Current perspectives on role of chromatin modifications and deacetylases in lung inflammation in COPD

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 6, Issue 4, 2009, Pages 291-297

  Rajendrasozhan, Saravanan ^a   Yao, Hongwei ^a   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cigarette smoke; COPD; Epigenetics; HDAC; Oxidants; SIRT1

Indexed keywords

CIGARETTE SMOKE; HISTONE DEACETYLASE 2; HISTONE H3; SIRTUIN 1; TRANSCRIPTION FACTOR RELA;

ACETYLATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPLEX FORMATION; CONFERENCE PAPER; DEACETYLATION; ENZYME ACTIVATION; ENZYME METABOLISM; EPIGENETICS; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN PROCESSING;

CHROMATIN; EPIGENESIS, GENETIC; HISTONE DEACETYLASE 2; HISTONE DEACETYLASES; HUMANS; INFLAMMATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIRTUIN 1; SMOKING;

EID: 70350433679     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.1080/15412550903049132     Document Type: Conference Paper

References (56)

1. Rahman I. Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: Cellular and molecular mechanisms. Cell Biochem Biophys 2005; 43:167-188.
2. Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J 2006; 28:219-242.
3. Gosden RG, Feinberg AP. Genetics and epigenetics-nature's pen-and-pencil set. N Engl J Med 2007; 356:731-733.
4. Li B, Carey M, Workman JL. The role of chromatin duringtranscription. Cell 2007; 128:707-719.
5. Rahman I. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J Biochem Mol Biol 2003; 36:95-109.
6. Marwick JA, Kirkham PA, Stevenson CS, Danahay H, Giddings J, Butler K, Donaldson K, Macnee W, Rahman I. Cigarette smoke alters chromatin remodeling and induces proin- flammatory genes in rat lungs. Am J Respir Cell Mol Biol 2004; 31:633-642.
7. Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I. IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am J Respir Cell Mol Biol 2008; 38:689-698.
8. Szulakowski P, Crowther AJ, Jimenez LA, Donaldson K,Mayer R, Leonard TB, MacNee W, Drost EM. The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit CareMed 2006; 174:41-50.
9. Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, Barczyk A, Hayashi S, Adcock IM, Hogg JC, Barnes PJ. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 2005; 352:1967-1976. (Pubitemid 40638367)
10. Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 177:861-870.
11. Lo WS, Trievel RC, Rojas JR, Duggan L, Hsu JY, Allis CD, Marmorstein R, Berger SL. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol Cell 2000; 5:917-926.
12. Clayton AL, Rose S, Barratt MJ,Mahadevan LC. Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J 2000; 19:3714-3726.
13. Thomson S, Mahadevan LC, Clayton AL. MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction. Semin Cell Dev Biol 1999; 10:205-214.
14. Gloire G, Horion J, El Mjiyad N, Bex F, Chariot A, Dejardin E, Piette J. Promoter-dependent effect of IKKalpha on NFkappaB/ p65 DNA binding. J Biol Chem 2007; 282:21308-21318.
15. Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB. Histone H3 phosphorylation by IKK-alpha is critical for cytokineinduced gene expression. Nature 2003; 423:655-659.
16. Di Fiore PP, Polo S, Hofmann K. When ubiquitin meets ubiquitin receptors: A signalling connection. Nat Rev Mol Cell Biol 2003; 4:491-497.
17. Vissers JH, Nicassio F, van Lohuizen M, Di Fiore PP, Citterio E. The many faces of ubiquitinated histone H2A: Insights from the DUBs. Cell Div 2008; 3:8.
18. Spange S, Wagner T, Heinzel T, Kramer OH. Acetylation of nonhistone proteins modulates cellular signalling at multiple levels. Int J Biochem Cell Biol 2009; 41:185-198.
19. Rajendrasozhan S, Yang SR, Edirisinghe I, Yao H, Adenuga D, Rahman I. Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: Epigenetics in pathogenesis of COPD. Antioxid Redox Signal 2008; 10:799-811.
20. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Histone deacetylases (HDACs): Characterization of the classical HDAC family. Biochem J 2003; 370:737-749.
21. Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 2001; 15:1110-1112.
22. Yang SR, Chida AS, Bauter MR, Shafiq N,Seweryniak K, Maggirwar SB, Kilty I, Rahman I. Cigarette smoke induces proin- flammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase inmacrophages. Am J Physiol Lung Cell Mol Physiol 2006; 291:L46-57.
23. Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol 2007; 292:L567-576.
24. Milne JC, Denu JM. The Sirtuin family: Therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 2008; 12:11-17.
25. Chen L, Fischle W, Verdin E, Greene WC. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001; 293:1653-1657.
26. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). Embo J 2003; 22:1313-1324.
