Enhanced gene expression and reduced toxicity in mice using polyplexes of low-molecular-weight poly(ethylene imine) for pulmonary gene delivery

Journal of Drug Targeting

Volumn 17, Issue 8, 2009, Pages 638-651

  Kleemann, Elke ^a,b   Jekel, Norman ^b   Dailey, Lea Ann ^a   Roesler, Susanne ^a,b   Fink, Ludger ^b   Weissmann, Norbert ^b   Schermuly, Ralph ^b   Gessler, Tobias ^b   Schmehl, Thomas ^b   Roberts, Clive J ^c   Seeger, Werner ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

cytotoxicity; intratracheal instillation; Low molecular weight PEI; pulmonary gene delivery; transfection efficiency

Indexed keywords

BERACTANT; BRANCHED POLY(ETHYLENE IMINE)DNA; LACTATE DEHYDROGENASE; LOW MOLECULAR WEIGHT POLY(ETHYLENE IMINE)DNA; LUCIFERASE; MACROGOL; NAKED DNA; POLYMER; UNCLASSIFIED DRUG; DNA; IMINE; MACROGOL DERIVATIVE; POLY(ETHYLENE IMINE); POLYETHYLENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS; CONTROLLED STUDY; CYTOTOXICITY; DNA TRANSFECTION; DRUG STABILITY; ESCHERICHIA COLI; GENE DELIVERY SYSTEM; GENE EXPRESSION; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO GENE TRANSFER; LUNG; LUNG ALVEOLUS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR WEIGHT;

ANIMALS; BRONCHI; DNA; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; IMINES; LUCIFERASES; LUNG; MICE; MICE, INBRED C57BL; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POLYETHYLENES; POLYMERS; TRANSFECTION;

EID: 70350452391     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860903106414     Document Type: Article

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