Eberl, L., Molin, S., Hoiby, N. and Givskov, M. (2000) Microbiology 146, 2481-2493
43. Tan, M.-W., Mahajan-Miklos, S. and Ausubel, F. M. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 715-720
44. Rumbaugh, K. P., Diggle, S. P., Watters, C. M., Ross-Gillespie, A., Griffin, A. S. and West, S. A. (2009) Curr. Biol. 19, 341-345
45. Chugani, S. A., Whiteley, M., Lee, K. M., D'Argenio, D., Manoil, C. and Greenberg, E. P. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 2752-2757
46. Ledgham, F., Ventre, I., Soscia, C., Foglino, M., Sturgis, J. N. and Lazdunski, A. (2003) Mol. Microbiol. 48, 199-210
47. Juhas, M., Wiehlmann, L., Huber, B., Jordan, D., Lauber, J., Salunkhe, P., Limpert, A. S., von Gotz, F., Steinmetz, I., Eberl, L. and Tummler, B. (2004) Microbiology 150, 831-841
48. Diggle, S. P., Winzer, K., Chhabra, S. R., Worrall, K. E., Camara, M. and Williams, P. (2003) Mol. Microbiol. 50, 29-43
49. Pesci, E. C., Milbank, J. B., Pearson, J. P., McKnight, S., Kende, A. S., Greenberg, E. P. and Iglewski, B. H. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 11229-11234
50. Smith, R. S. and Iglewski, B. H. (2003) J. Clin. Invest. 112, 1460-1465
51. Tateda, K., Ishii, Y. and Yamaguchi, K. (2004) Nippon Saikingaku Zasshi 59, 543-549
52. Giacometti, A., Cirioni, O., Gov, Y., Ghiselli, R., Del Prete, M. S., Mocchegiani, F., Saba, V., Orlando, F., Scalise, G., Balaban, N. and Dell'Acqua, G. (2003) Antimicrob. Agents Chemother. 47, 1979-1983
53. Lowry, F. D. (1998) N. Engl. J. Med. 339, 520-532
54. Mehlin, C., Headley, C. M. and Klebanoff, S. J. (1999) J. Exp. Med. 189, 907-918
55. Balaban, N. and Novick, R. P. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1619-1623
56. Morfeldt, E. D., Taylor, A., Gabain, V. and Arvidson, S. (1995) EMBO J. 14, 4569-4457
57. Novick, R. P., Projan, S. J., Kornblum, J., Ross, H. F., Ji, G., Kreiswirth, B., Vandenesch, F. and Moghazeh, S. (1995) Mol. Gen. Genet. 248, 446-458
58. Ji, G., Beavis, R. C. and Novick, R. P. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 12055-12059
59. Mayville, P., Ji, G., Beavis, R., Yang, H., Goger, M., Novick, R. P. and Muir, T. W. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1218-1223
60. Otto, M., Süssmuth, R., Jung, G. and Götz, F. (1998) FEBS Lett. 424, 89-94
61. Saenz, H. L., Augsburger, V., Vuong, C., Jack, R. W., Götz, F. and Otto, M. (2000) Arch. Microbiol. 174, 452-455
62. Zhang, L., Lin, J. and Ji, G. (2004) J. Biol. Chem. 279, 19448-19456
63. Otto, M., Süssmuth, R., Vuong, C., Jung, G. and Götz, F. (1999) FEBS Lett. 450, 257-262
64. Koenig, R. L., Ray, J. L., Maleki, S. J., Smeltzer, M. S. and Hurlburt, B. K. (2004) J. Bacteriol. 186, 7549-7555
65. Huntzinger, E., Boisset, S., Saveanu, C., Benito, Y., Geissmann, T., Namane, A., Lina, G., Etienne, J., Ehresmann, B., Ehresmann, J. A. et al. (2005) EMBO J. 24, 824-835
66. Novick, R. P. and Geisinger, E. (2008) Annu. Rev. Genet. 42, 541-564
67. Novick, R. P. (2003) Mol. Microbiol. 48, 1429-1449
68. Otto, M. (2004) FEMS Microbiol. Lett. 241, 135-141
69. Vuong, C., Dürr, M., Carmody, A. B., Peschel, A., Klebanoff, S. J. and Otto, M. (2004) Cell. Microbiol. 6, 753-759