27. Kamata H, Manabe T, Oka S, Kamata K, Hirata H. Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops. FEBS Lett 2002; 519:231-237.
28. Zhang J, Johnston G, Stebler B, Keller ET. Hydrogen peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing kinase. Antioxid Redox Signal 2001; 3:493-504.
29. Kefaloyianni E, Gaitanaki C, Beis I. ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cell Signal 2006; 18:2238-2251.
30. Barnes PJ. Role of HDAC2 in the pathophysiology of COPD. Annu Rev Physiol 2008; (In press).
31. Adenuga D, Yao H, March TH, Seagrave J, Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated and degraded by cigarette smoke. Am J Respir Cell Mol Biol 2008; 40:464-473.
32. Ito K, Hanazawa T, Tomita K, Barnes PJ, Adcock IM. Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: Role of tyrosine nitration. Biochem Biophys Res Commun 2004; 315:240-245.
33. Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJ. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004; 200:689-695.
34. Nott A, Watson PM, Robinson JD, Crepaldi L, Riccio A. SNitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature 2008; 455:411-415.
35. Meja KK, Rajendrasozhan S, Adenuga D, Biswas SK, Sundar IK, Spooner G, Marwick JA, Chakravarty P, Fletcher D, Whittaker P, Megson IL, Kirkham PA, Rahman I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol 2008; 39:312-323.
36. Tsai SC, Seto E. Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem 2002; 277:31826-31833.
37. Galasinski SC, Resing KA, Goodrich JA, Ahn NG. Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions. J Biol Chem 2002; 277:19618-19626.
38. Marwick JA, Stevenson CS, Barnes PJ, Ito K, Adcock IM, Kirkham PA. Cigarette smoke reduces steroid sensitivity by reducing glucocorticoid receptor (GR) and GR co-repressor expression. Am J Respir Crit Care Med 2008; 177:A333.
39. Ito K, Yamamura S, Essilfie-Quaye S, Cosio B, Ito M, Barnes PJ, Adcock IM. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med 2006; 203:7-13.
40. Liu C, Russell RM, Wang XD. Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteins. J Nutr 2004; 134:2705-2710.
41. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23:2369-2380.
42. Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 2005; 280:40364-40374.
43. Chen LF, Mu Y, Greene WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 2002; 21:6539-6548.
44. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, ChoyW, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007; 450:712-716.
45. Rajendrasozhan S, Yang SR, Caito S, Rahman I. Nucleocytoplasmic shuttling and post-translational modifications of sirtuin in response to cigarette smoke lead to increased acetylation of NF-kappaB and FOXO3. Am J Respir Crit Care Med 2008; 177: A266.
46. Caito S, Cook S, Yang SR, Rajendrasozhan S, Rahman I. Redox regulation and post-translational modification of sirtuin in response to cigarette smoke in lung epithelial cells. Am J Respir Crit Care Med 2008; 177:A348.
47. Caito S, Cook S, Yang SR, Rajendrasozhan S, Rahman I. Sirtuin 1, an oxidant sensitive deacetylase, is posttranslationally modified and degraded by proteasome in reponse to cigarette smoke in lung epithelial cells. FASEB J 2008; 22:747-1741
48. Sasaki T, Maier B, Koclega KD, Chruszcz M, Gluba W, Stukenberg PT, Minor W, Scrable H. Phosphorylation regulates SIRT1 function. PLoS ONE 2008; 3:e4020.
49. Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, Rahman I. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol 2008; 294:L1174-1186.
50. Yao H, Yang SR, Kode A, Rajendrasozhan S, Caito S, Adenuga D, Henry R, Edirisinghe I, Rahman I. Redox regulation of lung inflammation: Role of NADPH oxidase and NF-kappaB signalling. Biochem Soc Trans 2007; 35:1151-1155.
51. Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 2000; 20:6891-6903.
52. Adenuga D, March TH, Seagrave J, Rahman I. Cigarette smokeinduced loss of nuclear HDAC2 is associated with chronic inflammation and emphysema in A/J mice. Am J Respir Crit Care Med 2008; 177:A866.
53. Marwick JA, Wallis G, Meja K, Kuster B, Bouwmeester T, Chakravarty P, Fletcher D, Whittaker PA, Barnes PJ, Ito K, Adcock IM, Kirkham PA. Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun 2008; 377:797-802.
54. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001; 107:149-159.
55. Kawahara TLA, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KCL, Boxer LD, Chang HY, Chua KF. SIRT6 Links histone H3 Lysine 9 deacetylation to NF-kappaBdependent gene expression and organismal life span. Cell 2009; 136:62-74.
56. McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, Lansdorp PM, Lemieux M. Themammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 2003; 23:38-54.