Glucocorticoids enhance regeneration of murine olfactory epithelium

Acta Oto-Laryngologica

Volumn 129, Issue 9, 2009, Pages 1002-1009

  Takanosawa, Minako ^a   Nishino, Hiroshi ^a   Ohta, Yasushi ^a   Ichimura, Keiichi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Glucocorticoid receptor; Glucocorticoids; Olfactory receptor neuron; Regeneration

Indexed keywords

BIOTIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PARAFFIN; TRIAMCINOLONE ACETONIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG MEGADOSE; EPITHELIUM CELL; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MOUSE; NERVE REGENERATION; NEWBORN; NICK END LABELING; NONHUMAN; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMELLING;

ANIMALS; APOPTOSIS; CELLS, CULTURED; FEMALE; GLUCOCORTICOIDS; MICE; MICE, INBRED ICR; OLFACTORY RECEPTOR NEURONS; PREGNANCY; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, GLUCOCORTICOID; REGENERATION; TRIAMCINOLONE ACETONIDE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70350366887     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480802530663     Document Type: Article

References (13)

1. Heilmann S, Huettenbrink K, Hummel T. Local and systemic administration of corticosteroids in the treatment of olfactory loss. Am J Rhinol 2004;/18:/29-33.
2. Takanosawa M, Nishino H, Ohta Y, Ichimura K. Long-term administration of glucocorticoids induced the proliferative effect on murine olfactory epithelium. Jpn J Rhinol 2004;/43:/ 361.
3. Dorscheid DR, Patchell BJ, Estrada O, Marroquin B, Tse R, White SR. Effect of corticosteroid-induced apoptosis on airway epithelial wound closure in vitro. Am J Physiol Lung Cell Mol Physiol 2006;/291:/L794-L801.
4. Sionov RV, Kfir S, Zafrir E, Cohen O, Zilberman Y, Yefenof E. Glucocorticoid-induced apoptosis revisited. A novel role for glucocorticoid receptor translocation to the mitochondria. Cell Cycle 2006;/10:/1017-1026.
5. Pujols L, Mullol J, Torrego A, Picado C. Glucocorticoid receptor in human airways. Allergy 2004;/59:/1042-1052.
6. +ATPase mRNA expression in rat olfactory mucosa during regeneration: a possible mechanism for recovery from olfactory disturbance. Chem Senses 2002;/227:/13-21.
7. Robinson AM, Kern RC, Foster JD, Fong KJ, Pitovski DZ. Expression of glucocorticoid receptor mRNA and protein in the olfactory mucosa. Physiologic and pathophysiologic implications. Laryngoscope 1998;/108:/1238-1242.
8. Cowan CM, Roskams AJ. Apoptosis in the mature and developing olfactory neuroepithelium. Microsc Res Tech 2002;/58:/204-215.
9. Sionov RV, Cohen O, Kfir S, Zilberman Y, Yefenof E. Role of mitochondrial glucocorticoid receptor in glucocorticoidinduced apoptosis. J Exp Med 2006;/203:/189-201.
10. Pujols L, Mullol J, Perez M, Roca-Ferrer J, Juan M, Xaubet A, et al. Expression of the human glucocorticoid receptor a and ß isoforms in human respiratory epithelial cells and their regulation by dexamethasone. Am J Respir Cell Moll Biol 2004;/59:/1042-1052.
11. Sousa AR, Lane SJ, Cidlowski JA, Staynov DZ, Lee TH. Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor ß-isoform. J Allergy Clin Immunol 2000;/105:/943-950.
12. Chonghaile TN, Concannon CG, Szegezdi E, Gorman AM, Samali A. Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL. Apoptosis 2006;/11:/1247-1255.
13. Madsen-Bouterse SA, Guilherme JMR, Burton JL. Glucocorticoid modulation of Bcl-2 family members A1 and Bak during delayed spontaneous apoptosis of bovine blood neutrophils. Endocrinology 2006;/147:/3826-3834.