70. Yang, G., Cheng, H., Liu, C., Xue, Y., Gao, Y., Liu, N., Gao, B., Wang, D., Li, S., Shen, B. and Shao, N. (2003) Peptides 24, 1823-1828
71. Yarwood, J. M., Bartels, D. J., Volper, E. M. and Greenberg, E. P. (2004) J. Bacteriol. 186, 1838-1850
72. Klapwijk, P. M., Scheulderman, T. and Schilperoort, R. A. (1978) J. Bacteriol. 136, 775-785
73. Ellis, J. G., Kerr, A., Petit, A. and Tempe, J. (1982) Mol. Gen. Genet. 186, 269-274
74. Habeeb, L. F., Wang, L. and Winans, S. C. (1991) Mol. Plant-Microbe Interact. 4, 379-385
75. Wang, L., Helmann, J. D. and Winans, S. C. (1992) Cell 69, 659-667
76. Fuqua, C. and Winans, S. C. (1996) Mol. Microbiol. 20, 1199-1210
77. Piper, K. R., Beck von Bodman, S., Hwang, I. and Farrand, S. K. (1999) Mol. Microbiol. 32, 1077-1089
78. More, M. I., Finger, L. D., Stryker, J. L., Fuqua, C., Eberhard, A. and Winans, S. C. (1996) Science 272, 1655-1658
79. Von Bodman, S. B., Hayman, G. T. and Farrand, S. K. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 643-647
80. Kim, H. and Farrand, S. K. (1997) J. Bacteriol. 179, 7559-7572
81. Fuqua, C., Burbea, M. and Winans, S. C. (1995) J. Bacteriol. 177, 1367-1373
82. Hwang, I., Cook, D. M. and Farrand, S. K. (1995) J. Bacteriol. 177, 449-458
83. Hwang, I., Smyth, A. J., Luo, Z. Q. and Farrand, S. K. (1999) Mol. Microbiol. 34, 282-294
84. Luo, Z.-Q., Qin, Y. and Farrand, S. K. (2000) J. Biol. Chem. 275, 7713-7722
85. Piper, K. R. and Farrand, S. K. (2000) J. Bacteriol. 182, 1080-1088
86. Perombelon, M. C. M. and Kelman, A. (1980) Annu. Rev. Phytopathol. 18, 361-387
87. Demain, A. L. (1998) Int. Microbiol. 1, 259-264
88. Quadri, L. E. N. (2002) Antonie van Leeuwenhoek 82, 133-145
89. Vandenbergh, V. A. (1993) FEMS Microbiol. Rev. 12, 221-237
90. Buchman, G. W., Banerjee, S. and Hansen, J. N. (1988) J. Biol. Chem. 263, 16260-16266
91. Engelke, G., Gutowski-Eckel, Z., Hammelmann, M. and Entian, K. D. (1992) Appl. Environ. Microbiol. 58, 3730-3743
92. Kaletta, C. and Entian, K. D. (1989) J. Bacteriol. 171, 1597-1601
93. Kuipers, O. P., Beerthuyzen, M. M., Siezen, R. J. and De Vos, W. M. (1993) Eur. J. Biochem. 216, 281-291
94. Siegers, K. and Entian, K. D. (1995) Appl. Environ. Microbiol. 61, 1082-1089
95. van der Meer, J. R., Polman, J., Beerthuyzen, M. M., Siezen, R. J., Kuipers, O. P. and De Vos, W. M. (1993) J. Bacteriol. 175, 2578-2588
96. Engelke, G., Gutowski-Eckel, Z., Kiesau, P., Siegers, K., Hammelmann, M. and Entian, K. D. (1994) Appl. Environ. Microbiol. 60, 814-825
97. Stock, J. B., Stock, A. M. and Mottonen, J. M. (1990) Nature 344, 395-400
98. Parkinson, J. S. and Kofoid, E. C. (1992) Annu. Rev. Genet. 26, 71-112
99. Wanner, B. L. (1992) J. Bacteriol. 174, 2053-2058
100. Gross, E., Kiltz, H. H. and Craig, L. C. (1973) Hoppe-Seylers Z. Physiol. Chem. 354, 799-801
101. Gutowski-Eckel, Z., Klein, C., Siegers, K., Bohm, K., Hammelmann, M. and Entian, K. D. (1994) Appl. Environ. Microbiol. 60, 1-11
102. Klein, C., Kaletta, C. and Entian, K. D. (1993) Appl. Environ. Microbiol. 59, 296-303
