Quantification of the multiplexing effects in multi-pinhole small animal SPECT: A simulation study

IEEE Transactions on Nuclear Science

Volumn 56, Issue 5, 2009, Pages 2636-2643

  Mok, Greta S P ^a   Wang, Yuchuan ^b   Tsui, Benjamin M W ^c  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b HARVARD MEDICAL SCHOOL   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Multi pinhole collimator; Multiplexing; Small animal imaging; SPECT

Indexed keywords

DATA SETS; DETECTION EFFICIENCY; GAMMA CAMERAS; IMAGE CONTRASTS; IMAGE DEGRADATION; IMAGE NOISE; MULTI-PINHOLE COLLIMATOR; NOISE REALIZATIONS; NOISY DATA; PINHOLE COLLIMATORS; POISSON NOISE; QUANTITATIVE ACCURACY; RECONSTRUCTED IMAGE; RECONSTRUCTION METHOD; SIMULATION STUDIES; SMALL ANIMAL; SMALL ANIMAL IMAGING; SPECT; SPECT IMAGING; WHOLE BODY;

ANIMALS; CAMERAS; COMMERCE; DEGRADATION; IMAGE RECONSTRUCTION; IMAGE RESOLUTION; THREE DIMENSIONAL;

MULTIPLEXING;

EID: 70350191784     PISSN: 00189499     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNS.2009.2023444     Document Type: Article

References (16)

1. R. J. Jaszczak, J. Y. Li, H. L.Wang, M. R. Zalutsky, and R. E. Coleman, "Pinhole collimation for ultra-high-resolution, small-field-of-view Spect," Phys. Med. Biol., vol.39, pp. 425-437, 1994.
2. S. R. Meikle, P. Kench, M. Kassiou, and R. B. Banati, "Small animal SPECT and its place in the matrix of molecular imaging technologies," Phys. Med. Biol., vol.50, pp. R45-R61, 2005.
3. G. S. P. Mok, B. M. W. Tsui, Y.Wang, Y. Du, W. Segars, and E. Frey, "Effects of pinhole pattern and multiplexing in multi-pinhole small animal SPECT," presented at the 52nd Ann. Meet. Soc. Nucl. Med., Toronto, Canada, 2005.
4. F. J. Beekman and B. Vastenhouw, "Design and simulation of a highresolution stationary SPECT system for small animals," Phys. Med. Biol., vol.49, pp. 4579-4592, 2004.
5. N. U. Schramm, G. Ebel, U. Engeland, T. Schurrat, M. Behe, and T. M. Behr, "High-resolution SPECT using multipinhole collimation," IEEE Trans. Nucl. Sci., vol.50, no.3, pp. 315-320, Jun. 2003.
6. K. Vunckx, P. Suetens, and J. Nuyts, "Effect of overlapping projections on reconstruction image quality in multipinhole SPECT," IEEE Trans. Med. Imag., vol.27, no.7, pp. 972-983, Jul. 2008.
7. W. P. Segars, B. M. W. Tsui, E. C. Frey, G. A. Johnson, and S. S. Berr, "Development of a 4-D digital mouse phantom for molecular imaging research," Molecular Imag. Biol., vol.6, pp. 149-159, 2004.
8. Z. Cao, G. Bal, R. Accorsi, and P. D. Acton, "Optimal number of pinholes in multi-pinhole SPECT for mouse brain imaging-a simulation study," Phys. Med. Biol., vol.50, no.19, pp. 4609-4624, 2005.
9. Y. Wang and B. M. W. Tsui, "Application of crosstalk concept to assessment of multi-pinhole collimator designs in small animal SPECT imaging," presented at the IEEE Nucl. Sci. Symp. Med. Imag. Conf., San Diego, USA, 2006.
10. K. Vunckx, D. Beque, M. Defrise, and J. Nuyts, "Single and multipinhole collimator design evaluation method for small animal SPECT," IEEE Trans. Med. Imag., vol.27, no.1, pp. 36-46, Jan. 2008.
11. D. W. Wilson, H. H. Barrett, and E. W. Clarkson, "Reconstruction of two- and three-dimensional images from synthetic-collimator data," IEEE Trans. Med. Imag., vol.19, no.5, pp. 412-422, May 2000.
12. G. Bal, G. L. Zeng, R. M. Lewitt, Z. Cao, and P. D. Acton, "Study of different pinhole configurations for small animal tumor imaging," in Proc. IEEE Nucl. Sci. Symp. Conf. Rec., 2004, vol.5, pp. 3133-3137.
13. K. Vunckx, J. Nuyts, B. Vanbilloen, M. D. Saint-Hubert, D. Vanderghinste, D. Rattat, F. M. Mottaghy, and M. Defrise, "Optimized multipinhole design for mouse imaging," in Proc. IEEE Nucl. Sci. Symp. Conf. Rec., 2008, pp. 4742-4750.
14. S. R. Meikle, P. Kench, A. G.Weisengberger, R. Wojcik, M. F. Smith, S. Majewski, S. Eberl, R. R. Fulton, A. B. Rosenfeld, and M. J. Fulham, "A prototype coded aperture detector for small animal SPECT," IEEE Trans. Nucl. Sci., vol.49, no.5, pp. 2167-2171, Oct. 2002.
15. F. J. Beekman, F. van der Have, B.Vastenhouw,A. J.A. van der Linden, P. P. van Rijk, J. P. H. Burbach, and M. P. Smidt, "U-SPECT-I: A novel system for submillimeter-resolution tomography with radiolabeled molecules in mice," J. Nucl. Med., vol.46, pp. 1194-1200, 2005.
16. C. E. Metz, "ROC methodology in radiologic imaging," Invest Radiol., vol.21, no.9, pp. 720-733, Sep. 1986.