A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs

Journal of Pharmacological Sciences

Volumn 111, Issue 2, 2009, Pages 211-215

  Ishitsuka, Yoichi ^a   Moriuchi, Hiroshi ^b   Isohama, Yoichiro ^a   Tokunaga, Hidehiro ^c   Hatamoto, Keita ^a   Kurita, Sumika ^a   Irikura, Mitsuru ^a   Iyama, Ken Ichi ^c   Irie, Tetsumi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b SOJO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Lung injury; Oleic acid; Ozagrel

Indexed keywords

INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OLEIC ACID; OZAGREL; EOSIN; MAY GRUNWALD GIEMSA; MAY-GRUNWALD GIEMSA; METHACRYLIC ACID DERIVATIVE; METHYLENE BLUE; PROTEIN; THROMBOXANE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; LEUKOCYTE; LUNG INJURY; MACROPHAGE; MALE; NEUTROPHIL; NONHUMAN; PROPHYLAXIS; PROTEIN EXPRESSION; ACUTE LUNG INJURY; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; LEUKOCYTE COUNT; LUNG LAVAGE; METABOLISM; METHODOLOGY; STAINING; TIME;

ACUTE LUNG INJURY; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CCL2; EOSINE YELLOWISH-(YS); GUINEA PIGS; INTERLEUKIN-8; LEUKOCYTE COUNT; MACROPHAGES; MALE; METHACRYLATES; METHYLENE BLUE; NEUTROPHILS; OLEIC ACID; PROTEINS; RNA, MESSENGER; STAINING AND LABELING; THROMBOXANE A2; TIME FACTORS;

EID: 70350502640     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09128SC     Document Type: Article

References (15)

1. 2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2007;176:795-804.
2. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-1349.
3. Park GY, Christman JW. Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases. Am J Physiol Lung Cell Mol Physiol. 2006;290: L797-L805.
4. 2 synthase inhibitor, in guinea-pigs. J Pharm Pharmacol. 2004;56:513-520.
5. Allen TC, Fudala R, Nash SE, Kurdowska A. Anti-interleukin 8 autoantibody: interleukin 8 immune complexes visualized by laser confocal microscopy in injured lung. Arch Pathol Lab Med. 2007;131:452-456.
6. Goodman RB, Strieter RM, Martin DP, Steinberg KP, Milberg JA, Maunder RJ, et al. Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am J Respir Crit Care Med. 1996;154:602-611. (Pubitemid 26327279)
7. 2) receptor blockade suppresses monocyte chemoattractant protein-1 (MCP-1) expression by stimulated vascular endothelial cells. Clin Exp Immunol. 2000;120:71-78.
8. Keelan JA, Sato TA, Gupta DK, Marvin KW, Mitchell MD. Prostanoid stimulation of cytokine production in an amnionderived cell line: evidence of a feed-forward mechanism with implications for term and preterm labor. J Soc Gynecol Investig. 2000;7:37-44.
9. Yang C, Ishitsuka Y, Moriuchi H, Golbidid S, Jine Z, Irikura M, et al. Protection afforded by a herbal medicine, Sho-seiryu-to (TJ-19), against oleic acid-induced acute lung injury in guineapigs. J Pharm Pharmacol. 2009;61:925-932.
10. Matute-Bello G, Frevert CW, Martin TR. Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;295:L379-L399.
11. Katagiri H, Ito Y, Ishii K, Hayashi I, Suematsu M, Yamashina S, et al. Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice. Hepatology. 2004;39:139-150. (Pubitemid 38461476)
12. 2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells. Clin Exp Immunol. 1998;112:464-470.
13. Slotman GJ, Burchard KW, D'Arezzo A, Gann DS. Ketoconazole prevents acute respiratory failure in critically ill surgical patients. J Trauma. 1988;28:648-654. (Pubitemid 18143694)
14. Yu M, Tomasa G. A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. Crit Care Med. 1993;21:1635-1642. (Pubitemid 23332080)
15. The ARDS Network. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2000;283:1995-2002.