Pharmacokinetic-pharmacodynamic and response sensitization modeling of the intraocular pressure-lowering effect of the EP4 agonist 5-{3-[(2S)-2-{(3R)-3- hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-1-yl]propyl} thiophene-2-carboxylate (PF-04475270)

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 2, 2009, Pages 627-635

  Luu, Kenneth T ^a   Zhang, Eric Y ^a   Prasanna, Ganesh ^a   Xiang, Cathie ^a   Anderson, Scott ^a   Fortner, Jay ^a   Vicini, Paolo ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 {3 [(2) 2 {(3) 3 HYDROXY 4 [3 (TRIFLUOROMETHYL)PHENYL]BUTYL} 5 OXOPYRROLIDIN 1 YL]PROPYL}THIOPHENE 2 CARBOXYLATE; AGENTS ACTING ON THE EYE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; AQUEOUS HUMOR; ARTICLE; CILIARY BODY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORNEA; DOG; FEMALE; INTRAOCULAR PRESSURE; IRIS; MALE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; RESPONSE TIME; SENSITIZATION; SINGLE DRUG DOSE;

ALGORITHMS; ANIMALS; AQUEOUS HUMOR; CILIARY BODY; DOGS; FEMALE; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; MALE; MODELS, STATISTICAL; OCULAR HYPERTENSION; PRODRUGS; PYRROLIDINONES; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; THIOPHENES;

EID: 70350469985     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.157800     Document Type: Article

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