Antegrade cerebral perfusion during deep hypothermia circulatory arrest attenuates the apoptosis of neurons in porcine hippocampus

Heart Surgery Forum

Volumn 12, Issue 4, 2009, Pages

  Zhao, Rong ^a   Cui, Qin ^a   Yu, Shi Qiang ^a   Sun, Guo Cheng ^a   Wang, Hong Bing ^a   Jin, Zheng Xiao ^a   Gu, Chun Hu ^a   Yi, Ding Hua ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTEGRADE CEREBRAL PERFUSION; APOPTOSIS; ARTICLE; BRAIN PERFUSION; BRAIN TISSUE; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DEEP HYPOTHERMIC CIRCULATORY ARREST; FLOW RATE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGY; NERVE CELL; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BRAIN INJURY; METABOLISM; METHODOLOGY; REPERFUSION;

ANIMALS; APOPTOSIS; BRAIN INJURIES; CIRCULATORY ARREST, DEEP HYPOTHERMIA INDUCED; HIPPOCAMPUS; MALE; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; REPERFUSION; SWINE;

EID: 70350462910     PISSN: 10983511     EISSN: 15226662     Source Type: Journal    
DOI: 10.1532/HSF98.20091018     Document Type: Article

References (25)

1. Ananiadou OG, Drossos GE, Bibou KN, Palatianos GM, Johnson EO. 2005. Acute regional neuronal injury following hypothermic circulatory arrest in a porcine model. Interact Cardiovasc Thorac Surg 4:597-601.
2. Antonawich FJ, Federoff HJ, Davis JN. 1999. BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Exp Neurol 156:130-7.
3. Bellinger DC, Jonas RA, Rappaport LA, et al. 1995. Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. N Engl J Med 332:549-55.
4. Di Eusanio M, Schepens MA, Morshuis WJ, et al. 2003. Brain protection using antegrade selective cerebral perfusion: a multicenter study. Ann Thorac Surg 76:1181-9.
5. Gibson ME, Han BH, Choi J, et al. 2001. Bax contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways. Mol Med 7:644-55.
6. Greeley WJ, Kern FH, Ungerleider RM, et al. 1991. The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children. J Thorac Cardiovasc Surg 101:783-94.
7. Gu CH, Wei XF, Wang YY, et al. 2008. No evidence of infection with porcine endogenous retrovirus in recipients of acellularized porcine aortic valves. Xenotransplantation 15:121-8.
8. Harris MH, Thompson CB. 2000. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ 7:1182-91.
9. Hata R, Gillardon F, Michaelids TM, Hossmann KA. 1999. Targeted disruption of the bcl-2 gene in mice exacerbate focal ischemic brain injury. Metab Brain Dis 14:117-24.
10. Institute of Laboratory Animal Research. 1996. Guide for the care and use of laboratory animals. Commission on Life Sciences, National Research Council. Washington, DC: National Academies Press. NIH publication 86-23.
11. Jonas RA. 1996. Hypothermia, circulatory arrest, and the pediatric brain. J Cardiothorac Vasc Anesth 10:66-74.
12. Jurgensmeier JM, Xie Z, Deveraux Q, et al. 1998. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95;4997-5002.
13. Kaneda K, Kashii S, Kurosawa T, et al. 1999. Apoptosis DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina. Brain Res 815:11-20.
14. Kazui T, Washiyama N, Muhammad B, Terada H, Yamashita K, Takinami M. 2001. Improved results of atherosclerotic arch aneurysm operations with a refined technique. J Thorac Cardiovasc Surg 121:491-9.
15. Kurth CD, Priestley M, Golden J, McCann J, Raghupathi R. 1999. Regional patterns of neuronal death after deep hypothermic circulatory arrest in newborn pigs. Thorac Cardiovasc Surg 118:1068-77.
16. Langley SM, Chai PJ, Miller SE, et al. 1999. Intermittent perfusion protects the brain during deep hypothermic circulatory arrest. Ann Thorac Surg 68:4-13.
17. Lossi L, Merighi A. 2003. In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS. Prog Neurobiol 69:287-312.
18. Mills NL, Ochsner JL. 1980. Massive air embolism during cardiopulmonary bypass. Causes, prevention, and management. J Thorac Cardiovasc Surg 80:708-17.
19. Oltvai ZN, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-19.
20. Plesnila N, Zinkel S, Amin-Hanjani S, Qin J, Korsmeyer SJ, Moskowitz MA. 2002. Function of BID-a molecule of the bcl-2 family-in ischemic cell death in the brain. Eur Surg Res 34:37-41.
21. Strauch JT, Spielvogel D, Haldenwang PL, et al. 2003. Cerebral physiology and outcome after hypothermic circulatory arrest followed by selective cerebral perfusion. Ann Thorac Surg 76:1972-81.
22. Swain JA, McDonald TJ Jr, Griffith PK, Balaban RS, Clark RE, Ceckler T. 1991. Low-flow hypothermic cardiopulmonary bypass protects the brain. J Thorac Cardiovasc Surg 102:76-84.
23. Swanton E, Savory P, Cosulich S, Clarke P, Woodman P. 1999. Bcl-2, regulates a caspase-3/caspase-2 apoptotic, cascade, in cytosolic extracts. Oncogene 18:1781-7.
24. Tseng EE, Brock MV, Lange MS. 1997. Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg 64:1639-47.
25. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. 1984. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-9.