Cytogenetic damage analysed by the dicentric assay

Annali dell'Istituto Superiore di Sanita

Volumn 45, Issue 3, 2009, Pages 251-259

  Romm, Horst ^a   Oestreicher, Ursula ^a   Kulka, Ulrike ^a  

^a BUNDESAMT FÜR STRAHLENSCHUTZ   (Germany)

Author keywords

Biological assay; Chromosome aberrations; Cytogenetic analysis; Mass casualty incidents; Radiation dose response relationship

Indexed keywords

ARTICLE; BLOOD CELL; CHROMOSOME; CHROMOSOME ABERRATION; HUMAN; METHODOLOGY; NUCLEAR ACCIDENT; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOMETRY; ULTRASTRUCTURE;

BLOOD CELLS; CHROMOSOME ABERRATIONS; CHROMOSOMES; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; RADIOACTIVE HAZARD RELEASE; RADIOMETRY;

EID: 70350346040     PISSN: 00212571     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Bender MA, Gooch PC. Types and rates of X-ray-induced chromosome aberrations in human blood irradiated in vitro. Proc Natl Acad Sci (USA) 1962;48:522-32.
2. Perry P, Wolff S. New Giemsa Method for differential staining of sister chromatids. Nature (London) 1974;251:156-8.
3. Pinkel D, Straume T, Gray JW. Cytogenetic analysis using quantitative high-sensitivity fluorescence hybridisation. Proc Natl Acad Sci USA 1986;83:2934-8.
4. Blakely WF, Salter CA, Prasanna PG. Early-response biological dosimetry-recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys 2005;89(5):494-504.
5. Voisin P, Roy L, Benderitter M. Why can't we find a better biological indicator of dose? Radiat Prot Dosimetry 2004;112(4):465-9.
6. Lloyd DC, Edwards AA, Moquet JE, Guerrero-Carbajal YC. The role of cytogenetics in early triage of radiation casualties. Appl Radiat Isotop 2000;52(5):1107-12.
7. International Atomic Energy Agency (IAEA). Cytogenetic analysis for radiation dose assessment. Vienna: IAEA; 2001. (Technical Report Series No. 405).
8. Stephan G, Pressl S. Chromosomal aberrations in peripheral lymphocytes from healthy subjects as detected in first cell division. Mutat Res 1999;446:231-7.
9. Wilkins RC, Romm H, Kao TC, Awa AA, Yoshida MA, Livingston GK, Jenkins MS, Oestreicher U, Pellmar TC, Prasanna PG. Interlaboratory comparison of the dicentric chromosome assay for radiation biodosimetry in mass casualty events. Radiat Res 2008;169(5):551-60.
10. Schmid E, Wagner FM, Romm H, Walsh L, Roos H. Doseresponse relationship of dicentric chromosomes in human lymphocytes obtained for the fission neutron therapy facility MEDAPP at the research reactor FRM II. Radiat Environ Biophys 2009;48(1):67-75.
11. Lloyd DC, Purrot RJ, Reeder EJ. The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed people. Mutat Res 1980;72:523-32.
12. Bauchinger M. Quantification of low-level radiation exposure by conventional chromosome aberration analysis. Mutat Res 1995;339:177-89.
13. Sevankaev AV, Kozlov VM, Guseev GG, Izmailova NN (Ed.). Frequency of spontaneous chromosome aberrations in the culture of human lymphocytes. Genetics (USSR) 1974;10:114-20.
14. Ganguly BB. Cell division, chromosomal damage and micronucleus formation in peripheral lymphocytes of healthy donors related to donor's age. Mutat Res 1993;295:135-48.
15. Stephan G, Pressl S. Chromosomal aberrations in peripheral lymphocytes from healthy subjects as detected in first cell division. Mutat Res 1999;446:231-7.
16. Stephan G, Schneider K, Panzer W, Walsh L, Oestreicher U. Enhanced yield of chromosome aberrations after CT examinations in paediatric patients. Int J Radiat Biol 2007;83:281-7.
17. Padovani L, Caporossi D, Tedeschi B, Vernole P, Nicoletti B, Mauro F. Cytogenetic study in lymphocytes from children exposed to ionising radiation after the Chernobyl accident. Mutat Res 1993;319:55-60.
18. Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen LE, Norppa H, Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health. Cancer Res 1998;58:4117-21.
