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Volumn 54, Issue 11, 2009, Pages 2530-2537

Serum alpha-fetoprotein levels during and after interferon therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis C

Author keywords

Alpha fetoprotein; Chronic hepatitis C; Hepatocellular carcinoma; Interferon

Indexed keywords

ALPHA FETOPROTEIN; ALPHA INTERFERON; CONSENSUS INTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN;

EID: 70350221879     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0642-y     Document Type: Article
Times cited : (28)

References (37)
  • 1
    • 0024421391 scopus 로고
    • Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis
    • 10.1016/S0140-6736(89)91015-5 10.1016/S0140-6736(89)91015-5
    • J Bruix JM Barrera X Calvet G Ercilla J Costa JM Sanchez-Tapias M Ventura M Vall M Bruguera C Bru 1989 Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis Lancet 334 1004 1046 10.1016/S0140-6736(89)91015-5 10.1016/S0140-6736(89)91015-5
    • (1989) Lancet , vol.334 , pp. 1004-1046
    • Bruix, J.1    Barrera, J.M.2    Calvet, X.3    Ercilla, G.4    Costa, J.5    Sanchez-Tapias, J.M.6    Ventura, M.7    Vall, M.8    Bruguera, M.9    Bru, C.10
  • 2
    • 0024450697 scopus 로고
    • Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma
    • 10.1016/S0140-6736(89)91016-7 10.1016/S0140-6736(89)91016-7
    • M Colombo G Kuo QL Choo MF Donato E Del Ninno MA Tommasini N Dioguardi M Houghton 1989 Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma Lancet 334 1006 1008 10.1016/S0140-6736(89)91016-7 10.1016/S0140-6736(89)91016-7
    • (1989) Lancet , vol.334 , pp. 1006-1008
    • Colombo, M.1    Kuo, G.2    Choo, Q.L.3    Donato, M.F.4    Del Ninno, E.5    Tommasini, M.A.6    Dioguardi, N.7    Houghton, M.8
  • 4
    • 0027229211 scopus 로고
    • A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis
    • 10.1002/hep.1840180109 7686879
    • K Ikeda S Saitoh I Koida Y Arase A Tsubota K Chayama H Kumada M Kawanishi 1993 A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis Hepatology 18 47 53 10.1002/hep.1840180109 7686879
    • (1993) Hepatology , vol.18 , pp. 47-53
    • Ikeda, K.1    Saitoh, S.2    Koida, I.3    Arase, Y.4    Tsubota, A.5    Chayama, K.6    Kumada, H.7    Kawanishi, M.8
  • 10
    • 0028876371 scopus 로고
    • Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis
    • 10.1016/S0140-6736(95)91739-X 10.1016/S0140-6736(95)91739-X 7564784
    • S Nishiguchi T Kuroki S Nakatani H Morimoto T Takeda S Nakajima S Shiomi S Seki K Kobayashi S Otani 1995 Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis Lancet 346 1051 1055 10.1016/S0140-6736(95)91739-X 10.1016/S0140-6736(95)91739-X 7564784
    • (1995) Lancet , vol.346 , pp. 1051-1055
    • Nishiguchi, S.1    Kuroki, T.2    Nakatani, S.3    Morimoto, H.4    Takeda, T.5    Nakajima, S.6    Shiomi, S.7    Seki, S.8    Kobayashi, K.9    Otani, S.10
  • 11
    • 0032898360 scopus 로고    scopus 로고
    • Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: A long-term observation study of 1, 643 patients using statistical bias correction with proportional hazard analysis
    • 10.1002/hep.510290439 10.1002/hep.510290439 10094956
    • K Ikeda S Saitoh Y Arase K Chayama Y Suzuki M Kobayashi A Tsubota I Nakamura N Murashima H Kumada M Kawanishi 1999 Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: a long-term observation study of 1, 643 patients using statistical bias correction with proportional hazard analysis Hepatology 29 1124 1130 10.1002/hep.510290439 10.1002/hep.510290439 10094956