103. McGowan, S. J., Holden, M. T. G., Bycroft, B. W. and Salmond, G. P. C. (1999) Antonie van Leeuwenhoek 75, 135-141
104. Salmond, G. P. C., Bycroft, B. W., Stewart, G. and Williams, P. (1995) Mol. Microbiol. 16, 615-624
105. a Erratum. Mol. Microbiol. (1996) 19, 649
106. Bibb, M. J. (2005) Curr. Opin. Microbiol. 8, 208-215
107. Collmer, A. and Keen, N. T. (1986) Annu. Rev. Phytopathol. 24, 383-409
108. Byers, J. T., Lucas, C., Salmond, G. P. C. andWelch, M. (2002) J. Bacteriol. 184, 1163-1171
109. Jones, S., Yu, B., Bainton, N. J., Birdsall, M., Bycroft, B. W., Chhabra, S. R., Cox, A. J. R., Golby, P., Reeves, P. J., Stephens, S. et al. (1993) EMBO J. 12, 2477-2482
110. Fineran, P. C., Slater, H., Everson, L., Hughes, K. and Salmond, G. P. (2005) Mol. Microbiol. 56, 1495-1517
111. Gerber, N. N. and Lechevalier, M. P. (1964) Biochemistry 3, 598-602
112. Karnetova, J., Tax, J., Stajner, K., Vanek, Z. and Krumphanzl, V. (1983) Folia Microbiol. 28, 51-53
113. Giddens, S. R. and Bean, D. C. (2007) Int. J. Antimicrob. Agents 29, 93-97
114. Pierson, 3rd, L. S. and Thomashow, L. S. (1992) Mol. Plant-Microbe Interact. 5, 330-339
115. Wood, D. W., Gong, F., Daykin, M. M., Williams, P. and Pierson, 3rd, L. S. (1997) J. Bacteriol. 179, 7663-7670
116. Chin-A-Woeng, T. F. C., Bloemberg, G. V., Mulders, I. H. M., Dekkers, L. C. and Lugtenberg, B. J. J. (2000) Mol. Plant-Microbe Interact. 13, 1340-1345
117. Chin-A-Woeng, T. F. C., van den Broek, D., de Voer, G., van der Drift, K. M. G. M., Tuinman, S., Thomas-Oates, J. E., Lugtenberg, B. J. J. and Bloemberg, G. V. (2001) Mol. Plant-Microbe Interact. 14, 969-979
118. Horinouchi, S. and Beppu, T. (1992) Annu. Rev. Microbiol. 46, 377-392
119. Miyake, K., Horinouchi, S., Yoshida, M., Chiba, N., Mori, K., Nogawa, N., Morikawa, N. and Beppu, T. (1989) J. Bacteriol. 171, 4298-4302
120. Recio, E., Colinas, A., Rumbero, A., Aparicio, J. F. and Martin, J. F. (2004) J. Biol. Chem. 279, 41586-41593
121. Ohnishi, Y., Yamazaki, H., Kato, J.-y., Tomono, A. and Horinouchi, S. (2005) Biosci. Biotechnol. Biochem. 69, 431-439
122. Natsume, R., Ohnishi, Y., Senda, T. and Horinouchi, S. (2004) J. Mol. Biol. 336, 409-419
123. Nihira, T. (2002) in Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation (Fierro, F. and Martin, J.F., eds), pp. 99-119, Research Signpost, Trivandrum
124. Kitani, S., Yamada, Y. and Nihira, T. (2001) J. Bacteriol. 183, 4357-4363
125. Takano, E., Chakraburtty, R., Nihira, T., Yamada, Y. and Bibb, M. J. (2001) Mol. Microbiol. 41, 1015-1028
126. Wietzorrek, A. and Bibb, M. (1997) Mol. Microbiol. 25, 1181-1184
127. Recio, E., Aparicio, J. F., Rumbero, A. and Martin, J. F. (2006) Microbiology 152, 3147-3156
128. Anton, N., Mendes, M. V., Martin, J. F. and Aparicio, J. F. (2004) J. Bacteriol. 186, 2567-2575
129. Marketon, M. M., Glenn, S. A., Eberhard, A. and Gonzalez, J. E. (2003) J. Bacteriol. 185, 325-331
130. Von Bodman, S. B., Majerczak, D. R. and Coplin, D. L. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 7687-7692
131. Xavier, K. B. and Bassler, B. L. (2005) Nature 437, 750-753