19. Rossi AM, Hansteen IL, Skjelbred CF, Ballardin M, Maggini V, Murgia E, Tomei A, Viarengo P, Knudsen LE, Barale R, Norppa H, Bonassi S. Association between frequency of chromosomal aberrations and cancer risk is not influenced by genetic polymorphisms in GSTM1 and GSTT1. Environ Health Perspect 2009;117(2):203-8.
20. Krumrey M, Ulm G, Schmid E. Dicentric chromosomes in monolayers of human lymphocytes produced by monochromatized synchroton radiation with photon energies from 1.83 keV to 17.4 keV. Radiat Environ Biophys 2004;43:1-6.
21. Nolte R, Mühlbradt KH, Meulders JP, Stephan G, Haney M, Schmid E. RBE of quasi-monoenergetic 60 MeV neutron radiation for induction of dicentric chromosomes in human lymphocytes. Radiat Environ Biophys 2005;44:210-09.
22. Sasaki MS. Advances in the biophysical and molecular bases of radiation cytogenetics. Int J Radiat Biol 2009;85(1):26-47.
23. Tanaka K, Gajendran N and Kamada N. Relative biological effectiveness (RBE) and dose rate dependent ratio of translocation to dicentric chromosome yield in 252Cf neutrons. Indian J Sci Technol 2009;2:1-11.
24. Schmid E, Roos H, Kramer HM. The depth-dependence of the biological effectiveness of 60Co gamma rays in a large absorber determined by dicentric chromosomes in human lymphocytes. Radiat Protec Dosim 2008;130 (4):442-6.
25. Buckton KE, Langlands AO, Smith PG, Looby PC, Woodcock GE, Mc Lelland J. Chromosome aberrations induced in human peripheral blood by 2 MeV x irradiation to the whole body and in vitro. In: Proceedings of IAEA Symposium on Radiation Induced Cancer. Athens: IAEA; 1969. p.135-46.
26. Leonard A, Baltus I, Leonard ED, Gerber GB, Richard F, Wambersie A. Dose-effect relationship for in vivo and in vitro induction of dicentric aberrations in blood lymphocytes of children. Radiat Res 1995;141:95-8.
27. Schmid E, Bauchinger M, Bunde E, Ferbert HF, v. Lieven H. Comparison of the chromosome damage and its dose response after medical whole-body exposure to 60Co-gammarays and irradiation of blood in vitro. Int J Radiat Biol Relat Stud Phys Chem Med 1974;26:31-7.
28. Stephan G, Kampen WU, Nosske D, Roos H. Chromosomal aberrations in peripheral lymphocytes of patients treated with radium-224 for ankylosing spondylitis. Radiat Environ Biophys 2005;44:23-8.
29. Edwards AA, Purrott RJ, Prosser JS, Lloyd DC. The induction of chromosome aberrations in human lymphocytes by alpha-radiation. Int J Radiat Biol 1980;38:83-91.
30. Schmid E, Hieber L, Heinzmann U, Roos H, Kellerer AM. Analysis of chromosome aberrations in human peripheral lymphocytes induced by in vitro alpha-particle irradiation. Radiat Environ Biophys 1996;35:179-84.
31. Ramalho AT, Nascimento AC. The fate of chromosomal aberrations in 137Cs-exposed individuals in the Goiânia radiation accident. Health Phys 1991;60(1):67-70.
32. Oestreicher U, Braselmann H, Stephan G. Cytogenetic analyses in peripheral lymphocytes of persons living in houses with increased levels of indoor radon concentration. Cytogenet Genome Res 2004;104:232-6.
33. Dolphin, G.W. Biological dosimetry with particular reference to chromosome aberration analysis A review of methods, in Handling of rad. accidents Proc. Int. Symp. Vienna, 1969. 1969, IAEA: Vienna. p. 215-24.
34. Sasaki MS and Miyata H. Biological dosimetry in atomic bomb survivors. Nature 1968;220:1189-93.
35. Stephan, G. Chromosome aberration analysis as a dose-assessment method. Adv Radiation Biol & Peace 1999;(Suppl. 2):131-45.
36. Stephan G. Automatische Analyse dizentrische Chromosomen. In: D. Arndt and G. Obe (Ed.) Qualiẗtssicherung in der Zyto- und Molekulargenetik. RKI Schriften 1/1996, MMV Verlag München, 1996. p. 73-80.
37. Wojcik A, Gregoire E, Hayata I, Roy L, Sommer S, Stephan G, Voisin P. Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents. Cytogenet Genome Res 2004;104(1-4):200-5.
38. Deperas J, Szluinska M, Deperas-Kaminska M, Edwards A, Lloyd D, Lindholm C, Romm H, Roy L, Moss R, Morand J, Wojcik A. CABAS: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry. Radiat Prot Dosimetry 2007;124(2):115-23.
