Sustained release dosage forms dissolution behavior prediction: A study of matrix tablets using NIR spectroscopy

International Journal of Pharmaceutics

Volumn 382, Issue 1-2, 2009, Pages 1-6

  Tabasi, Simin Hassannejad ^a,c   Moolchandani, Vikas ^a   Fahmy, Raafat ^b   Hoag, Stephen W ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c Perrigo Company   (United States)

Author keywords

Chemometrics; Dissolution prediction; Drug release prediction; Matrix formulation; Multivariate calibration; NIR spectroscopy

Indexed keywords

ACETIC ACID; BUFFER; EUDRAGIT; THEOPHYLLINE;

ARTICLE; CALIBRATION; CHEMOMETRICS; CONTROLLED STUDY; DIFFUSE REFLECTANCE SPECTROSCOPY; DRUG SOLUBILITY; MATRIX TABLET; NEAR INFRARED SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PREDICTION; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION;

BUFFERS; CALIBRATION; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EXCIPIENTS; FEASIBILITY STUDIES; HYDROGEN-ION CONCENTRATION; KINETICS; LEAST-SQUARES ANALYSIS; METHACRYLATES; MODELS, CHEMICAL; POLYMERS; PRINCIPAL COMPONENT ANALYSIS; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SPECTROSCOPY, NEAR-INFRARED; TABLETS; TECHNOLOGY, PHARMACEUTICAL; THEOPHYLLINE;

EID: 70350211448     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.07.029     Document Type: Article

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