Straightforward selective synthesis of linear 1-O-alkyl glycerol and di-glycerol monoethers

Tetrahedron Letters

Volumn 50, Issue 49, 2009, Pages 6891-6893

  Shi, Yan ^a,b   Dayoub, Wissam ^a   Favre Réguillon, Alain ^a,c   Chen, Guo Rong ^b   Lemaire, Marc ^a  

^a UNIVERSITÉ LYON 1   (France)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Bioinformatique et Chimie Moléculaire   (France)

Author keywords

1 O Alkyl mono and di glycerol monoethers; Di glycerol; Glycerol; Reductive alkylation

Indexed keywords

1 O ALKYL GLYCEROL; ALDEHYDE DERIVATIVE; BRONSTED ACID; DI GLYCEROL MONOETHER; ETHER DERIVATIVE; GLYCEROL DERIVATIVE; HYDROGEN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATALYST; CATCH SELECTIVITY; CHEMICAL REACTION; CHEMICAL STRUCTURE; ETHERIFICATION; MASS FRAGMENTOGRAPHY; SYNTHESIS;

EID: 70350424350     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.09.134     Document Type: Article

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24. 2 as a reducing agent: aldehyde (6 mmol) and glycerol (240 mmol) were mixed in a 100 mL steel autoclave. Pd/C (0.5 mol % Pd) and CSA (10 wt %) were added to this solution. The autoclave was first flushed with argon, then with hydrogen three times. The solution was then stirred (1500 rpm) at 140 °C under 10 bars of hydrogen for 24 h. After the reaction was complete, the solution was filtered off and extracted three times with toluene and the products were purified by silica column chromatography (eluent: cyclohexane/ethyl acetate = 4:1-1:1).