Phospholipase PlaB of Legionella pneumophila represents a novel lipase family. Protein residues essential for lipolytic activity, substrate specificity and hemolysis

Journal of Biological Chemistry

Volumn 284, Issue 40, 2009, Pages 27185-27194

  Bender, Jennifer ^a   Rydzewski, Kerstin ^a   Broich, Markus ^a   Schunder, Eva ^a   Heuner, Klaus ^a   Flieger, Antje ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; C TERMINUS; CARBON ATOMS; CATALYTIC ACTIVITY; CATALYTIC TRIAD; CLINICAL ISOLATES; ENZYMATIC ACTIVITIES; HOST CELLS; IN-VITRO; INTRACELLULAR REPLICATION; LEGIONELLA; LEGIONELLA PNEUMOPHILA; LIPOLYTIC; LIPOLYTIC ACTIVITY; LONG-CHAIN FATTY ACIDS; N-TERMINALS; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPASE A; PHOSPHOLIPASES; PHOSPHOLIPID SUBSTRATE; PROTEIN RESIDUES; SUBSTRATE SPECIFICITY; VIRULENCE FACTORS;

AMINATION; AMINES; AMINO ACIDS; ENZYME ACTIVITY; ENZYMES; FATTY ACIDS; HYDROLYSIS; ORGANIC ACIDS; PHOSPHOLIPIDS; PLANTS (BOTANY); SUBSTRATES;

CELL MEMBRANES;

BACTERIAL ENZYME; LONG CHAIN FATTY ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPASE; PHOSPHOLIPASE PLAB; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; FATTY ACID; PHOSPHOLIPASE A;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BACTERIUM ISOLATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; EUKARYOTIC CELL; HEMOLYSIS; HYDROLYSIS; LEGIONELLA; LEGIONELLA GORMANII; LEGIONELLA PNEUMOPHILA; LEGIONELLA SPIRITENSIS; LIPOLYSIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; AMINO ACID SEQUENCE; BACTERIAL GENE; BIOCATALYSIS; CELL STRAIN U937; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LEGIONNAIRE DISEASE; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SPECIES DIFFERENCE;

BACTERIA (MICROORGANISMS); EUKARYOTA; FLUORIBACTER GORMANII; LEGIONELLA; LEGIONELLA PNEUMOPHILA; LEGIONELLA SPIRITENSIS;

AMINO ACID SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; FATTY ACIDS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HEMOLYSIS; HUMANS; HYDROLYSIS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; LIPOLYSIS; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLCHOLINES; PHOSPHOLIPASES A; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; U937 CELLS;

EID: 70350462117     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.026021     Document Type: Article

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