    • (1999) Hepatology , vol.29 , pp. 1124-1130
    • Ikeda, K.1    Saitoh, S.2    Arase, Y.3    Chayama, K.4    Suzuki, Y.5    Kobayashi, M.6    Tsubota, A.7    Nakamura, I.8    Murashima, N.9    Kumada, H.10    Kawanishi, M.11
  • 12
    • 4844219782 scopus 로고    scopus 로고
    • Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy
    • DOI 10.1002/cncr.20537
    • A Makiyama Y Itoh A Kasahara Y Imai S Kawata K Yoshioka H Tsubouchi K Kiyosawa S Kakumu K Okita N Hayashi T Okanoue 2004 Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy Cancer 101 1616 1622 10.1002/cncr.20537 10.1002/cncr.20537 15378504 (Pubitemid 39318909)
    • (2004) Cancer , vol.101 , Issue.7 , pp. 1616-1622
    • Makiyama, A.1    Itoh, Y.2    Kasahara, A.3    Imai, Y.4    Kawata, S.5    Yoshioka, K.6    Tsubouchi, H.7    Kiyosawa, K.8    Kakumu, S.9    Okita, K.10    Hayashi, N.11    Okanoue, T.12
  • 13
    • 15844367468 scopus 로고    scopus 로고
    • Risk factors for development of hepatocellular carcinoma in patients with chronic hepatitis C after sustained response to interferon
    • DOI 10.1007/s00535-004-1519-2
    • M Ikeda S Fujiyama M Tanaka M Sata T Ide H Yatsuhashi H Watanabe 2005 Risk factors for development of hepatocellular carcinoma in patients with chronic hepatitis C after sustained response to interferon J Gastroenterol 40 148 156 10.1007/s00535-004-1519-2 10.1007/s00535-004-1519-2 15770398 (Pubitemid 40425202)
    • (2005) Journal of Gastroenterology , vol.40 , Issue.2 , pp. 148-156
    • Ikeda, M.1    Fujiyama, S.2    Tanaka, M.3    Sata, M.4    Ide, T.5    Yatsuhashi, H.6    Watanabe, H.7
  • 14
    • 0014307002 scopus 로고
    • Production of embryonal serum alpha-globulin by hepatoma: Review of experimental and clinical data
    • 4174340
    • GI Abelev 1968 Production of embryonal serum alpha-globulin by hepatoma: review of experimental and clinical data Cancer Res 28 1344 1350 4174340
    • (1968) Cancer Res , vol.28 , pp. 1344-1350
    • Abelev, G.I.1
  • 15
    • 0014790643 scopus 로고
    • A collaborative study for the evaluation of a serologic test for primary liver cancer
    • 10.1002/1097-0142(197005)25:5<1091::AID-CNCR2820250514>3.0.CO;2-P 10.1002/1097-0142(197005)25:5<1091::AID-CNCR2820250514>3.0.CO;2-P
    • GI Conor YS Tatarinov GI Abelev J Uriel 1970 A collaborative study for the evaluation of a serologic test for primary liver cancer Cancer 25 1091 1098 10.1002/1097-0142(197005)25:5<1091::AID-CNCR2820250514>3.0.CO;2-P 10.1002/1097-0142(197005)25:5<1091::AID-CNCR2820250514>3.0.CO;2-P
    • (1970) Cancer , vol.25 , pp. 1091-1098
    • Conor, G.I.1    Tatarinov, Y.S.2    Abelev, G.I.3    Uriel, J.4
  • 16
    • 0038023128 scopus 로고    scopus 로고
    • Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C
    • DOI 10.1111/j.1572-0241.1998.00703.x, PII S000292709800584X
    • N Bayati AL Silverman SC Gordon 1998 Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C Am J Gastroenterol 93 2452 2456 10.1111/j.1572-0241.1998.00703.x 10.1111/j.1572-0241.1998.00703.x 9860408 (Pubitemid 29018554)
    • (1998) American Journal of Gastroenterology , vol.93 , Issue.12 , pp. 2452-2456
    • Bayati, N.1    Silverman, A.L.2    Gordon, S.C.3
  • 17
    • 0032970057 scopus 로고    scopus 로고
