Early biophysics of the NMDA receptor channel

Journal of Physiology

Volumn 587, Issue 19, 2009, Pages 4563-4564

  Ascher, Philippe ^a   Nowak, Linda ^b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b C3 117 VMC Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; CALCIUM CHANNEL; CALCIUM ION; CATION; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINIC RECEPTOR; AMINO ACID; MAGNESIUM ION;

BINDING SITE; BIOPHYSICS; CALCIUM CURRENT; CALCIUM TRANSPORT; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR BLOCKING; AMINO ACID ANALYSIS; CALCIUM CONDUCTANCE; CHANNEL GATING; ION PERMEABILITY; ION TRANSPORT; PROTEIN ANALYSIS; WHOLE CELL;

ANIMALS; BIOPHYSICAL PHENOMENA; CALCIUM SIGNALING; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; MAGNESIUM; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 70350393196     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.178640     Document Type: Note

References (16)

1. Antonov SM, Johnson JW. Permeant ion regulation of N-methyl-D-aspartate receptor channel block by Mg2+. Proc Natl Acad Sci U S A 1999, 96:14571-14576.
2. Ascher P, Nowak L. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture. J Physiol 1988, 399:247-266.
3. Clarke RJ, Johnson JW. NMDA receptor NR2 subunit dependence of the slow component of magnesium unblock. J Neurosci 2006, 26:5825-5834.
4. Clarke RJ, Johnson JW. Voltage-dependent gating of NR1/2B NMDA receptors NR2 subunit dependence of the slow component of magnesium unblock. J Physiol 2008, 586:5727-5741.
5. Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol Rev 1999, 51:7-61.
6. Johnson JW, Ascher P. Voltage-dependent block by intracellular Mg2+ of N-methyl-D-aspartate-activated channels. Biophys J 1990, 57:1085-1090.
7. Kampa BM, Clements J, Jonas P, Stuart GJ. Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. J Physiol 2004, 556:337-345.
8. Mayer ML, Westbrook GL. The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture. J Physiol 1985, 361:65-90.
9. Mayer ML, Westbrook GL. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J Physiol 1987, 394:501-527.
10. Mayer ML, Westbrook GL, Guthrie PB. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 1984, 309:261-263.
11. Neher E, Steinbach JH. Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol 1978, 277:153-176.
12. Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 1984, 307:462-465.
13. Schneggenburger R. Simultaneous measurement of Ca2+ influx and reversal potentials in recombinant N-methyl-D-aspartate receptor channels. Biophys J 1996, 70:2165-2174.
14. Spruston N, Jonas P, Sakmann B. Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J Physiol 1995, 482:325-352.
15. Vargas-Caballero M, Robinson HP. Fast and slow voltage-dependent dynamics of magnesium block in the NMDA receptor: the asymmetric trapping block model. J Neurosci 2004, 24:6171-6180.
16. Watanabe J, Beck C, Kuner T, Premkumar LS, Wollmuth LP. DRPEER: a motif in the extracellular vestibule conferring high Ca2+ flux rates in NMDA receptor channels. J Neurosci 2002, 22:10209-10216.