The β-lactam-sensitive d,d-carboxypeptidase activity of Pbp4 controls the l,d and d,d transpeptidation pathways in Corynebacterium jeikeium

Molecular Microbiology

Volumn 74, Issue 3, 2009, Pages 650-661

  Lavollay, Marie ^a,b,c   Arthur, Michel ^a,b,c   Fourgeaud, Martine ^a,b,c   Dubost, Lionel ^d,e   Marie, Arul ^d,e   Riegel, Philippe ^f   Gutmann, Laurent ^a,b,c,g   Mainardi, Jean Luc ^a,b,c,g  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

^d MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^e CNRS   (France)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CARBOXYPEPTIDASE; GAMMA GLUTAMYLTRANSFERASE; LEVO DEXTRO TRANSPEPTIDASE; PENICILLIN BINDING PROTEIN; PEPTIDOGLYCAN; PROTEIN PBP2C; PROTEIN PBP4; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; CORYNEBACTERIUM; CORYNEBACTERIUM JEIKEIUM; CROSS LINKING; ENZYME ACTIVITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMPICILLIN; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; CARBOXYPEPTIDASES; CATALYTIC DOMAIN; CELL WALL; CORYNEBACTERIUM; ESCHERICHIA COLI; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; OLIGOPEPTIDES; PENICILLIN-BINDING PROTEINS; PEPTIDOGLYCAN; PEPTIDYL TRANSFERASES; PROTEINS; SUBSTRATE SPECIFICITY; VANCOMYCIN RESISTANCE;

CORYNEBACTERIUM JEIKEIUM;

EID: 70350381779     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2009.06887.x     Document Type: Article

References (36)

