Death and proliferation time course of stem cells transplanted in the myocardium

Molecular Imaging and Biology

Volumn 11, Issue 6, 2009, Pages 408-414

  Qiao, Hui ^a   Surti, Suleman ^a   Choi, Seok Rye ^a   Raju, Karthik ^a   Zhang, Hualei ^a,b   Ponde, Datta E ^a   Kung, Hank F ^a   Karp, Joel ^a   Zhou, Rong ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Embryonic stem cells; HSV1 tk; PET; Reporter gene; RT PCR; Sry gene

Indexed keywords

9 [4 HYDROXY 2 (HYDROXYMETHYL)BUTYL]GUANINE; FLUORODEOXYGLUCOSE F 18; HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE; ONCOLYTIC VIRUS; TESTIS DETERMINING FACTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; FEMALE; HEART MUSCLE; HERPES SIMPLEX VIRUS 1; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; STEM CELL TRANSPLANTATION;

ANIMALS; APOPTOSIS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; EMBRYONIC STEM CELLS; FEMALE; FLUORODEOXYGLUCOSE F18; GENES, REPORTER; HERPESVIRUS 1, HUMAN; IN SITU NICK-END LABELING; KINETICS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; MICE, NUDE; MUTATION; MYOCARDIUM; PHANTOMS, IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMIDINE KINASE; TRANSFECTION;

HUMAN HERPESVIRUS 1; MURINAE; RATTUS;

EID: 70350294615     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-009-0222-3     Document Type: Article

References (19)

1. Zhou R, Acton PD, Ferrari VA (2006) Imaging stem cells implanted in infarcted myocardium. J Am Coll Cardiol 48:2094-2106
2. Acton PD, Zhou R (2005) Imaging reporter genes for cell tracking with PET and SPECT. Q J Nucl Med Mol Imaging 49:349-360
3. Cao F, Lin S, Xie X et al (2006) In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 113:1005-1014
4. Wu JC, Chen IY, Sundaresan G et al (2003) Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation 108:1302-1305
5. Miyagawa M, Anton M, Haubner R et al (2004) PET of cardiac transgene expression: Comparison of 2 approaches based on herpesviral thymidine kinase reporter gene. J Nucl Med 45:1917-1923
6. Miyagawa M, Beyer M, Wagner B et al (2005) Cardiac reporter gene imaging using the human sodium/iodide symporter gene. Cardiovasc Res 65:195-202
7. Qiao H, Zhang H, Zheng Y et al (2009) Embryonic stem cell grafting in normal and infarcted myocardium: Serial assessment with MR imaging and PET dual detection. Radiology 250:821-829
8. Muller-Ehmsen J, Whittaker P, Kloner RA et al (2002) Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol 34:107-116
9. Sheikh AY, Lin SA, Cao F et al (2007) Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium. Stem Cells 25:2677-2684
10. Zhang M, Methot D, Poppa V, Fujio Y, Walsh K, Murry CE (2001) Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies. J Mol Cell Cardiol 33:907-921
11. Surti S, Karp JS, Perkins AE, Freifelder R, Muehllehner G (2003) Design evaluation of A-PET: A high sensitivity animal PET camera. IEEE Trans Nucl Sci 50:1357-1363
12. Surti S, Karp JS, Perkins AE et al (2005) Imaging performance of A-PET: a small animal PET camera. IEEE Trans Med Imag 24:844-852
13. Daube-Witherspoon ME, Matej S, Karp JS, Lewitt RM (2001) Application of the row action maximum likelihood algorithm with spherical basis functions to clinical PET imaging. IEEE Trans Nucl Sci 48:24-30
14. Ponde DE, Dence CS, Schuster DP, Welch MJ (2004) Rapid and reproducible radiosynthesis of [18F] FHBG. Nucl Med Biol 31:133-138
15. Skuk D, Caron NJ, Goulet M, Roy B, Tremblay JP (2003) Resetting the problem of cell death following muscle-derived cell transplantation: detection, dynamics and mechanisms. J Neuropathol Exp Neurol 62:951-967
16. Adonai N, Nguyen KN, Walsh J et al (2002) Ex vivo cell labeling with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography. Proc Natl Acad Sci U S A 99:3030-3035
17. Van't Hof W, Mal N, Huang Y et al (2007) Direct delivery of syngeneic and allogeneic large-scale expanded multipotent adult progenitor cells improves cardiac function after myocardial infarct. Cytotherapy 9:477-487
18. Auricchio A, Zhou R, Wilson JM, Glickson JD (2001) In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene. Proc Natl Acad Sci U S A 98:5205-5210
19. Green LA, Nguyen K, Berenji B et al (2004) A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET. J Nucl Med 45:1560-1570