The course of adverse effects of nortriptyline and venlafaxine in elderly patients with major depression

Journal of the American Geriatrics Society

Volumn 57, Issue 11, 2009, Pages 2112-2117

  Kok, Rob M ^a   Aartsen, Marja ^b   Nolen, Willem A ^c   Heeren, Thea J ^d  

^a PARNASSIA PSYCHIATRIC INSTITUTE   (Netherlands)

^b Knowledge Centre of Psychiatry in the Elderly   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d Symfora Group   (Netherlands)

Author keywords

Adverse effects; Antidepressants; Elderly; Randomized controlled trial

Indexed keywords

NORTRIPTYLINE; VENLAFAXINE;

AGED; ARTICLE; CLINICAL TRIAL; COMORBIDITY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; GERIATRIC PATIENT; HOSPITAL PATIENT; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL HOSPITAL; MICTURITION; MINI MENTAL STATE EXAMINATION; MONTGOMERY ASBERG DEPRESSION RATING SCALE; NEUROLOGIC EXAMINATION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT DURATION; WEIGHT GAIN; XEROSTOMIA;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; COMORBIDITY; CROSS-SECTIONAL STUDIES; CYCLOHEXANOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HOSPITALS, PSYCHIATRIC; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; NORTRIPTYLINE; PERSONALITY ASSESSMENT; RISK FACTORS;

EID: 70350452138     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2009.02524.x     Document Type: Article

References (23)

1. Mittmann N, Herrmann N, Einarson TR et al. The efficacy, safety and tolerability of antidepressants in late life depression: A meta-analysis. J Affect Disord 1997 46 : 191 217.
2. Wilson K, Mottram P, Sivanranthan A et al. Antidepressant versus placebo for depressed elderly. Cochrane Database Syst Rev 2001 (1):CD 000561.
3. Taylor WD, Doraiswamy PM. A systematic review of antidepressant placebo-controlled trials for geriatric depression: Limitations of current data and directions for the future. Neuropsychopharmacology 2004 29 : 2285 2299.
4. Mottram P, Wilson K, Strobl J. Antidepressants for depressed elderly. Cochrane Database Syst Rev 2006 (1):CD003491.
5. Wang PS, Schneeweiss S, Brookhart MA et al. Suboptimal antidepressant use in the elderly. J Clin Psychopharmacol 2005 25 : 118 126.
6. Wilson K, Mottram P. A comparison of side effects of selective serotonin reuptake inhibitors and tricyclic antidepressants in older depressed patients: A meta-analysis. Int J Geriatr Psychiat 2004 19 : 754 762.
7. Demyttenaere K, Albert A, Mesters P et al. What happens with adverse events during 6 months of treatment with selective serotonin reuptake inhibitors? J Clin Psychiatry 2005 66 : 859 863.
8. Zajecka J, Amsterdam JD, Quitkin FM et al. Changes in adverse events reported by patients during 6 months of fluoxetine therapy. J Clin Psychiatry 1999 60 : 389 394.
9. Miller MD, Pollock BG, Rifai AH et al. Longitudinal analysis of nortriptyline side effects in elderly depressed patients. J Geriatr Psychiatry Neurol 1991 4 : 226 230.
10. Reynolds CF, Frank E, Perel JM et al. Nortriptyline side effects during double-blind- randomized, placebo-controlled maintenance therapy in older depressed patients. Am J Geriatr Psychiatry 1995 3 : 170 175.
11. Marraccini RL, Reynolds CF III., Houck PR et al. A double-blind, placebo-controlled assessment of nortriptyline's side-effects during 3-year maintenance treatment in elderly patients with recurrent major depression. Int J Geriatr Psychiatry 1999 14 : 1014 1018.
12. Kok RM, Nolen WA, Heeren TJ. Venlafaxine versus nortriptyline in the treatment of elderly depressed inpatients. A randomised, double-blind, controlled trial. Int J Geriatr Psychiatry 2007 22 : 1047 1054.
13. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979 134 : 382 389.
14. Folstein MF, Folstein SE, McHugh PR. Mini-mental state, a practical method for grading the cognitive state for the clinician. J Psychiatr Res 1975 12 : 189 198.
15. Fawcett J, Epstein P, Fiester SJ et al. Clinical management - imipramine/placebo administration manual. Psychopharmacol Bull 1987 23 : 309 324.
16. Burvill PW, Mowry B, Hall WD. Quantification of physical illness in psychiatric research in the elderly. Int J Geriatr Psychiatry 1990 5 : 161 170.
17. Willett JB, Sayer AG. Cross-domain analysis of change over time. Combining growth modeling and covariance structure analysis. In : Marcoulides GA, Schumacker RE, editors. Advanced Structural Equation Modelling; Issues and Techniques. Mahwah, NJ : Lawrence Erlbaum, 1996, pp 125 157.
18. Willett JB, Sayer AG. Using covariance structure analysis to detect correlates and predictors of individual change over time. Psychol Bulletin 1994 116 : 363 381.
19. Duncan TE, Duncan SC, Strycker LA. An Introduction to Latent Variable Growth Curve Modeling: Concepts, Issues and Applications. Mahwah, NJ : Lawrence Erlbaum, 2006.
20. Georgotas A, McCue RE, Cooper TB. A placebo-controlled comparison of nortriptyline and phenelzine in maintenance therapy of elderly depressed patients. Arch Gen Psychiatry 1989, 783 786.
21. Reynolds CF III., Frank E, Perel JM et al. Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: A randomized controlled trial in patients older than 59 years. JAMA 1999 281 : 39 45.
22. Drayer RA, Mulsant BH, Lenze EJ et al. Somatic symptoms of depression in elderly patients with medical comorbidities. Int J Geriatr Psychiatry 2005 20 : 973 982.
23. Alexopoulos GS, Katz IR, Reynolds CF et al. Pharmacotherapy of depressive disorders in older patients. Postgrad Med 2001 1 86.