Cancer and aging: The molecular pathways

Urologic Oncology: Seminars and Original Investigations

Volumn 27, Issue 6, 2009, Pages 620-627

  Bassi, PierFrancesco ^a   Sacco, Emilio ^a  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Aging; Apoptosis; Cancer; Oxidative stress; Senescence; Stem cell; Telomere

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN; TELOMERASE; TUMOR SUPPRESSOR PROTEIN;

AGING; APOPTOSIS; CALORIC RESTRICTION; CARCINOGENESIS; CELL CYCLE REGULATION; CELL RENEWAL; CELL RESPIRATION; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; EPIGENETICS; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; LIFESPAN; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; STEM CELL; TELOMERE;

ADULT STEM CELLS; AGING; ANIMALS; APOPTOSIS; CELL AGING; CELL RESPIRATION; CELL TRANSFORMATION, NEOPLASTIC; DNA METHYLATION; DNA REPAIR; DNA, MITOCHONDRIAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; TELOMERE;

EID: 70350474789     PISSN: 10781439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.urolonc.2009.07.013     Document Type: Review

References (74)

1. American Cancer Society. Cancer Facts and Figures 2008 (2008), American Cancer Society, Atlanta
2. Tyner S.D., Venkatachalam S., Choi J., et al. p53 mutant mice that display early aging-associated phenotypes. Nature 415 (2002) 45-53
3. Krtolica A., Parrinello S., Lockett S., et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 98 (2001) 12072-12077
4. McMurray M.A., and Gottschling D.E. An age-induced switch to a hyper-recombinational state. Science 301 (2003) 1908-1911
5. Finkel T., and Holbrook N.J. Oxidants, oxidative stress, and the biology of aging. Nature 408 (2000) 239-247
6. Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 11 (1956) 298-300
7. Beckman K.B., and Ames B.N. The free radical theory of aging matures. Physiol Rev 78 (1998) 547-581
8. de Magalhaes J.P., and Church G.M. Cells discover fire: Employing reactive oxygen species in development and consequences for aging. Exp Gerontol 41 (2006) 1-10
9. Orr W.C., and Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263 (1994) 1128-1130
10. Orr W.C., Mockett R.J., Benes J.J., et al. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. J Biol Chem 278 (2003) 26418-26422
11. Parkes T.L., Elia A.J., Dickinson D., et al. Extension of Drosophila lifespan by overexpression of human SOD1 in motor neurons. Nat Genet 19 (1998) 171-174
12. Hari R., Burde V., and Arking R. Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster. Exp Gerontol 33 (1998) 227-237
13. Larsen P.L. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci USA 90 (1993) 8905-8909
14. Ruan H., Tang X.D., Chen M.L., et al. High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proc Natl Acad Sci USA 99 (2002) 2748-2753
15. Moskovitz J., Bar-Noy S., Williams W.M., et al. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci USA 98 (2001) 12920-12925
16. Yuan H., Kaneko T., and Matsuo M. Relevance of oxidative stress to the limited replicative capacity of cultured human diploid cells: The limit of cumulative population doublings increases under low concentrations of oxygen and decreases in response to aminotriazole. Mech Aging Dev 81 (1995) 159-168
17. Benhar M., Engelberg D., and Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep 3 (2002) 420-425
18. Jackson A.L., and Loeb L.A. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res 477 (2001) 7-21
19. Preston T.J., Muller W.J., and Singh G. Scavenging of extracellular H2O2 by catalase inhibits the proliferation of HER-2/Neu-transformed rat-1 fibroblasts through the induction of a stress response. J Biol Chem 276 (2001) 9558-9564
20. Suh Y.A., Arnold R.S., Lassegue B., et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401 (1999) 79-82
21. Irani K., Xia Y., Zweier J.L., et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275 (1997) 1649-1652
22. Tsuzuki T., Egashira A., Igarashi H., et al. Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci USA 98 (2001) 11456-11461
23. Polyak K., Waldman T., He T.C., et al. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev 10 (1996) 1945-1952
24. Barja G. Endogenous oxidative stress: Relationship to aging, longevity and caloric restriction. Aging Res Rev 1 (2002) 397-411
25. Bayne A.C., Mockett R.J., Orr W.C., et al. Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila. Biochem J 391 Pt 2 (2005) 277-284
26. Miwa S., Riyahi K., Partridge L., et al. Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann NY Acad Sci 1019 (2004) 388-391
27. Singh K.K. Mitochondria damage checkpoint, aging, and cancer. Ann NY Acad Sci 1067 (2006) 182-190
28. Loeb L.A., Wallace D.C., and Martin G.M. The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc Natl Acad Sci USA 102 (2005) 18769-18770
29. Ho Y.S., Magnenat J.L., Bronson R.T., et al. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem 272 (1997) 16644-16651
30. Schriner S.E., Ogburn C.E., Smith A.C., et al. Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei. Free Radic Biol Med 29 (2000) 664-673
31. Huang T.T., Carlson E.J., Gillespie A.M., et al. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci 55 (2000) B5-B9
32. Irmgard-Finger I. Science of cancer and aging. J Clin Oncol 25 (2007) 1844-1851
