Prevalence and risk factors of radiation-induced growth hormone deficiency in childhood cancer survivors: A systematic review

Cancer Treatment Reviews

Volumn 35, Issue 7, 2009, Pages 616-632

  Mulder, Renée L ^a   Kremer, Leontien C M ^a   Santen, Hanneke M van ^a   Ket, Jan Lucas ^b   Trotsenburg, A S Paul van ^a   Koning, Caro C E ^c   Meeteren, Antoinette Y N Schouten van ^a   Caron, Huib N ^a   Neggers, Sebastian J C M M ^d   Dalen, Elvira C van ^a  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b Waterlandziekenhuis ^*  (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Childhood cancer survivors; Cranial radiotherapy; Growth hormone deficiency; Systematic review

Indexed keywords

ARGININE; GLUCAGON; INSULIN; LEVODOPA;

AGE; BRAIN TUMOR; CANCER RADIOTHERAPY; CANCER SURVIVOR; CHILDHOOD CANCER; ENDOCRINE FUNCTION TEST; EPENDYMOMA; GROWTH HORMONE DEFICIENCY; HUMAN; HYDROCEPHALUS; LEUKEMIA; LYMPHOMA; MEDULLOBLASTOMA; NASOPHARYNX CARCINOMA; NEUROBLASTOMA; OUTCOME ASSESSMENT; PREVALENCE; RADIATION DOSE; RADIATION INJURY; RETINOBLASTOMA; REVIEW; RISK ASSESSMENT; RISK FACTOR; SARCOMA; SEX DIFFERENCE; SKULL IRRADIATION; SYSTEMATIC REVIEW;

ADOLESCENT; ADULT; CHILD; HUMAN GROWTH HORMONE; HUMANS; NEOPLASMS; PREVALENCE; RADIATION INJURIES; RADIOTHERAPY; RISK FACTORS; SURVIVORS; YOUNG ADULT;

EID: 70350405324     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2009.06.004     Document Type: Review

References (55)