132. Bassler, B. L., Greenberg, E. P. and Stevens, A. M. (1997) J. Bacteriol. 179, 4043-4045
133. Surette, M. G., Miller, M. B. and Bassler, B. L. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1639-1644
134. Schauder, S., Shokat, K., Surette, M. G. and Bassler, B. L. (2001) Mol. Microbiol. 41, 463-476
135. Bassler, B. L., Wright, M. and Silverman, M. R. (1994) Mol. Microbiol. 13, 273-286
136. Bassler, B. L., Wright, M. and Silverman, M. R. (1994) Mol. Microbiol. 12, 403-412
137. Freeman, J. A. and Bassler, B. L. (1999) Mol. Microbiol. 31, 665-677
138. Martin, M., Showalter, R. and Silverman, M. (1989) J. Bacteriol. 171, 2406-2414
139. Showalter, R. E., Martin, M. O. and Silverman, M. R. (1990) J. Bacteriol. 172, 2946-2954
140. Long, T., Tu, K. C., Wang, Y., Mehta, P., Ong, N. P., Bassler, B. L. and Wingreen, N. S. (2009) PLoS Biol. 7, e68
141. Wang, L., Li, J., March, J. C., Valdes, J. J. and Bentley, W. E. (2005) J. Bacteriol. 187, 8350-8360
142. DeLisa, M. P., Wu, C.-F., Wang, L., Valdes, J. J. and Bentley, W. E. (2001) J. Bacteriol. 183, 5239-5247
143. Sperandio, V., Mellies, J. L., Nguyen, W., Shin, S. and Kaper, J. B. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 15196-15201
144. Burgess, N. A., Kirke, D. F., Williams, P., Winzer, K., Hardie, K. R., Meyers, N. L., Aduse-Opoku, J., Curtis, M. A. and Camara, M. (2002) Microbiology 148, 763-772
145. Chung, W. O., Park, Y., Lamont, R. J., McNab, R., Barbieri, B. and Demuth, D. R. (2001) J. Bacteriol. 183, 3903-3909
146. Fong, K. P., Chung, W. O., Lamont, R. J. and Demuth, D. R. (2001) Infect. Immun. 69, 7625-7634
147. McNab, R., Ford, S. K., El-Sabaeny, A., Barbieri, B., Cook, G. S. and Lamont, R. J. (2003) J. Bacteriol. 185, 274-284
148. Taga, M. E., Semmelhack, J. L. and Bassler, B. L. (2001) Mol. Microbiol. 42, 777-793
149. Taga, M. E., Miller, S. T. and Bassler, B. L. (2003) Mol. Microbiol. 50, 1411-1427
150. Miller, M. B., Skorupski, K., Lenz, D. H., Taylor, R. K. and Bassler, B. L. (2002) Cell 110, 303-314
151. Zhu, J., Miller, M. B., Vance, R. E., Dziejman, M., Bassler, B. L. and Mekalanos, J. J. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 3129-3134
152. Finkelstein, R. A., Boesman-Finkelstein, M., Chang, Y. and Hase, C. C. (1992) Infect. Immun. 60, 472-478
153. Lyon, W. R., Madden, J. C., Levin, J. C., Stein, J. L. and Caparon, M. G. (2001) Mol. Microbiol. 42, 145-157
154. Ohtani, K., Hayashi, H. and Shimizu, T. (2002) Mol. Microbiol. 44, 171-179
155. Jones, M. B. and Blaser, M. J. (2003) Infect. Immun. 71, 3914-3919
156. Auger, S., Krin, E., Aymerich, S. and Gohar, M. (2006) Appl. Environ. Microbiol. 72, 937-941
157. Hilgers, M. T. and Ludwig, M. L. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 11169-11174
158. Ruzheinikov, S. N., Das, S. K., Sedelnikova, S. E., Hartley, A., Foster, S. J., Horsburgh, M. J., Cox, A. G., McCleod, C. W., Mekhalfia, A., Blackburn, G. M. et al. (2001) J. Mol. Biol. 313, 111-122
159. Winzer, K., Hardie, K. R. and Williams, P. (2002) Curr. Opin. Microbiol. 5, 216-222
160. Pei, D. and Zhu, J. (2004) Curr.Opin. Chem. Biol. 8, 492-497