    • Serum alpha-fetoprotein levels in patients with chronic hepatitis C. Relationships with serum alanine aminotransferase values, histologic activity index, and hepatocyte MIB-1 scores
    • 10361518
    • NS Goldstein DE Blue R Hankin S Hunter N Bayati AL Silverman SC Gordon 1999 Serum alpha-fetoprotein levels in patients with chronic hepatitis C. Relationships with serum alanine aminotransferase values, histologic activity index, and hepatocyte MIB-1 scores Am J Clin Pathol 111 811 816 10361518
    • (1999) Am J Clin Pathol , vol.111 , pp. 811-816
    • Goldstein, N.S.1    Blue, D.E.2    Hankin, R.3    Hunter, S.4    Bayati, N.5    Silverman, A.L.6    Gordon, S.C.7
  • 18
    • 0035116742 scopus 로고    scopus 로고
    • Clinical, virologic, and pathologic significance of elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C
    • DOI 10.1097/00004836-200103000-00014
    • CW Chu SJ Hwang JC Luo CR Lai SH Tsay CP Li JC Wu FY Chang SD Lee 2001 Clinical, virologic, and pathologic significance of elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C J Clin Gastroenterol 32 240 244 10.1097/00004836-200103000-00014 10.1097/00004836- 200103000-00014 11246354 (Pubitemid 32174119)
    • (2001) Journal of Clinical Gastroenterology , vol.32 , Issue.3 , pp. 240-244
    • Chu, C.-W.1    Hwang, S.-J.2    Luo, J.-C.3    Lai, C.-R.4    Tsay, S.-H.5    Li, C.-P.6    Wu, J.-C.7    Chang, F.-Y.8    Lee, S.-D.9
  • 19
    • 2942675194 scopus 로고    scopus 로고
    • Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma
    • DOI 10.1111/j.1572-0241.2004.04152.x
    • KQ Hu NL Kyulo N Lim B Elhazin DJ Hillebrand T Bock 2004 Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma Am J Gastroenterol 99 860 865 10.1111/j.1572-0241.2004.04152.x 10.1111/j.1572-0241.2004.04152.x 15128351 (Pubitemid 39090214)
    • (2004) American Journal of Gastroenterology , vol.99 , Issue.5 , pp. 860-865
    • Hu, K.-Q.1    Kyulo, N.L.2    Lim, N.3    Elhazin, B.4    Hillebrand, D.J.5    Bock, T.6
  • 21
    • 33645848470 scopus 로고    scopus 로고
    • A decrease in AFP level related to administration of interferon in patients with chronic hepatitis C and a high level of AFP
    • 10.1007/s10620-006-3211-2 10.1007/s10620-006-3211-2 16615008
    • S Murashima M Tanaka M Haramaki S Yutani Y Nakashima K Harada T Ide R Kumashiro M Sata 2006 A decrease in AFP level related to administration of interferon in patients with chronic hepatitis C and a high level of AFP Dig Dis Sci 51 808 812 10.1007/s10620-006-3211-2 10.1007/s10620-006-3211-2 16615008
    • (2006) Dig Dis Sci , vol.51 , pp. 808-812
    • Murashima, S.1    Tanaka, M.2    Haramaki, M.3    Yutani, S.4    Nakashima, Y.5    Harada, K.6    Ide, T.7    Kumashiro, R.8    Sata, M.9
  • 22
    • 34247214966 scopus 로고    scopus 로고
    • Predictors of alpha-fetoprotein elevation in patients with chronic hepatitis C, but not hepatocellular carcinoma, and its normalization after pegylated interferon alfa 2a-ribavirin combination therapy
    • 17444854
    • TM Chen PT Huang MH Tsai LF Lin CC Liu KS Ho CP Siauw PL Chao JN Tung 2007 Predictors of alpha-fetoprotein elevation in patients with chronic hepatitis C, but not hepatocellular carcinoma, and its normalization after pegylated interferon alfa 2a-ribavirin combination therapy J Gastroenterol Hepatol 22 669 675 17444854
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 669-675