1. Arbeloa, A., Hugonnet, J.E., Sentilhes, A.C., Josseaume, N., Dubost, L., Monsempes, C., et al. (2004) Synthesis of mosaic peptidoglycan cross-bridges by hybrid peptidoglycan assembly pathways in gram-positive bacteria. J Biol Chem 279 : 41546 41556.
2. Arthur, M., Depardieu, F., Cabanie, L., Reynolds, P. Courvalin, P. (1998) Requirement of the VanY and VanX d,d-peptidases for glycopeptide resistance in enterococci. Mol Microbiol 30 : 819 830.
3. Auger, G., van Heijenoort, J., Mengin-Lecreulx, D. Blanot, D. (2003) A MurG assay which utilises a synthetic analogue of lipid I. FEMS Microbiol Lett 219 : 115 119.
4. Betts, J.C., Lukey, P.T., Robb, L.C., McAdam, R.A. Duncan, K. (2002) Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol 43 : 717 731.
5. Biarrotte-Sorin, S., Hugonnet, J.E., Delfosse, V., Mainardi, J.L., Gutmann, L., Arthur, M. Mayer, C. (2006) Crystal structure of a novel beta-lactam-insensitive peptidoglycan transpeptidase. J Mol Biol 359 : 533 538.
6. Cremniter, J., Mainardi, J.L., Josseaume, N., Quincampoix, J.C., Dubost, L., Hugonnet, J.E., et al. (2006) Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium. J Biol Chem 281 : 32254 32262.
7. Funke, G., von Graevenitz, A., Clarridge, J.E., 3rd Bernard, K.A. (1997) Clinical microbiology of coryneform bacteria. Clin Microbiol Rev 10 : 125 159.
8. Ghuysen, J.M., Leyh-Bouille, M., Campbell, J.N., Moreno, R., Frere, J.M., Duez, C., et al. (1973) Structure of the wall peptidoglycan of Streptomyces R39 and the specificity profile of its exocellular DD-carboxypeptidase - transpeptidase for peptide acceptors. Biochemistry 12 : 1243 1251.
9. Hammes, W.P. (1976) Biosynthesis of peptidoglycan in Gaffkya homari. The mode of action of penicillin G and mecillinam. Eur J Biochem 70 : 107 113.
10. Hammes, W.P. Seidel, H. (1978a) The LD-carboxypeptidase activity in Gaffkya homari. The target of the action of certain beta-lactam antibiotics on the formation of wall-bound peptidoglycan. Eur J Biochem 91 : 509 515.
11. Hammes, W.P. Seidel, H. (1978b) The activities in vitro of DD-carboxypeptidase and LD-carboxypeptidase of Gaffkya homari during biosynthesis of peptidoglycan. Eur J Biochem 84 : 141 147.
12. Hampshire, T., Soneji, S., Bacon, J., James, B.W., Hinds, J., Laing, K., et al. (2004) Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms? Tuberculosis (Edinb) 84 : 228 238.
13. Hermann, T. (2003) Industrial production of amino acids by coryneform bacteria. J Biotechnol 104 : 155 172.
14. Hugonnet, J.E., Tremblay, L.W., Boshoff, H.I., Barry, C.E., 3rd Blanchard, J.S. (2009) Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science 323 : 1215 1218.
15. Jackman, P.J.H., Pitcher, D.G., Pelczynska, S. Borman, P. (1987) Classification of corynebacteria associated with endocarditis (group JK) as Corynebacterium jeikeium sp. nov. Syst Appl Microbiol 9 : 83 90.
16. Johnson, W.D. Kaye, D. (1970) Serious infections caused by diphtheroids. Ann N Y Acad Sci 174 : 568 576.
17. Lavollay, M., Arthur, M., Fourgeaud, M., Dubost, L., Marie, A., Veziris, N., et al. (2008) The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by l,d-transpeptidation. J Bacteriol 190 : 4360 4366.
18. Mainardi, J.L., Legrand, R., Arthur, M., Schoot, B., van Heijenoort, J. Gutmann, L. (2000) Novel mechanism of beta-lactam resistance due to bypass of DD-transpeptidation in Enterococcus faecium. J Biol Chem 275 : 16490 16496.
19. Mainardi, J.L., Morel, V., Fourgeaud, M., Cremniter, J., Blanot, D., Legrand, R., et al. (2002) Balance between two transpeptidation mechanisms determines the expression of beta-lactam resistance in Enterococcus faecium. J Biol Chem 277 : 35801 35807.
20. Mainardi, J.L., Fourgeaud, M., Hugonnet, J.E., Dubost, L., Brouard, J.P., Ouazzani, J., et al. (2005) A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway. J Biol Chem 280 : 38146 38152.
21. Mainardi, J.L., Villet, R., Bugg, T.D., Mayer, C. Arthur, M. (2008) Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria. FEMS Microbiol Rev 32 : 386 408.
22. Park, J.T. (1952) Uridine-5′-pyrophosphate derivatives. II. Isolation from Staphylococcus aureus. J Biol Chem 194 : 877 884.
23. Riegel, P., de Briel, D., Prevost, G., Jehl, F. Monteil, H. (1994) Genomic diversity among Corynebacterium jeikeium strains and comparison with biochemical characteristics and antimicrobial susceptibilities. J Clin Microbiol 32 : 1860 1865.
24. Riegel, P., Ruimy, R., Christen, R. Monteil, H. (1996) Species identities and antimicrobial susceptibilities of corynebacteria isolated from various clinical sources. Eur J Clin Microbiol Infect Dis 15 : 657 662.
25. Riley, P.S., Hollis, D.G., Utter, G.B., Weaver, R.E. Baker, C.N. (1979) Characterization and identification of 95 diphtheroid (group JK) cultures isolated from clinical specimens. J Clin Microbiol 9 : 418 424.
26. Sauvage, E., Kerff, F., Terrak, M., Ayala, J.A. Charlier, P. (2008) The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol Rev 32 : 234 258.
27. Sifaoui, F., Arthur, M., Rice, L. Gutmann, L. (2001) Role of penicillin-binding protein 5 in expression of ampicillin resistance and peptidoglycan structure in Enterococcus faecium. Antimicrob Agents Chemother 45 : 2594 2597.
28. Sinha, R.K. Neuhaus, F.C. (1991) Biosynthesis of peptidoglycan in Gaffkya homari: on the target (s) of benzylpenicillin. Antimicrob Agents Chemother 35 : 1753 1759.
29. Skogen, V., Cherkasova, V.V., Maksimova, N., Marston, C.K., Sjursen, H., Reeves, M.W., et al. (2002) Molecular characterization of Corynebacterium diphtheriae isolates, Russia, 1957-1987. Emerg Infect Dis 8 : 516 518.
30. Soriano, F. Tauch, A. (2008) Microbiological and clinical features of Corynebacterium urealyticum: urinary tract stones and genomics as the Rosetta Stone. Clin Microbiol Infect 14 : 632 643.
31. Soriano, F., Ponte, C., Santamaria, M., Aguado, J.M., Wilhelmi, I., Vela, R. Delatte, L.C. (1985) Corynebacterium group D2 as a cause of alkaline-encrusted cystitis: report of four cases and characterization of the organisms. J Clin Microbiol 21 : 788 792.
32. Soriano, F., Zapardiel, J. Nieto, E. (1995) Antimicrobial susceptibilities of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents. Antimicrob Agents Chemother 39 : 208 214.
33. Tauch, A., Kaiser, O., Hain, T., Goesmann, A., Weisshaar, B., Albersmeier, A., et al. (2005) Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. J Bacteriol 187 : 4671 4682.
34. Tipper, D.J. Strominger, J.L. (1965) Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proc Natl Acad Sci USA 54 : 1133 1141.
35. Wichmann, S., Wirsing von Koenig, C.H., Becker-Boost, E. Finger, H. (1985) Group JK corynebacteria in skin flora of healthy persons and patients. Eur J Clin Microbiol 4 : 502 504.
36. Zapun, A., Contreras-Martel, C. Vernet, T. (2008) Penicillin-binding proteins and beta-lactam resistance. FEMS Microbiol Rev 32 : 361 385.