Increased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis

Journal of Clinical Periodontology

Volumn 36, Issue 11, 2009, Pages 933-939

  Li, Xiao ^a   Tse, Hung Fat ^b   Yiu, Kai Hang ^b   Jia, Na ^b   Chen, Hua ^b   Li, Leonard Sheung Wai ^a   Jin, Lijian ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Department of Medicine

Author keywords

C reactive protein; Endothelial function; Endothelial progenitor cells; Periodontitis

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CD133 ANTIGEN; CD34 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; VASCULOTROPIN RECEPTOR 2;

ADULT; AGE; AGED; ARTICLE; BLOOD; CAROTID ARTERY; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; EDUCATIONAL STATUS; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; GINGIVA BLEEDING; GINGIVA DISEASE; HUMAN; INTIMA; MALE; MIDDLE AGED; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL POCKET; SEX DIFFERENCE; STEM CELL; TUNICA MEDIA; WAIST HIP RATIO;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD34; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CAROTID ARTERIES; CHRONIC PERIODONTITIS; EDUCATIONAL STATUS; ENDOTHELIAL CELLS; FEMALE; FLOW CYTOMETRY; GINGIVAL HEMORRHAGE; GINGIVAL RECESSION; GLYCOPROTEINS; HUMANS; MALE; MIDDLE AGED; PEPTIDES; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; SEX FACTORS; STEM CELLS; TUNICA INTIMA; TUNICA MEDIA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; WAIST-HIP RATIO;

EID: 70350191506     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2009.01481.x     Document Type: Article

References (49)

