The INFUSE-Morphine Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneously Administered Morphine in Patients with Advanced Illness

Journal of Pain and Symptom Management

Volumn 38, Issue 5, 2009, Pages 663-672

  Thomas, Jay R ^a   Wallace, Mark S ^b   Yocum, Richard C ^c   Vaughn, Daniel E ^d   Haller, Michael F ^d   Flament, Jocelyne ^e  

^a City of Hope ^*  (United States)

^b School of Medicine   (United States)

^c Rockwell Medical Technologies Inc   (United States)

^d Halozyme Therapeutics Inc   (United States)

^e EORTC DATA CENTER   (Belgium)

Author keywords

difficult venous access; hospice; hospice care; interstitial; M6G; pain; palliative care; parenteral; pharmacokinetics; Subcutaneous

Indexed keywords

HYLENEX; MORPHINE; MORPHINE 6 GLUCURONIDE; PLACEBO; RECOMBINANT ENZYME; RECOMBINANT HUMAN HYALURONIDASE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIPLOPIA; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG POTENTIATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HICCUP; HUMAN; HYPOTENSION; INJECTION SITE BLEEDING; INJECTION SITE EDEMA; INJECTION SITE ERYTHEMA; INJECTION SITE INDURATION; INJECTION SITE IRRITATION; INJECTION SITE PAIN; INJECTION SITE PRURITUS; INJECTION SITE RASH; MALE; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; UNSPECIFIED SIDE EFFECT; XEROSTOMIA;

ABSORPTION; ADULT; AGED; ANALGESICS, OPIOID; BIOTRANSFORMATION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYALURONOGLUCOSAMINIDASE; INJECTIONS, SUBCUTANEOUS; MALE; MIDDLE AGED; MORPHINE; PALLIATIVE CARE; RECOMBINANT PROTEINS;

EID: 70350534451     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2009.03.009     Document Type: Article

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