Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT)

Journal of Cellular Biochemistry

Volumn 108, Issue 4, 2009, Pages 926-934

  Shi, Song Lin ^a   Li, Qi Fu ^a   Liu, Qing Rong ^b   Xu, Dong Hui ^c   Tang, Jian ^a   Liang, Ying ^a   Zhao, Zhen Li ^a   Yang, Li Ming ^a  

^a XIAMEN UNIVERSITY   (China)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cell differentiation; Huaman osteosarcoma MG 63 cells; Nuclear matrix; Prohibitin

Indexed keywords

CINNAMIC ACID; GENE PRODUCT; GINSENOSIDE RG 1; PROHIBITIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; TANSHINONE IIA;

AMINO ACID SEQUENCE; ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS MATRIX; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; HUMAN; HUMAN CELL; INTERMEDIATE FILAMENT; NUCLEOCYTOPLASMIC TRANSPORT; ONCOGENE C FOS; ONCOGENE C MYC; OSTEOSARCOMA CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL NUCLEUS; CINNAMATES; CYTOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GINSENOSIDES; HUMANS; ONCOGENES; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

PANAX GINSENG;

EID: 70350509123     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22324     Document Type: Article

References (28)

1. Buchmann AM, Swaminathan S, Thimmapaya B. 1998. Regulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor protein. Mol Cell Biol 18:4565-4576. (Pubitemid 28343041)
2. Capco DG, Wan KM, Penman S. 1982. The nuclear matrix: Three-dimensional architecture and protein composition. Cell 29:847-858.
3. Dixit VD, Sridaran R, Edmonsond MA, Taub D, Thompson WE. 2003. Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin. Endocrinology 144:1496-1505. (Pubitemid 36428492)
4. Fusaro G, Wang S, Chellappan S. 2002. Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis. Oncogene 21:4539-4548. (Pubitemid 34785730)
5. Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S. 2003. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J Biol Chem 278:47853-47861. (Pubitemid 37523233)
6. Gao JG, Han YR, Jiao RJ, Zhai ZH. 1994. The intermediate filament-lamina-nuclear matrix system of ES-M13 cells. Shi Yan Sheng Wu Xue Bao 27:463-475.
7. Haggerty TJ, Zeller KI, Osthus RC, Wonsey DR, Dang CV. 2003. A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites. Proc Natl Acad Sci USA 100:5313-5318.
8. Helms S. 2004. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev 9:259-274. (Pubitemid 39299200)
9. Jang JS, Cho HY, Lee YJ, Ha WS, Kim HW. 2004. The differential proteome profile of stomach cancer: Identification of the biomarker candidates. Oncol Res 14:491-499.
10. Li QF, Shi SL, Liu QR, Tang J, Song J, Liang Y. 2008. Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: Nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin. Int J Biochem Cell Biol 40:1918-1929.
11. Li QF, Wang GH, Shi SL, Ma ZY, Lin CJ, Jing GJ. 2009. Effects of the combination of ginsenoside Rg1, cinnamic acid and tanshinone IIA on the morphology and terminal differentiation of MG-63 cells in vitro. Aata Anatomic Sinica 40:13-19.
12. Loukas A, Maizels RM. 1998. Cloning and characterisation of a prohibitin gene from infective larvae of the parasitic nematode Toxocara canis. DNA Seq 9:323-328. (Pubitemid 29120362)
13. Menssen A, Hermeking H. 2002. Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes. Proc Natl Acad Sci USA 99:6274-6279. (Pubitemid 34493302)
14. Michishita E, Kurahashi T, Suzuki T, Fukuda M, Fujii M, Hirano H, Ayusawa D. 2002. Changes in nuclear matrix proteins during the senescence-like phenomenon induced by 5-chlorodeoxyuridine in HeLa cells. Exp Gerontol 37:885-890. (Pubitemid 34665478)
15. Nickerson JA, Krockmalnic G, Wan KM, Penman S. 1997. The nuclear matrix revealed by eluting chromatin from a cross-linked nucleus. Proc Natl Acad Sci USA 94:4446-4450. (Pubitemid 27194261)
16. Nijtmans LGJ, de Jong L, Sanz MA, Coates PJ, Berden JA, Back JW, Muijsers AO, van der Spek H, Grivell LA. 2000. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 19:2444-2451.
17. Nijtmans LGJ, Sanz MA, Grivell LA, Coates PJ. 2002. The mitochondrial PHB complex: Roles in mitochondrial respiratory complex assembly, ageing and degenerative disease. Cell Mol Life Sci 59:143-155.
18. Piper PW, Jones GW, Bringloe D, Harris N, Maclean M, Mollapour M. 2002. The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell 1:149-157.
19. Qi YJ, Chiu JF, Wang LD, Kwong DLW, He QY. 2005. Comparative proteomic analysis of esophageal squamous cell carcinoma. Proteomics 5:2960-2971. (Pubitemid 41059772)
20. Rastogi S, Joshi B, Fusaro G, Chellappan S. 2006. Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism. J Biol Chem 281:2951-2959. (Pubitemid 43845762)
21. Sanz MA, Tsang WY, Willems EM, Grivell LA, Lemire BD, van der Spek H, Nijtmans LGJ. 2003. The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans. J Biol Chem 278:32091-32099.
22. Sato T, Saito H, Swensen J, Olifant A, Wood C, Danner D, Sakamoto T, Takita K, Kasumi F, Miki Y, Skolnick M, Nakamura Y. 1992. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. Cancer Res 52:1643-1646.
23. Snedden WA, Fromm H. 1997. Characterization of the plant homologue of prohibitin, a gene associated with antiproliferative activity in mammalian cells. Plant Mol Biol 33:753-756. (Pubitemid 27155931)
24. Sun LG, Liu LY, Yang XJ, Wu ZG. 2004. Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation. J Cell Sci 117:3021-3029.
25. Tsai HW, Chow NH, Lin CP, Chan SH, Chou CY, Ho CL. 2006. The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma. Hum Pathol 37:198-204.
26. Wang S, Fusaro G, Padmanabhan J, Chellappan SP. 2002a. Prohibitin colocalizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene 21:8388-8396. (Pubitemid 36054881)
27. Wang S, Zhang BH, Faller DV. 2002b. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J 21:3019-3028. (Pubitemid 34670386)
28. Yun TK. 2001. Panax ginseng - A non-organ-specific cancer preventive? Lancet Oncol 2:49-55.