    • Chen, T.M.1    Huang, P.T.2    Tsai, M.H.3    Lin, L.F.4    Liu, C.C.5    Ho, K.S.6    Siauw, C.P.7    Chao, P.L.8    Tung, J.N.9
  • 23
    • 34249889291 scopus 로고    scopus 로고
    • Efficacy of low dose long-term interferon monotherapy in aged patients with chronic hepatitis C genotype 1 and its relation to alpha-fetoprotein: A pilot study
    • DOI 10.1111/j.1872-034X.2007.00073.x
    • H Nomura Y Kashiwagi R Hirano H Tanimoto N Tsutsui M Higashi H Ishibashi 2007 Efficacy of low-dose long-term interferon monotherapy in aged patients with chronic hepatitis C genotype 1 and its relation to alpha-fetoprotein: a pilot study Hepatol Res 37 490 497 10.1111/j.1872-034X.2007.00073.x 10.1111/j.1872-034X.2007.00073.x 17539990 (Pubitemid 46864243)
    • (2007) Hepatology Research , vol.37 , Issue.7 , pp. 490-497
    • Nomura, H.1    Kashiwagi, Y.2    Hirano, R.3    Tanimoto, H.4    Tsutsumi, N.5    Higashi, M.6    Ishibashi, H.7
  • 27
    • 0027154890 scopus 로고
    • Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein
    • DOI 10.1056/NEJM199306243282502
    • Y Sato K Nakata Y Kato M Shima N Ishii T Koji K Taketa Y Endo S Nagataki 1993 Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein N Engl J Med 328 1802 1806 10.1056/NEJM199306243282502 10.1056/NEJM199306243282502 7684823 (Pubitemid 23174710)
    • (1993) New England Journal of Medicine , vol.328 , Issue.25 , pp. 1802-1806
    • Sato, Y.1    Nakata, K.2    Kato, Y.3    Shima, M.4    Ishii, N.5    Koji, T.6    Taketa, K.7    Endo, Y.8    Nagataki, S.9
  • 29
    • 0022550757 scopus 로고
    • Transcriptional switch from albumin to alpha-fetoprotein and changes in transcription of other genes during carbon tetrachloride induced liver regeneration
    • 10.1021/bi00354a034 10.1021/bi00354a034 2421766
    • A Panduro F Shalaby FR Weiner L Biempica MA Zern DA Shafritz 1986 Transcriptional switch from albumin to alpha-fetoprotein and changes in transcription of other genes during carbon tetrachloride induced liver regeneration Biochemistry 25 1414 1420 10.1021/bi00354a034 10.1021/bi00354a034 2421766
    • (1986) Biochemistry , vol.25 , pp. 1414-1420
    • Panduro, A.1    Shalaby, F.2    Weiner, F.R.3    Biempica, L.4    Zern, M.A.5    Shafritz, D.A.6
  • 30
    • 0032498556 scopus 로고    scopus 로고
    • Stimulation of tumor-cell growth by alpha-fetoprotein
    • DOI 10.1002/(SICI)1097-0215(19980209)75:4<596::AID-IJC17>3.0.CO;2-7
    • XW Wang B Xu 1998 Stimulation of tumor-cell growth by alpha-fetoprotein Int J Cancer 75 596 599 10.1002/(SICI)1097-0215(19980209)75:4<596::AID- IJC17>3.0.CO;2-7 10.1002/(SICI)1097-0215(19980209)75:4<596::AID- IJC17>3.0.CO;2-7 9466662 (Pubitemid 28094107)
    • (1998) International Journal of Cancer , vol.75 , Issue.4 , pp. 596-599
    • Wang, X.-W.1    Xu, B.2
  • 31
    • 0032573632 scopus 로고    scopus 로고
    • Alpha - Fetoprotein enhances the proliferation of human hepatoma cells in vitro
    • DOI 10.1016/S0024-3205(98)00529-3, PII S0024320598005293
    • XW Wang H Xie 1999 Alpha-fetoprotein enhances the proliferation of human hepatoma cells in vitro Life Sci 64 17 23 10.1016/S0024-3205(98)00529-3 10.1016/S0024-3205(98)00529-3 10027738 (Pubitemid 29012745)
    • (1999) Life Sciences , vol.64 , Issue.1 , pp. 17-23
    • Wang, X.-W.1    Xie, H.2
  • 32
    • 1842587679 scopus 로고    scopus 로고
    • Alpha-fetoprotein stimulated the expression of some oncogenes in human hepatocellular carcinoma Bel 7402 cells