161. Lombardia, E., Rovetto, A. J., Arabolaza, A. L. and Grau, R. R. (2006) J. Bacteriol. 188, 4442-4452
162. Chu, F., Kearns, D. B., Branda, S. S., Kolter, R. and Losick, R. (2006) Mol. Microbiol. 59, 1216-1228
163. Hamon, M. A. and Lazazzera, B. A. (2001) Mol. Microbiol. 42, 1199-1209
164. Hartman, G. and Wise, R. (1998) Lancet 351, 848-849
165. Hentzer, M. and Givskov, M. (2003) J. Clin. Invest. 112, 1300-1307
166. Riedel, K., Hentzer, M., Geisenberger, O., Huber, B., Steidle, A., Wu, H., Hoiby, N., Givskov, M., Molin, S. and Eberl, L. (2001) Microbiology 147, 3249-3262
167. Roche, D. M., Byers, J. T., Smith, D. S., Glansdorp, F. G., Spring, D. R. and Welch, M. (2004) Microbiology 150, 2023-2028
168. Dong, Y.-H., Gusti, A. R., Zhang, Q., Xu, J.-L. and Zhang, L.-H. (2002) Appl. Environ. Microbiol. 68, 1754-1759
169. Leadbetter, J. R. and Greenberg, E. P. (2000) J. Bacteriol. 182, 6921-6926
170. Liu, D., Momb, J., Thomas, P. W., Moulin, A., Petsko, G. A., Fast, W. and Ringe, D. (2008) Biochemistry 47, 7706-7714
171. Dong, Y.-H., Zhang, X.-F., Xu, J.-L. and Zhang, L.-H. (2004) Appl. Environ. Microbiol. 70, 954-960
172. Xu, X.-H. N., Wan, Q., Kyriacou, S. V., Brownlow, W. J. and Nowak, M. E. (2003) Biochem. Biophys. Res. Commun. 305, 941-949
173. Smith, K. M., Bu, Y. and Suga, H. (2003) Chem. Biol. 10, 563-571
174. Smith, K. M., Bu, Y. and Suga, H. (2003) Chem. Biol. 10, 81-89
175. Ikeda, T., Kajiyama, K., Kita, T., Takiguchi, N., Kuroda, A., Kato, J. and Ohtake, H. (2001) Chem. Lett. 30, 314-315
176. Ishida, T., Ikeda, T., Takiguchi, N., Kuroda, A., Ohtake, H. and Kato, J. (2007) Appl. Environ. Microbiol. 73, 3183-3188
177. Kim, C., Kim, J., Park, H.-Y., Park, H.-J., Lee, J., Kim, C. and Yoon, J. (2008) Appl. Microbiol. Biotechnol. 80, 37-47
178. Kim, C., Kim, J., Park, H.-Y., Lee, J.-H., Park, H.-J., Kim, C. K. and Yoon, J. (2009) Appl. Microbiol. Biotechnol., 10.1007/s00253-009-1954-3
179. Morohoshi, T., Shiono, T., Takidouchi, K., Kato, M., Kato, N., Kato, J. and Ikeda, T. (2007) Appl. Environ. Microbiol. 73, 6339-6344
180. Swift, S., Lynch, M. J., Fish, L., Kirke, D. F., Tomas, J. M., Stewart, G. S. A. B. and Williams, P. (1999) Infect. Immun. 67, 5192-5199
181. Qin, Y., Luo, Z.-Q. and Farrand, S. K. (2004) J. Biol. Chem. 279, 40844-40851
182. Zhu, J., Beaber, J. W., More, M. I., Fuqua, C., Eberhard, A. and Winans, S. C. (1998) J. Bacteriol. 180, 5398-5405
183. Reverchon, S., Chantegrel, B., Deshayes, C., Doutheau, A. and Cotte-Pattat, N. (2002) Bioorg. Med. Chem. Lett. 12, 1153-1157
184. Manefield, M., de Nys, R., Kumar, N., Roger, R., Givskov, M., Peter, S. and Kjelleberg, S. (1999) Microbiology 145, 283-291
185. Rasmussen, T. B., Manefield, M., Andersen, J. B., Eberl, L., Anthoni, U., Christophersen, C., Steinberg, P., Kjelleberg, S. and Givskov, M. (2000) Microbiology 146, 3237-3244
186. Maximilien, R., de Nys, R., Holmstrom, C., Gram, L., Givskov, M., Crass, K., Kjelleberg, S. and Steinberg, P. D. (1998) Aquat. Microb. Ecol. 15, 233-246
187. de Nys, R.,Wright, A. D., König, G. M. and Sticher, O. (1993) Tetrahedron 49, 11213-11220