1. Curry H.L., Parkes S.E., Powell J.E., et al. Caring for survivors of childhood cancers: the size of the problem. Eur J Cancer 42 (2006) 501-505 508
2. Heymans H.S., and Caron H.N. Childhood cancers in the Netherlands (1989-1997). Ned Tijdschr Geneeskd 145 (2001) 1442-1444
3. Geenen M.M., Cardous-Ubbink M.C., Kremer L.C., et al. Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA 297 (2007) 2705-2715
4. Shalet S.M., Beardwell C.G., Pearson D., et al. The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol (Oxf) 5 (1976) 287-290
5. Darzy K.H., and Shalet S.M. Radiation-induced growth hormone deficiency. Horm Res 59 Suppl. 1 (2003) 1-11
6. Schmiegelow M. Endocrinological late effects following radiotherapy and chemotherapy of childhood brain tumours. Dan Med Bull 53 (2006) 326-341
7. Thomsett M.J., Conte F.A., Kaplan S.L., et al. Endocrine and neurologic outcome in childhood craniopharyngioma: review of effect of treatment in 42 patients. J Pediatr 97 (1980) 728-735
8. Stahnke N., Grubel G., Lagenstein I., et al. Long-term follow-up of children with craniopharyngioma. Eur J Pediatr 142 (1984) 179-185
9. Gleeson H.K., and Shalet S.M. Endocrine complications of neoplastic diseases in children and adolescents. Curr Opin Pediatr 13 (2001) 346-351
10. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. J Clin Endocrinol Metab 1998;83:379-81.
11. Gleeson H.K., and Shalet S.M. The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocr Relat Cancer 11 (2004) 589-602
12. Grimes D.A., and Schulz K.F. Cohort studies: marching towards outcomes. Lancet 359 (2002) 341-345
13. Laupacis A., Wells G., Richardson W.S., et al. Users' guides to the medical literature. V. How to use an article about prognosis. Evidence-Based Medicine Working Group. JAMA 272 (1994) 234-237
14. Gardner M.J., and Altman D.G. Statistics with confidence, 1st ed (1989), BMJ Publishing Group, London
15. Gandrud L.M., and Wilson D.M. Is growth hormone stimulation testing in children still appropriate?. Growth Horm IGF Res 14 (2004) 185-194
16. Shalet S.M., Beardwell C.G., Morris-Jones P.H., et al. Pituitary function after treatment of intracranial tumours in children. Lancet 2 (1975) 104-107
17. Shalet S.M., Beardwell C.G., MacFarlane I.A., et al. Endocrine morbidity in adults treated with cerebral irradiation for brain tumours during childhood. Acta Endocrinol (Copenh) 84 (1977) 673-680
18. Shalet S.M., Price D.A., Beardwell C.G., et al. Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia. J Pediatr 94 (1979) 719-722
19. Hirsch J.F., Renier D., Czernichow P., et al. Medulloblastoma in childhood. Survival and functional results. Acta Neurochir (Wien) 48 (1979) 1-15
20. Pomarede R., Czernichow P., Zucker J.M., et al. Incidence of anterior pituitary deficiency after radiotherapy at an early age: study in retinoblastoma. Acta Paediatr Scand 73 (1984) 115-119
21. Voorhess M.L., Brecher M.L., Glicksman A.S., et al. Hypothalamic-pituitary function of children with acute lymphocytic leukemia after three forms of central nervous system prophylaxis. A retrospective study. Cancer 57 (1986) 1287-1291
22. Brauner R., Prevot C., Roy M.P., et al. Growth, growth hormone secretion and somatomedin C after cranial irradiation for acute lymphoblastic leukemia. Acta Endocrinol Suppl (Copenh) 279 (1986) 178-182
23. Brauner R., Czernichow P., and Rappaport R. Greater susceptibility to hypothalamopituitary irradiation in younger children with acute lymphoblastic leukemia. J Pediatr 108 (1986) 332
24. Sanders J.E., Pritchard S., Mahoney P., et al. Growth and development following marrow transplantation for leukemia. Blood 68 (1986) 1129-1135
25. Kirk J.A., Raghupathy P., Stevens M.M., et al. Growth failure and growth-hormone deficiency after treatment for acute lymphoblastic leukaemia. Lancet 1 (1987) 190-193
26. Logghe K.A., Bourguignon J.P., Craen M., et al. Factors contributing to the impairment of growth in children with acute lymphoblastic leukemia. Horm Res 30 (1988) 62-67
27. Borgström B., and Bolme P. Growth and growth hormone in children after bone marrow transplantation. Horm Res 30 (1988) 98-100
28. Cicognani A., Cacciari E., Vecchi V., et al. Differential effects of 18- and 24-Gy cranial irradiation on growth rate and growth hormone release in children with prolonged survival after acute lymphocytic leukemia. Am J Dis Child 142 (1988) 1199-1202