    • 15040024
    • MS Li PF Li Q Chen GG Du G Li 2004 Alpha-fetoprotein stimulated the expression of some oncogenes in human hepatocellular carcinoma Bel 7402 cells World J Gastroenterol 10 819 824 15040024
    • (2004) World J Gastroenterol , vol.10 , pp. 819-824
    • Li, M.S.1    Li, P.F.2    Chen, Q.3    Du, G.G.4    Li, G.5
  • 33
    • 18944374561 scopus 로고    scopus 로고
    • Alpha-fetoprotein triggers hepatoma cells escaping from immune surveillance through altering the expression of Fas/FasL and tumor necrosis factor related apoptosis-inducing ligand and its receptor of lymphocytes and liver cancer cells
    • 15849812
    • MS Li QL Ma Q Chen XH Liu PF Li GG Du G Li 2005 Alpha-fetoprotein triggers hepatoma cells escaping from immune surveillance through altering the expression of Fas/FasL and tumor necrosis factor related apoptosis-inducing ligand and its receptor of lymphocytes and liver cancer cells World J Gastroenterol 11 2564 2569 15849812
    • (2005) World J Gastroenterol , vol.11 , pp. 2564-2569
    • Li, M.S.1    Ma, Q.L.2    Chen, Q.3    Liu, X.H.4    Li, P.F.5    Du, G.G.6    Li, G.7
  • 34
    • 84984548367 scopus 로고    scopus 로고
    • Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan
    • DOI 10.1053/j.gastro.2008.03.073, PII S0016508508005696
    • CL Chen HI Yang WS Yang CJ Liu PJ Chen SL You LY Wang CA Sun SN Lu DS Chen CJ Chen 2008 Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan Gastroenterology 135 111 121 10.1053/j.gastro.2008.03.073 10.1053/j.gastro.2008.03.073 18505690 (Pubitemid 351899021)
    • (2008) Gastroenterology , vol.135 , Issue.1 , pp. 111-121
    • Chen, C.1    Yang, HwaiI.2    Yang, W.3    Liu, C.4    Chen, P.5    You, S.6    Wang, L.7    Sun, C.8    Lu, S.9    Chen, D.10    Chen, C.11
  • 35
    • 0036829556 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus
    • DOI 10.1053/jhep.2002.36780
    • MM Hassan LY Hwang CJ Hatten M Swaim D Li JL Abbruzzese P Beasley YZ Patt 2002 Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus Hepatology 36 1206 1213 10.1053/jhep.2002.36780 10.1053/jhep.2002.36780 12395331 (Pubitemid 35253437)
    • (2002) Hepatology , vol.36 , Issue.2-5 , pp. 1206-1213
    • Hassan, M.M.1    Hwang, L.-Y.2    Hatten, C.J.3    Swaim, M.4    Li, D.5    Abbruzzese, J.L.6    Beasley, P.7    Patt, Y.Z.8
  • 36
    • 4143065907 scopus 로고    scopus 로고
    • Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S.
    • DOI 10.1002/cncr.20427
    • JM Yuan S Govindarajan K Arakawa MC Yu 2004 Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the US Cancer 101 1009 1017 10.1002/cncr.20427 10.1002/cncr.20427 15329910 (Pubitemid 39100435)
    • (2004) Cancer , vol.101 , Issue.5 , pp. 1009-1017
    • Yuan, J.-M.1    Govindarajan, S.2    Arakawa, K.3    Yu, M.C.4
  • 37
    • 0029947938 scopus 로고    scopus 로고
    • The role of previous hepatitis B virus infection and heavy smoking in hepatitis C virus-related hepatocellular carcinoma
    • 8651170
    • T Chiba Y Matsuzaki M Abei J Shoda N Tanaka T Osuga T Aikawa 1996 The role of previous hepatitis B virus infection and heavy smoking in hepatitis C virus-related hepatocellular carcinoma Am J Gastroenterol 91 1195 1203 8651170
    • (1996) Am J Gastroenterol , vol.91 , pp. 1195-1203
    • Chiba, T.1    Matsuzaki, Y.2    Abei, M.3    Shoda, J.4    Tanaka, N.5    Osuga, T.6    Aikawa, T.7


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