Insulin with chondroitinase ABC treats the rat model of acute spinal cord injury

Journal of International Medical Research

Volumn 37, Issue 4, 2009, Pages 1097-1107

  Yang, Y G ^a   Jiang, Dian Ming ^a   Quan, Z X ^a   Ou, Y S ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Acute spinal cord injury; Axon regrowth; Chondroitinase ABC; Growth associated protein 43; Insulin; Rat model

Indexed keywords

C 2905 2UN; CHONDROITIN ABC LYASE; INSULIN; METHYLPREDNISOLONE; NEUROMODULIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; LOCOMOTION; MALE; MOTOR PERFORMANCE; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; TREATMENT RESPONSE; ACUTE DISEASE; ANIMAL; CELL PROLIFERATION; CONVALESCENCE; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECT; ELECTROMYOGRAPHY; EVOKED RESPONSE; METABOLISM; MOTOR ACTIVITY; NERVE CONDUCTION; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACUTE DISEASE; ANIMALS; APOPTOSIS; AXONS; CELL PROLIFERATION; CHONDROITIN ABC LYASE; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ELECTROMYOGRAPHY; EVOKED POTENTIALS; FEMALE; GAP-43 PROTEIN; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MOTOR ACTIVITY; NEURAL CONDUCTION; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD INJURIES;

EID: 70350494253     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000903700414     Document Type: Article

References (32)

1. Jiang JY, Feng H, Fu Z, et al: Violent head trauma in China: report of 2254 cases. Surg Neurol 2007; 68(suppl 2): S2-S5. (Pubitemid 350122716)
2. Schwab ME: Repairing the injured spinal cord. Science 2002; 295: 1029-1031.
3. Filbin MT: Axon regeneration: vaccinating against spinal cord injury. Curr Biol 2000; 10: R100-R103. (Pubitemid 30115734)
4. De Winter F, Oudega M, Lankhorst AJ, et al: Injury-induced class 3 semaphorin expression in the rat spinal cord. Exp Neurol 2002; 175: 61-75. (Pubitemid 34507910)
5. Properzi F, Carulli D, Asher RA, et al: Chondroitin 6-sulphate synthesis is upregulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia. Eur J Neurosci 2005; 21: 378-390. (Pubitemid 40204241)
6. Rouleau P, Ung RV, Lapointe NP, et al: Hormonal and immunological changes in mice after spinal cord injury. J Neurotrauma 2007; 24: 367-378. (Pubitemid 46492157)
7. Brange J, Langkjoer L: Insulin structure and stability. Pharm Biotechnol 1993; 5: 315-350.
8. Costacou T, Mayer-Davis EJ: Nutrition and prevention of type 2 diabetes. Annu Rev Nutr 2003; 23: 147-170.
9. Colberg SR: Physical activity, insulin action, and diabetes prevention and control. Curr Diabetes Rev 2007; 3: 176-184. (Pubitemid 47244062)
10. Zhao Y, Xiao Z, Gao Y, et al: Insulin rescues ES cell-derived neural progenitor cells from apoptosis by differential regulation of Akt and ERK pathways. Neurosci Lett 2007; 429: 49-54. (Pubitemid 350123567)
11. Wu XH, Yang SH, Duan DY, et al: Antiapoptotic effect of insulin in the control of cell death and neurologic deficit after acute spinal cord injury in rats. J Neurotrauma 2007; 24: 1502-1512.
12. Morgenstern DA, Asher RA, Fawcett JW: Chondroitin sulphate proteoglycans in the CNS injury response. Prog Brain Res 2002; 137: 313-332.
13. Snow DM, Lemmon V, Carrino DA, et al: Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol 1990; 109: 111-130. (Pubitemid 20226710)
14. Barritt AW, Davies M, Marchand F, et al: Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci 2006; 26: 10856-10867. (Pubitemid 44776842)
15. Bradbury EJ, Moon LD, Popat RJ, et al: Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 2002; 416: 636-640. (Pubitemid 34406764)
16. Ikegami T, Nakamura M, Yamane J, et al: Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. Eur J Neurosci 2005; 22: 3036-3046. (Pubitemid 43001987)
17. Yick LW, Cheung PT, So KF, et al: Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC. Exp Neurol 2003; 182: 160-168.
18. Caggiano AO, Zimber MP, Ganguly A, et al: Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord. J Neurotrauma 2005; 22: 226-239. (Pubitemid 40333517)
19. Houle JD, Tom VJ, Mayes D, et al: Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J Neurosci 2006; 26: 7405-7415. (Pubitemid 44315209)
20. Fouad K, Schnell L, Bunge MB, et al: Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J Neurosci 2005; 25: 1169-1178. (Pubitemid 40268958)
21. Aarts LH, Schotman P, Verhaagen J, et al: The role of the neural growth associated protein B-50/GAP-43 in morphogenesis. Adv Exp Med Biol 1998; 446: 85-106. (Pubitemid 128701732)
22. Li GL, Farooque M, Holtz A, et al: Increased expression of growth-associated protein 43 immunoreactivity in axons following compression trauma to rat spinal cord. Acta Neuropathol 1996; 92: 19-26. (Pubitemid 26192078)
23. Oestreicher AB, De Graan PN, Gispen WH, et al: B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system. Prog Neurobiol 1997; 53: 627-686.
24. Huang WC, Kuo WC, Cherng JH, et al: Chondroitinase ABC promotes axonal regrowth and behavior recovery in spinal cord injury. Biochem Biophys Res Commun 2006; 349: 963-968. (Pubitemid 44380193)
25. Tencer AF, Ferguson RL, Allen BL Jr: A biomechanical study of thoracolumbar spinal fractures with bone in the canal. Part II. The effect of flexion angulation, distraction, and shortening of the motion segment. Spine 1985; 10: 586-589.
26. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21.
27. Wenner P, O'Donovan MJ: Identification of an interneuronal population that mediates recurrent inhibition of motoneurons in the developing chick spinal cord. J Neurosci 1999; 19: 7557-7567. (Pubitemid 29404612)
28. Nihal M, Ahmad N, Mukhtar H, et al: Antiproliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implictions for the chemoprevention of melanoma. Int J Cancer 2004; 114: 513-521.
29. Chen CH,Wang SM, Yang SH, et al: Role of Thy-1 in vivo and in vitro neural development and regeneration of dorsal root ganglionic neurons. J Cell Biochem 2005; 94: 684-694.
30. Hsu JY, Xu XM: Early profiles of axonal growth and astroglial response after spinal cord hemisection and implantation of Schwann cell-seeded guidance channels in adult rats. J Neurosci Res 2005; 82: 472-483.
31. Tom VJ, Houlé JD: Intraspinal microinjection of chondroitinase ABC following injury promotes axonal regeneration out of a peripheral nerve graft bridge. Exp Neurol 2008; 211: 315-319.
32. Chen H, Kohno K, Gong Q: Conditional ablation of mature olfactory sensory neurons mediated by diphtheria toxin receptor. J Neurocytol 2005; 34: 37-47. (Pubitemid 41832729)