29. Brauner R., Rappaport R., Prevot C., et al. A prospective study of the development of growth hormone deficiency in children given cranial irradiation, and its relation to statural growth. J Clin Endocrinol Metab 68 (1989) 346-351
30. Clayton P.E., and Shalet S.M. Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Pediatr 118 (1991) 226-228
31. Ogilvy-Stuart A.L., Clark D.J., Wallace W.H., et al. Endocrine deficit after fractionated total body irradiation. Arch Dis Child 67 (1992) 1107-1110
32. Oberfield SE, Sklar C, Allen J, et al. Thyroid and gonadal function and growth of long-term survivors of medulloblastoma/PNET. In: Green DM, D'Angio GJ, editors. Late effects of treatment for childhood cancer. New York: Wiley-Liss Inc.; 1992, p. 55-62.
33. Caruso-Nicoletti M., Mancuso M., Spadaro G., et al. Growth and growth hormone in children during and after therapy for acute lymphoblastic leukaemia. Eur J Pediatr 152 (1993) 730-733
34. Thomas B.C., Stanhope R., Plowman P.N., et al. Endocrine function following single fraction and fractionated total body irradiation for bone marrow transplantation in childhood. Acta Endocrinol (Copenh) 128 (1993) 508-512
35. Brauner R., Fontoura M., Zucker J.M., et al. Growth and growth hormone secretion after bone marrow transplantation. Arch Dis Child 68 (1993) 458-463
36. Talvensaari K.K., Lanning M., Paakko E., et al. Pituitary size assessed with magnetic resonance imaging as a measure of growth hormone secretion in long term survivors of childhood cancer. J Clin Endocrinol Metab 79 (1994) 1122-1127
37. Jereb B., Korenjak R., Krzisnik C., et al. Late sequelae in children treated for brain tumors and leukemia. Acta Oncol 33 (1994) 159-164
38. Holm K., Nysom K., Rasmussen M.H., et al. Growth, growth hormone and final height after BMT. Possible recovery of irradiation-induced growth hormone insufficiency. Bone Marrow Transplant 18 (1996) 163-170
39. Brauner R., Adan L., Souberbielle J.C., et al. Contribution of growth hormone deficiency to the growth failure that follows bone marrow transplantation. J Pediatr 130 (1997) 785-792
40. Brennan B.M., Rahim A., Mackie E.M., et al. Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood. Clin Endocrinol (Oxf) 48 (1998) 777-783
41. Melin A.E., Adan L., Leverger G., et al. Growth hormone secretion, puberty and adult height after cranial irradiation with 18 Gy for leukaemia. Eur J Pediatr 157 (1998) 703-707
42. Schmiegelow M., Lassen S., Poulsen H.S., et al. Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study. Clin Endocrinol (Oxf) 53 (2000) 191-197
43. Heikens J., Ubbink M.C., van der Pal H.P., et al. Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. Cancer 88 (2000) 2116-2121
44. Merchant T.E., Goloubeva O., Pritchard D.L., et al. Radiation dose-volume effects on growth hormone secretion. Int J Radiat Oncol Biol Phys 52 (2002) 1264-1270
45. Xu W., Janss A., and Moshang T. Adult height and adult sitting height in childhood medulloblastoma survivors. J Clin Endocrinol Metab 88 (2003) 4677-4681
46. Link K., Moëll C., Garwicz S., et al. Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood. J Clin Endocrinol Metab 89 (2004) 5003-5012
47. Gurney J.G., Ness K.K., Sibley S.D., et al. Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. Cancer 107 (2006) 1303-1312
48. Olshan J.S., Gubernick J., Packer R.J., et al. The effects of adjuvant chemotherapy on growth in children with medulloblastoma. Cancer 70 (1992) 2013-2017
49. Gleeson H.K., Gattamaneni H.R., Smethurst L., et al. Reassessment of growth hormone status is required at final height in children treated with growth hormone replacement after radiation therapy. J Clin Endocrinol Metab 89 (2004) 662-666
50. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J Clin Endocrinol Metab 2000;85:3990-3.
51. Haddy T.B., Mosher R.B., Nunez S.B., et al. Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. Pediatr Blood Cancer 46 (2006) 258-261
52. Bidlingmaier M., and Strasburger C.J. Growth hormone assays: current methodologies and their limitations. Pituitary 10 (2007) 115-119
53. Rosenfeld R.G., Albertsson-Wikland K., Cassorla F., et al. Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab 80 (1995) 1532-1540
54. Moher D., Pham B., Lawson M.L., et al. The inclusion of reports of randomised trials published in languages other than English in systematic reviews. Health Technol Assess 7 (2003) 1-90
55. Laughton S.J., Merchant T.E., Sklar C.A., et al. Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial. J Clin Oncol 26 (2008) 1112-1118