33. Blackburn E.H. Structure and function of telomeres. Nature 350 (1991) 569-573
34. Huffman K.E., Levene S.D., Tesmer V.M., et al. Telomere shortening is proportional to the size of the G-rich telomeric-3′-overhang. J Biol Chem 275 (2000) 19719-19722
35. Campisi J. Aging and cancer cell biology, 2008. Aging Cell 7 (2008) 281-284
36. von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann NY Acad Sci 908 (2000) 99-110
37. Harley C.G., Vaziri H.M.C.C., and Allsopp R.C. The telomere hypothesis of cellular aging. Exp Gerontol 27 (1992) 375-382
38. Joeng K.S., Song E.J., Lee K.J., et al. Long lifespan in worms with long telomeric DNA. Nature Genetics 36 (2004) 607-611
39. Nakagawa S., Gemmell N.J., and Burke T. Measuring vertebrate telomeres: Applications and limitations. Mol Ecol 13 (2004) 2523-2533
40. Optiz O.G. Telomeres, telomerase, and malignant transformation. Curr Mol Med 5 (2005) 219-226
41. Counter C.M., Avilion A.A., LeFeuvre C.E., et al. Telomere shortening associated with chromosome instability is arrested in immortal cells, which express telomerase activity. EMBO J 11 (1992) 1921-1929
42. Kujoth G.C., Hiona A., Pugh T.D., et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309 (2005) 481-484
43. Chondrogianni N., Stratford F.L., Trougakos I.P., et al. Central role of the proteasome in senescence and survival of human fibroblasts: Induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem 278 (2003) 28026-28037
44. Sitte N., Merker K., Von Zglinicki T., et al. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts. Part I: Effects of proliferative senescence. FASEB J 14 (2000) 2495-2502
45. Hickman E.S., Moroni M.C., and Helin K. The role of p53 and pRB in apoptosis and cancer. Curr Opin Genet Dev 12 (2002) 60-66
46. Feng Z., Hu W., Rajagopal G., et al. The tumor suppressor p53: Cancer and aging. Cell Cycle 7 (2008) 842-847
47. Lane M.A., Ingram D.K., and Roth G.S. The serious search for an anti-aging pill. Scientific Am 287 (2002) 36-41
48. Zhang Y., and Herman B. Aging and apoptosis. Mech Aging Dev 123 (2002) 245-260
49. Spindler S.R. Use of microarray biomarkers to identify longevity therapeutics. Aging Cell 5 (2006) 39-50
50. Holzenberger M. The role of insulin-like signaling in the regulation of aging. Horm Res 1 Suppl 62 (2004) 89-92
51. Levine A.J., Feng Z., Mak T.W., et al. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 20 (2006) 267-275
52. Browner W.S., Kahn A.J., Ziv E., et al. The genetics of human longevity. Am J Med 117 (2004) 851-860
53. Espejel S., Martin M., Klatt P., et al. Shorter telomeres, accelerated aging, and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep 5 5 (2004) 503-509
54. de Boer J., Andressoo J.O., de Wit J., et al. Premature aging in mice deficient in DNA repair and transcription. Science 296 (2002) 1276-1279
55. Dolle M.E., Busuttil R.A., Garcia A.M., et al. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutation Res 596 (2006) 22-35
56. Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
57. Cohen H.Y., Miller C., Bitterman K.J., et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305 (2004) 390-392
58. Futami K., Ishikawa Y., Goto M., et al. Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells. Cancer Sci 99 (2008) 843-848
59. Tollefsbol T.O., and Andrews L.G. Mechanisms for methylation-mediated gene silencing and aging. Med Hypotheses 41 (1993) 83-92
60. Burzynski S.R. Aging: Gene silencing or gene activation?. Med Hypotheses 64 (2005) 201-208
61. Baylin S.B., Herman J.G., Graff J.R., et al. Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res 72 (1998) 141-196
62. Chen R.Z., Pettersson U., Beard C., et al. DNA hypomethylation leads to elevated mutation rates. Nature 395 (1998) 89-93
63. Cahill D.P., Lengauer C., Yu J., et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392 (1998) 300-303
64. Shichiri M., Yoshinaga K., Hisatomi H., et al. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res 62 (2002) 13-17
65. Percy M.J., Myrie K.A., Neeley C.K., et al. Expression and mutational analyses of the human MAD2L1 gene in breast cancer cells. Genes Chromosomes Cancer 29 (2000) 356-362
66. Wang X., Jin D.Y., Ng R.W., et al. Significance of MAD2 expression to mitotic checkpoint controlling ovarian cancer cells. Cancer Res 62 (2002) 1662-1668
67. Baker D.J., Jeganathan K.B., Malureanu L., et al. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol 172 (2006) 529-540
68. Dai W., and Wang X. Aging in check. Sci Aging Knowledge Environ (2006) pe9
69. Roobrouck V.D., Ulloa-Montoya F., and Verfaillie C.M. Self-renewal and differentiation capacity of young and aged stem cells. Exp Cell Res 314 (2008) 1937-1944
70. Ho A.D., Wagner W., and Mahlknecht U. Stem cells and aging. The potential of stem cells to overcome age-related deteriorations of the body in regenerative medicine. EMBO reports 6 (2005) S35-S38
71. Chen J., Astle C.M., and Harrison D.E. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp Hematol 31 (2003) 1097-1103
72. Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8 (2007) 703-713
73. Weissman I. Stem cells: Unit of development, units of regeneration, and units of evolution. Cell 100 (2000) 157-168
74. Reya T., and Clevers H. Wnt signaling in stem cells and cancer. Nature 434 (2005) 843-850