Potential biomarkers of smoked fentanyl utilizing pyrolysis gas chromatography-mass spectrometry

Journal of Analytical Toxicology

Volumn 33, Issue 8, 2009, Pages 418-422

  Nishikawa, Rona K ^a   Bell, Suzanne C ^a   Kraner, James C ^b   Callery, Patrick S ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b Office of the Chief Medical Examiner   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FENTANYL; HELIUM; HYDROCARBON; POLYMER;

CONFERENCE PAPER; MASS SPECTROMETRY; PYROLYSIS; SMOKING;

EID: 70350499856     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/33.8.418     Document Type: Conference Paper

References (22)

1. Control of a chemical precursor used in the illicit manufacture of fentanyl as a list I chemical. Fed. Regist. 72: 20039-20047 (2007).
2. J.J. Kuhlman, Jr., R. McCaulley, T.J. Valouch, and G.S. Behonick. Fentanyl use, misuse, and abuse: a summary of 23 postmortem cases. J. Anal. Toxicol. 27: 499-504 (2003).
3. M. Martin, J. Hecker, R. Clark, J. Frye, D. Jehle, E.J. Lucid, and F. Harchelroad. China white epidemic: an eastern United States emergency department experience. Ann. Emerg. Med. 20: 158-164 (1991).
4. T.L. Martin, K.L. Woodall, and B.A. McLellan. Fentanyl-related deaths in Ontario, Canada: toxicological findings and circumstances of death in 112 cases (2002-2004). J. Anal. Toxicol. 30: 603-610 (2006).
5. H. Schumann, T. Erickson, T.M. Thompson, J.L. Zautcke, and J.S. Denton. Fentanyl epidemic in Chicago, Illinois, and surrounding Cook County. Clin. Toxicol. 46: 501-506 (2008).
6. J.E. Smialek, B. Levine, L. Chin, S.C. Wu, and A.J. Jenkins. A fentanyl epidemic in Maryland 1992. J. Forensic Sci. 39: 159-164 (1994).
7. J.G. Thompson, A.M. Baker, A.H. Bracey, J. Seningen, J.S. Kloss, A.Q. Strobl, and F.S. Apple. Fentanyl concentrations in 23 postmortem cases from the Hennepin County medical examiner's office. J. Forensic Sci. 52: 978-981 (2007).
8. K.L. Woodall, T.L. Martin, and B.A. McLellan. Oral abuse of fentanyl patches (Duragesic): seven case reports. J. Forensic Sci. 53: 222-225 (2008).
9. A.M. Tharp, R.E. Winecker, and D.C. Winston. Fatal intravenous fentanyl abuse: four cases involving extraction of fentanyl from transdermal patches. Am. J. Forensic Med. Pathol. 25: 178-181 (2004).
10. M.L. Arvanitis and R.C. Satonik. Transdermal fentanyl abuse and misuse. Am. J. Emerg. Med. 20: 58-59 (2002).
11. T.P. Coon, M. Miller, D. Kaylor, and K. Jones-Spangle. Rectal insertion of fentanyl patches: a new route of toxicity. Ann. Emerg. Med. 46: 473 (2005).
12. K.A. Marquardt and R.S. Tharratt. Inhalation abuse of fentanyl patch. Clin. Toxicol. 32: 75-78 (1994).
13. Y. Meng, A.H. Lichtman, D.T. Bridgen, and B.R. Martin. Inhalation studies with drugs of abuse. NIDA Res. Monogr. 173: 201-224 (1997).
14. D.R. Wesson and P. Washburn. Current patterns of drug abuse that involve smoking. NIDA Res. Monogr. 99: 5-11 (1990).
15. N.L. Benowitz. Clinical pharmacology of inhaled drugs of abuse: implications in understanding nicotine dependence. NIDA Res. Monogr. 99: 12-29 (1990).
16. M. Gayton-Ely, D.M. Shakleya, and S.C. Bell. Application of a pyroprobe to simulate smoking and metabolic degradation of abused drugs through analytical pyrolysis. J. Forensic Sci. 52: 473-478 (2007).
17. Physician's Desk Reference, 60th ed. Thomson PDR, Montvale, NJ, 2006, p 2448.
18. R.B. Labroo, M.F. Paine, K.E. Thummel, and E.D. Kharasch. Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. Drug Metab. Dispos. 25: 1072-1080 (1997).
19. +, a metabolite of MPTP, by brain synaptosomes. Biochem. Biophys. Res. Commun. 128(3): 1228-1232 (1985).
20. + binds to neuromelanin. Science 231: 987-989 (1986).
21. +): identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci. Lett. 48(1): 87-92 (1984).
22. H. Moehrle and D. Ottersbach. Natriumquecksilberedetatdehydrierung N-aliphatisch substituierter 1,2,3,6-tetrahydropyridinderivate. Arch. Pharmazie 323: 109-115 (1990).