Possible olanzapine-induced hepatotoxicity in a young Chinese patient

Hong Kong Medical Journal

Volumn 15, Issue 5, 2009, Pages 394-396

  Lui, S Y ^a   Tso, Steve ^a   Lam, M ^a   Cheung, Eric F C ^a  

^a CASTLE PEAK HOSPITAL   (Hong Kong)

Author keywords

Antipsychotic agents; Hepatitis, toxic; Jaundice; Schizophrenia; Splenomegaly

Indexed keywords

AMISULPRIDE; HALOPERIDOL; OLANZAPINE; RISPERIDONE;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; AKATHISIA; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BILIRUBIN BLOOD LEVEL; CASE REPORT; CHINESE; CHOLESTASIS; DISEASE COURSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ECHOGRAPHY; EXTRAPYRAMIDAL SYMPTOM; HEPATOMEGALY; HUMAN; JAUNDICE; LIVER FUNCTION TEST; MALE; PARKINSONISM; PSYCHOPHARMACOTHERAPY; SCHIZOPHRENIA; SIDE EFFECT; SPLENOMEGALY; TOXIC HEPATITIS; TREATMENT OUTCOME;

ADOLESCENT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CHINA; CHOLESTASIS; DRUG-INDUCED LIVER INJURY; HUMANS; MALE; SCHIZOPHRENIA; SPLENOMEGALY;

EID: 70350225837     PISSN: 10242708     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. de Abagjo FJ, Montero D, Madurga M, Garcia Rodriguez LA. Acute and clinically relevant drug-induced liver injury: a population based case-control study. Br J Clin Pharmacol 2004;58:71-80. (Pubitemid 38901470)
2. Hansen TE, Casey DE, Hoffman WF. Neuroleptic intolerance. Schizophr Bull 1997;23:567-582
3. Kolpe M, Ravasia S. Effect of olanzapine on the liver transaminases. Can J Psychiatry 2003;48:210.
4. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-245 (Pubitemid 11140804)
5. Fuller MA, Simon MR, Freedman L. Risperidone-associated hepatotoxicity. J Clin Psychopharmacol 1996;16:84-85
6. Cordeiro Q Jr, Elkis H. Pancreatitis and cholestatic hepatitis induced by risperidone. J Clin Psychopharmacol 2001;21:529-530 (Pubitemid 32937437)
7. Ozcanli T, Erdogan A, Ozdemir S, et al. Severe liver enzyme elevations after three years of olanzapine treatment: a case report and review of olanzapine associated hepatotoxicity. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1163-1166 (Pubitemid 43949429)
8. Thatcher GW, Cates M, Bair B. Clozapine-induced toxic hepatitis. Am J Psychiatry 1995;152:296-297
9. Hummer M, Kurz M, Kurzthaler I, Oberbauer H, Miller C, Fleischhacker WW. Hepatotoxicity of clozapine. J Clin Psychopharmacol 1997;17:314-317
10. Mesotten F, Suy E, Pietquin M, Burton P, Heylen S, Gelders Y. Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients. Psychopharmacology (Berl) 1989;99:445-449
11. El Hajj I, Sharara AI, Rockey DC. Subfulminant liver failure associated with quetiapine. Eur J Gasterenterol Hepatol 2004;16:1415-1418 (Pubitemid 39627546)
12. Taylor D, Paton C, Kerwin R. The Maudsley prescribing guidelines. 9th ed. UK: Informa Healthcare; 2007.
13. Holtmann M, Kopf D, Mayer M, Bechtinger E, Schmidt MH. Risperidone-associated steatohepatitis and excessive weight-gain. Pharmacopsychiatry 2003;36:206-207
14. Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotics drugs in patients with schizophrenia. N Engl J Med 2005;353:1209-1223 (Pubitemid 41345943)
15. Tchernichovsky E, Sirota P. Hepatotoxicity, leucopenia and neutropenia associated with olanzapine therapy. Int J Psychiatry Clin Pract 2004;8:173-177 (Pubitemid 39382089)