Antiarrhythmic and arrhythmogenic action of inosine in experimental ventricular tachyarrhythmias

Archivos de Cardiologia de Mexico

Volumn 79, Issue 3, 2009, Pages 175-181

  De Micheli, Alfredo ^a   Pastelín, Gustavo ^a   Domínguez, Rafael Chávez ^a   Torres, Pedro Iturralde ^a   Medrano, Gustavo A ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

Author keywords

Inosine; Inosine's antiarrhythmic effects; Inosine's arrhytmogenic effects

Indexed keywords

ACONITINE; ADENOSINE; INOSINE; PENTOBARBITAL; PHENOL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DOG; HEART LEFT VENTRICLE; HEART MUSCLE INJURY; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; NONHUMAN; SINUS RHYTHM; SUPERIOR CAVA VEIN;

ANIMALS; DOGS; INOSINE; TACHYCARDIA, VENTRICULAR;

EID: 70350509801     PISSN: 14059940     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Brandan NC, Aispuru G. Metabolismo de compuestos hidrogenados. http;//med.unne.edu.ar/catedras/bioquimica/pdf/nitra.pdf.
2. Belardinelli L, Lerman BB. Adenosine: cardiac electrophysiology. Pacing Clin Electrophysiol 1991;14:1672-1680
3. Belardinelli L, Shreyock KJC , Pelleg A. Cardiac electrophysiologic properties of adenosine. Coron Art Dis 1992;3:1122-1126
4. Pelleg A, Porter RS. Pharmacology of adenosine. Pharmacotherapy 1990;10:157-174
5. DiMarco J, Miles W, Akhtar M, Milstein S, Sharma AD, Platia E, et al. Adenosine for paroxysmal supraventricular tachycardia. Dose ranging and comparison with verapamil. Assessment in placebo-controlled, multicenter trials The adenosine for PSVT Study Group..Ann Intern Med 1990;113:104-110
6. Froldi L, Belardinelli L. Species dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological complications. Circ Res 1990;67:960-978
7. Clemo HF, Belardinelli L. Effects of adenosine on atrioventricular conduction. I:Site and characterization of adenosine action in the guinea pig atrioventricular node. Circ Res 1986;59:427-436
8. Chen Y, Barche RJ. Adenosine. A modulator of the cardiac response to stress. Circ Res 2003;93:691-693
9. Virág L, Szabó C. Purines inhibit poly (ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J 2001;15:99-107. (Pubitemid 32061660)
10. Görge B, Kurz T, Katus HA, Richardt G. Endogenous adenosine suppresses norepinephrine-induced ventricular arrhythmias in rat heart. Basic Res Cardiol 1998;93:264-268 (Pubitemid 28422953)
11. Friedrichs GS, Merrill GF. Adenosine deaminase and adenosine attenuate ventricular arrhythmias caused by norepinephrine. Am J Physiol 1991;260(3Pt): H979-84.
12. West G A, Isenberg G, Belardinelli L. Antagonism of forskolin effects by adenosine in guinea pig isolated hearts and ventricular myocytes: evidence that adrenergic effects of adenosine are due to inhibition of adenylate cyclase. Am J Physiol 1986;250:H769-77.
13. Rodríguez-Castellano T J, Iturralde-Torres P, de Micheli A, Ramírez-Insunza J M, Ramírez J C, Corona Sapien C, et al. Respuesta de la taquicardia ventricular a la administración de adenosina. Arch Inst Cardiol Mex 1994;64:445-454
14. De Micheli A, Chávez-Domínguez R, Iturralde-Torres P, Pastelín G, Medrano G A. Efectos tempranos y tardíos de.la adenosina en taquicardias ventriculares experimentales. Rev Esp Cardiol 2005;58:159-166 (Pubitemid 40439574)
15. Lerman BB, Belardlnelli L. Cardiac electrophysiology of adenosine. Circulation 1991;83:1499-1509
16. Lubbe W F, Gilchrist A I, Holland R K, Pybus J. Adenine nucleotides and ventricular fibrillation. J Mol Cell Cardiol 1987;19Suppl5:23-33. (Pubitemid 18013590)
17. Szabó G, Stumpf N, Radovits F, Sonnenberg K, Gerö D, Hagl S, et al. Effects of inosine on reperfusion injury after heart transplantation. Eur J Cardiothoracic Surg 2006;30:96-102. (Pubitemid 43850335)
18. Martïnez M: Personal communication.
19. Garrat C J, Antoniou M J, Ward DE, Camm A J. Use of intravenous adenosine in sinus rhythm as a diagnostic test for latent preexcitation. Am J Cardiol 1990;65:868-873
20. Bases farmacolögicas de la terapéutica. J G Hardman, L E Limbird, editors. Mëxico. McGraw-Hill Interamericana. 10th Ed. Vol I. p 958, Cuadro 35-3.
21. Alunni S, Orrù M, Ottavi L. A study on the inhibition of adenosine deaminase enzyme. J Enzyme Inhib Med Chem 2008;23:182-189
22. DiMarco J P. Electrophysiology of adenosine. J Cardiovasc Electrophysiol 1990;1:340-348
23. Haines D P, Lerman BB, DiMarco J P. Intravenous adenosine shortens atrial refractoriness in man. Circulation 1988;78 Suppl II:153.
24. de Micheli A, Iturralde Torres P, Pastelin G. Adenosina en taquicardias ventriculares inducidas. Conmunication to XX Congreso Mexicano de Cardiologìa. Mérida, Yucatàn, November 1-5,1997. Arch Inst Cardiol Mex 1997;67 Suppl I:No.224.
25. DiMarco J P, Lerman BB, Haines D F.Effects of adenosine on antegrade conduction in patients with manifest and concealed pre-excitation. Abstract. Circulation 1987;76:IV-67.
26. Alegret J M, Viñolas X, Palazón O, Vernls J M, Ferrer A, Oter R. Preexcitación intermitente tras administración de adenosina. Rev Esp Cardiol 2000;53:1132-1135 (Pubitemid 30680757)