188. Givskov, M., de Nys, R., Manefield, M., Gram, L., Maximilien, R., Eberl, L., Molin, S., Steinberg, P. D. and Kjelleberg, S. (1996) J. Bacteriol. 178, 6618-6622
189. Daniels, R., Vanderleyden, J. and Michiels, J. (2004) FEMS Microbiol. Rev. 28, 261-289
190. Lindum, P. W., Anthoni, U., Christophersen, C., Eberl, L., Molin, S. and Givskov, M. (1998) J. Bacteriol. 180, 6384-6388
191. Manefield, M., Rasmussen, T. B., Henzter, M., Andersen, J. B., Steinberg, P., Kjelleberg, S. and Givskov, M. (2002) Microbiology 148, 1119-1127
192. Gram, L., de Nys, R., Maximilien, R., Givskov, M., Steinberg, P. and Kjelleberg, S. (1996) Appl. Environ. Microbiol. 62, 4284-4287
193. Ren, D., Sims, J. J. and Wood, T. K. (2001) Environ. Microbiol. 3, 731-736
194. Ren, D., Zuo, R., Gonzalez Barrios, A. F., Bedzyk, L. A., Eldridge, G. R., Pasmore, M. E. and Wood, T. K. (2005) Appl. Environ. Microbiol. 71, 4022-4034
195. Hjelmgaard, T., Persson, T., Rasmussen, T. B., Givskov, M. and Nielsen, J. (2003) Bioorg. Med. Chem. 11, 3261-3271
196. Lonn-Stensrud, J., Landin, M. A., Benneche, T., Petersen, F. C. and Scheie, A. A. (2009) J. Antimicrob. Chemother. 63, 309-316
197. Wu, H., Song, Z., Hentzer, M., Andersen, J. B., Molin, S., Givskov, M. and Hoiby, N. (2004) J. Antimicrob. Chemother. 53, 1054-1061
198. Martinelli, D., Grossmann, G., Sequin, U., Brandl, H. and Bachofen, R. (2004) BMC Microbiol. 4, 25
199. Gonzalez, J. E. and Marketon, M. M. (2003) Microbiol. Mol. Biol. Rev. 67, 574-592
200. Loh, J., Pierson, E. A., Pierson, L. S., Stacey, G. and Chatterjee, A. (2002) Curr. Opin. Plant Biol. 5, 285-290
201. Fray, R. G., Throup, J. P., Daykin, M., Wallace, A., Williams, P., Stewart, G. S. A. B. and Grierson, D. (1999) Nat. Biotech. 17, 1017-1020
202. Mae, A., Montesano, M., Koiv, V. and Palva, E. T. (2001) Mol. Plant-Microbe Interact. 14, 1035-1042
203. Toth, I. K., Newton, J. A., Hyman, L. J., Lees, A. K., Daykin, M., Ortori, C., Williams, P. and Fray, R. G. (2004) Mol. Plant-Microbe Interact. 17, 880-887
204. Dong, Y.-H.,Wang, L.-H., Xu, J.-L., Zhang, H.-B., Zhang, X.-F. and Zhang, L.-H. (2001) Nature 411, 813-817
205. Zhou, Y., Choi, Y.-L., Sun, M. and Yu, Z. (2008) Appl. Microbiol. Biotechnol. 80, 563-572
206. Horowitz Brown, S., Zarnowski, R., Sharpee, W. C. and Keller, N. P. (2008) Appl. Environ. Microbiol. 74, 5674-5685
207. Raina, S. (2008) The effect of γ-butyrolactone as quorumsensing molecule on secondary metabolite production in filamentous fungi, Ph.D. Thesis, University of Westminster, London
208. Keller, L. and Surette, M. G. (2006) Nat. Rev. Microbiol. 4, 249-258
209. Diggle, S. P., Gardner, A., West, S. A. and Griffin, A. S. (2007) Philos. Trans. R. Soc. B Biol. Sci. 362, 1241-1249
210. Swift, S., Karlyshev, A. V., Fish, L., Durant, E. L., Winson, M. K., Chhabra, S. R., Williams, P., Macintyre, S. and Stewart, G. S. (1997) J. Bacteriol. 179, 5271-5281
211. McGowan, S., Sebaihia, M., Jones, S., Yu, B., Bainton, N., Chan, P. F., Bycroft, B., Stewart, G. S. A. B., Williams, P. and Salmond, G. P. C. (1995) Microbiology 141, 541-550
212. Pearson, J. P., Pesci, E. C. and Iglewski, B. H. (1997) J. Bacteriol. 179, 5756-5767