39. Piatkin EK, Nugis VIu, Chirkov AA. Estimation of absorbed dose based on the results of cytogenetic studies of lymphocyte cultures from subjects exposed in the accident at the Chernobyl Atomic Power Station. Med Radiol 1989;34:52-7.
40. Ramalho AT, Nascimento AC. The fate of chromosomal aberrations in 137Cs-exposed individuals in the Goiânia radiation accident. Health Phys 1991;60:67-70.
41. Coleman CN, Hrdina C, Bader JL, Norwood A, Hayhurst R, Forsha J, Yeskey K, Knebel A. Medical response to a radiologic/nuclear event: integrated plan from the Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services. Ann Emerg Med 2009;53(2):223-5.
42. Alexander GA, Swartz HM, Amundson SA, Blakely WF, Buddemeier B, Gallez B, Dainiak N, Goans RE, Hayes RB, Lowry PC, Noska MA, Okunieff P, Salner AL, Schauer DA, Trompier F, Turteltaub KW, Voisin P, Wiley AL Jr, Wilkins R. BiodosEPR-2006 Meeting: Acute dosimetry consensus committee recommendations on biodosimetry applications in events involving uses of radiation by terrorists and radiation accidents. Radiat Meas 2007;42:972-96.
43. Prasanna PGS, Martin PR, Subramanian U, Berdycheviski R, Krasnopolsky K, Duffy KL, Manglapus GL, Landauer MR, Srinivasan V, Boreham D, Hagan MP, Jinaratana V, Blakely WF. Cytogenetic Biodosimetry for Radiation Disasters. Recent Advances NATO RTG-099 2005. p. 10-1-14.
44. Triage, Monitoring Treatment, Handbook for Managing of the public in the event of malevolent use of radiation. Available from: www.tmthandbook.org.
45. ISO/DIS 21243 Radiation protection. Performance criteria for laboratories performing cytogenetic triage for assessment of mass casualties in radiological or nuclear emergencies. General principles and application to dicentric assay. Geneva: ISO; 2008.
46. Romm H, Kulka U, Oestreicher U. Establishing of Biodosimetry-Networks to be prepared in case of a large scale radiation accident. In: Bayer A, Kirchinger W, Reiners Chr, Schneider R (Ed.). Fragen des radiologischen und nuklearen Notfallschutzes aus medizinischer Sicht. Würzburg: Fachverband für Strahlenschutz e.V.; 2008. p. 197-204.
47. Yoshida MA, Hayata I, Tateno H, Tanaka K, Sonta S, Kodama S, Kodama Y, Sasaki MS. The Chromosome Network for Biodosimetry in Japan. Radiat Meas 2007;42:1125-27.
48. Miller SM, Ferrarotto CL, Vlahovich S, Wilkins RC, Boreham DR, Dolling JA. Canadian Cytogenetic Emergency Network (CEN) for biological dosimetry following radiological/nuclear accidents. Int J Radiat Biol 2007;83:471-7.
49. Wilkinson DT, Segura T, Prud'homme-Lalonde L, Mullins D, Lachapelle S, Qutob S, Thorleifson E, Wilkins R, Morrison D, Boreham D. Canadian biodosimetry capacity for response to radiation emergencies. Radiat Meas 2007;42:1128-32.
50. Buglova E, Roy L. Presentation of some activities of IAEA in the field of emergency preparedness. In: Proceedings of BioDose 2008. Hanover, NH.
51. Blakely WF, Carr Z, Chu MCM, Dayal-Drager R, Fujimoto K, Hopmeir M, Kulka U, Lillis-Hearne P, Livingston GK, Lloyd DC, Maznyk N, Del Rosario Perez M, Romm H, Takashima Y, Voisin P, Wilkins RC, Yoshida MA. WHO 1st Consultation on the development of a global biodosimetry laboratories network for radiation emergencies (BioDoseNet). Radiat Res 2009;171:127-39.
52. World Health Organization. WHO BioDoseNet. Geneva: WHO. Available from: www.who.int/ionizing radiation/a e/ biodosenet/en/index.html. 53.
53. World Health Organization. International Health Regulations 2005. Geneva: WHO; 2008.
54. ISO/DIS 19238. Radiation protection-performance criteria for service laboratories performing biological dosimetry by cytogenetics. Geneva: International Organization for Standardization; 2004.
55. Martin PR, Berdychevski RE, Subramanian U, Blakely WF, Prasanna PG. Sample tracking in an automated cytogenetic biodosimetry laboratory for radiation mass casualties. Radiat Meas 2007;42(6-7):1119-24.