Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries

Acta Oto-Laryngologica

Volumn 129, Issue 10, 2009, Pages 1036-1043

  Yang, Wei Ping ^a,b   Hu, Bo Hua ^a   Chen, Guang Di ^a   Bielefeld, Eric C ^a   Henderson, Donald ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Antioxidant; Apoptosis; Cochlea; Necrosis; Rat; Styrene

Indexed keywords

ACETYLCYSTEINE; F ACTIN; PHALLOIDIN; PROPIDIUM IODIDE; STYRENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL LOSS; CELL NUCLEUS; COCHLEA; COCHLEA INJURY; CONTROLLED STUDY; EAR PROTECTION; EVOKED BRAIN STEM AUDITORY RESPONSE; HAIR CELL; HEARING LOSS; MAXIMUM ALLOWABLE CONCENTRATION; NICK END LABELING; NONHUMAN; OTOTOXICITY; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STAINING;

ACETYLCYSTEINE; ANIMALS; FREE RADICAL SCAVENGERS; GLUTATHIONE; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS; RATS; RATS, LONG-EVANS; STYRENE;

EID: 70350453774     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480802566261     Document Type: Article

References (20)

1. Miller RR, Newhook R, Poole A. Styrene production, use, and human exposure. Crit Rev Toxicol 1994;/24 Suppl:/ S1-S10.
2. Bond JA. Review of the toxicology of styrene. Crit Rev Toxicol 1989;/19:/227-49.
3. Lawton BW, Hoffmann J, Triebig G. The ototoxicity of styrene: a review of occupational investigations. Int Arch Occup Environ Health 2006;/79:/93-102.
4. Chen GD, Chi LH, Kostyniak PJ, Henderson D. Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss. Toxicol Sci 2007;/ 98:/167-77.
5. Gagnaire F, Langlais C. Relative ototoxicity of 21 aromatic solvents. Arch Toxicol 2005;/79:/346-54.
6. Lataye R, Campo P, Barthelemy C, Loquet G, Bonnet P. Cochlear pathology induced by styrene. Neurotoxicol Teratol 2001;/23:/71-9.
7. Loquet G, Campo P, Lataye R. Comparison of tolueneinduced and styrene-induced hearing losses. Neurotoxicol Teratol 1999;/21:/689-97.
8. Pouyatos B, Morel G, Lambert-Xolin AM, Maguin K, Campo P. Consequences of noise- or styrene-induced cochlear damages on glutamate decarboxylase levels in the rat inferior colliculus. Hear Res 2004;/189:/83-91.
9. Boccellino M, Cuccovillo F, Napolitano M, Sannolo N, Balestrieri C, Acampora A, et al. Styrene-7,8-oxide activates a complex apoptotic response in neuronal PC12 cell line. Carcinogenesis 2003;/24:/535-40.
10. Diodovich C, Bianchi MG, Bowe G, Acquati F, Taramelli R, Parent-Massin D, et al. Response of human cord blood cells to styrene exposure: evaluation of its effects on apoptosis and gene expression by genomic technology. Toxicology 2004;/ 200:/145-57.
11. Dare E, Tofighi R, Vettori MV, Momoi T, Poli D, Saido TC, et al. Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells. Brain Res 2002;/933:/12-22.
12. Coccini T, Fenoglio C, Nano R, De Piceis Polver P, Moscato G, Manzo L. Styrene-induced alterations in the respiratory tract of rats treated by inhalation or intraperitoneally. J Toxicol Environ Health 1997;/52:/63-77.
13. Dixit R, Das M, Mushtaq M, Srivastava SP, Seth PK. Depletion of glutathione content and inhibition of glutathione- S-transferase and aryl hydrocarbon hydroxylase activity of rat brain following exposure to styrene. Neurotoxicology 1982;/3:/142-5.
14. Coccini T, Di Nucci A, Tonini M, Maestri L, Costa LG, Liuzzi M, et al. Effects of ethanol administration on cerebral non-protein sulfhydryl content in rats exposed to styrene vapour. Toxicology 1996;/106:/115-22.
15. Costa C, Pasquale RD, Silvari V, Barbaro M, Catania S. In vitro evaluation of oxidative damage from organic solvent vapours on human skin. Toxicol In Vitro 2006;/20:/324-31.
16. Dare E, Tofighi R, Nutt L, Vettori MV, Emgard M, Mutti A, et al. Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons. Toxicology 2004;/201:/125-32. (Pubitemid 39023940)
17. Kopke RD, Weisskopf PA, Boone JL, Jackson RL, Wester DC, Hoffer ME, et al. Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla. Hear Res 2000;/149:/138-46.
18. Hu BH, Guo W, Wang PY, Henderson D, Jiang SC. Intense noise-induced apoptosis in hair cells of guinea pig cochleae. Acta Otolaryngol 2000;/120:/19-24.
19. Phelps DT, Deneke SM, Daley DL, Fanburg BL. Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine. Am J Respir Cell Mol Biol 1992;/7:/ 293-299
20. Turner M, Mantick NA, Carlson GP. Comparison of the depletion of glutathione in mouse liver and lung following administration of styrene and its metabolites styrene oxide and 4-vinylphenol. Toxicology 2005;/206:/383-8.