1. Abbas, M., Bignamini, V. Corea, F. (2006) Effects of chronic microbial infection on atherosclerosis. Atherosclerosis 187, 439 440.
2. Amar, S., Gokce, N., Morgan, S., Loukideli, M., Van Dyke, T. E. Vita, J. A. (2003) Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arteriosclerosis, Thrombosis and Vascular Biology 23, 1245 1249.
3. Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G. Isner, J. M. (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275, 964 967.
4. Beck, J. D., Eke, P., Lin, D., Madianos, P., Couper, D., Moss, K., Elter, J., Heiss, G. Offenbacher, S. (2005) Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults. Atherosclerosis 183, 342 348.
5. Beck, J. D., Elter, J. R., Heiss, G., Couper, D., Mauriello, S. M. Offenbacher, S. (2001) Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arteriosclerosis, Thrombosis and Vascular Biology 21, 1816 1822. (Pubitemid 34219786)
6. Behle, J. H., Sedaghatfar, M. H., Demmer, R. T., Wolf, D. L., Celenti, R., Kebschull, M., Belusko, P. B., Herrera-Abreu, M., Lalla, E. Papapanou, P. N. (2009) Heterogeneity of systemic inflammatory responses to periodontal therapy. Journal of Clinical Periodontology 36, 287 294.
7. Blum, A., Kryuger, K., Mashiach Eizenberg, M., Tatour, S., Vigder, F., Laster, Z. Front, E. (2007) Periodontal care may improve endothelial function. European Journal of Internal Medicine 18, 295 298. (Pubitemid 46898777)
8. Buhlin, K., Gustafsson, A., Pockley, A. G., Frostegard, J. Klinge, B. (2003) Risk factors for cardiovascular disease in patients with periodontitis. European Heart Journal 24, 2099 2107.
9. Buhlin, K., Hultin, M., Norderyd, O., Persson, L., Pockley, A. G., Rabe, P., Klinge, B. Gustafsson, A. (2009) Risk factors for atherosclerosis in cases with severe periodontitis. Journal of Clinical Periodontology 36, 541 549.
10. Cairo, F., Castellani, S., Gori, A. M., Nieri, M., Baldelli, G., Abbate, R. Pini-Prato, G. P. (2008) Severe periodontitis in young adults is associated with sub-clinical atherosclerosis. Journal of Clinical Periodontology 35, 465 472.
11. Corbet, E. F. (2007) Public health aspects of oral diseases and disorders - periodontal diseases. In : Pine, C. M. Harris, R. V. (eds). Community Oral Health, 2nd edition, pp. 177 189. Surrey : Quintessence.
12. D'Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D. Tonetti, M. S. (2004) Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. Journal of Dental Research 83, 156 160.
13. D'Aiuto, F., Parkar, M., Nibali, L., Suvan, J., Lessem, J. Tonetti, M. S. (2006) Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. American Heart Journal 151, 977 984.
14. Elter, J. R., Hinderliter, A. L., Offenbacher, S., Beck, J. D., Caughey, M., Brodala, N. Madianos, P. N. (2006) The effects of periodontal therapy on vascular endothelial function: a pilot trial. American Heart Journal 151, 47.e1 47.e6.
15. Fadini, G. P., de Kreutzenberg, S. V., Coracina, A., Baesso, I., Agostini, C., Tiengo, A. Avogaro, A. (2006) Circulating CD34+ cells, metabolic syndrome, and cardiovascular risk. European Heart Journal 27, 2247 2255.
16. Faulx, M. D., Wright, A. T. Hoit, B. D. (2003) Detection of endothelial dysfunction with brachial artery ultrasound scanning. American Heart Journal 145, 943 951.
17. Fokkema, S. J., Loos, B. G., Hart, A. A. van der Velden, U. (2003) Long-term effect of full-mouth tooth extraction on the responsiveness of peripheral blood monocytes. Journal of Clinical Periodontology 30, 756 760.
18. Fujii, H., Li, S. H., Szmitko, P. E., Fedak, P. W. Verma, S. (2006) C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells. Arteriosclerosis, Thrombosis and Vascular Biology 26, 2476 2482.
19. Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Nedeljkovic, Z. S., Menzoian, J. O. Vita, J. A. (2003) Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. Journal of the American College of Cardiology 41, 1769 1775.
20. Hill, J. M., Zalos, G., Halcox, J. P., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A. Finkel, T. (2003) Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New England Journal of Medicine 348, 593 600.
21. Hristov, M., Erl, W. Weber, P. C. (2003) Endothelial progenitor cells: mobilization, differentiation, and homing. Arteriosclerosis, Thrombosis and Vascular Biology 23, 1185 1189. (Pubitemid 36871271)
22. Jie, K. E., Goossens, M. H., van Oostrom, O., Lilien, M. R. Verhaar, M. C. (2009) Circulating endothelial progenitor cell levels are higher during childhood than in adult life. Atherosclerosis 202, 345 347.
23. Jin, L. J. (2008) Periodontal infections, systemic inflammation and cardiovascular disease: current evidence and perspectives. In : Bartold, P. M., Ishikawa, I. Zhang, J. (eds). A Perspective of Periodontal Systemic Relationships for the Asian Pacific Region, pp. 114 121. Adelaide : Asian Pacific Society of Periodontology.
24. Joshi, A., Douglass, C. W., Feldman, H., Mitchell, P. Jette, A. (1996) Consequences of success: do more teeth translate into more disease and utilization? Journal of Public Health Dentistry 56, 190 197.
25. Joshipura, K. J., Wand, H. C., Merchant, A. T. Rimm, E. B. (2004) Periodontal disease and biomarkers related to cardiovascular disease. Journal of Dental Research 83, 151 155.
26. Katz, J., Chaushu, G. Sharabi, Y. (2001) On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. Journal of Clinical Periodontology 28, 865 868.
27. Katz, J., Flugelman, M. Y., Goldberg, A. Heft, M. (2002) Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. Journal of Periodontology 73, 494 500.
28. Kshirsagar, A. V., Offenbacher, S., Moss, K. L., Barros, S. P. Beck, J. D. (2007) Antibodies to periodontal organisms are associated with decreased kidney function. The dental atherosclerosis risk in communities study. Blood Purification 25, 125 132.
29. Kunz, G. A., Liang, G., Cuculi, F., Gregg, D., Vata, K. C., Shaw, L. K., Goldschmidt-Clermont, P. J., Dong, C., Taylor, D. A. Peterson, E. D. (2006) Circulating endothelial progenitor cells predict coronary artery disease severity. American Heart Journal 152, 190 195.
30. Lau, K. K., Chan, Y. H., Yiu, K. H., Li, S. W., Tam, S., Lau, C. P., Kwong, Y. L. Tse, H. F. (2007) Burden of carotid atherosclerosis in patients with stroke: relationships with circulating endothelial progenitor cells and hypertension. Journal of Human Hypertension 21, 445 451.
31. Loos, B. G., Craandijk, J., Hoek, F. J., Wertheim-van Dillen, P. M. van der Velden, U. (2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. Journal of Periodontology 71, 1528 1534.
32. Mercanoglu, F., Oflaz, H., Oz, O., Gokbuget, A. Y., Genchellac, H., Sezer, M., Nisanci, Y. Umman, S. (2004) Endothelial dysfunction in patients with chronic periodontitis and its improvement after initial periodontal therapy. Journal of Periodontology 75, 1694 1700.
33. Montebugnoli, L., Servidio, D., Miaton, R. A., Prati, C., Tricoci, P. Melloni, C. (2004) Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors. Journal of Clinical Periodontology 31, 25 29.
34. Montebugnoli, L., Servidio, D., Miaton, R. A., Prati, C., Tricoci, P., Melloni, C. Melandri, G. (2005) Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease. Journal of Clinical Periodontology 32, 188 192.
35. Page, R. C. Eke, P. I. (2007) Case definitions for use in population-based surveillance of periodontitis. Journal of Periodontology 78, 1387 1399.
36. Piconi, S., Trabattoni, D., Luraghi, C., Perilli, E., Borelli, M., Pacei, M., Rizzardini, G., Lattuada, A., Bray, D. H., Catalano, M., Sparaco, A. Clerici, M. (2009) Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness. The FASEB Journal 23, 1196 1204.
37. Pussinen, P. J., Jauhiainen, M., Vilkuna-Rautiainen, T., Sundvall, J., Vesanen, M., Mattila, K., Palosuo, T., Alfthan, G. Asikainen, S. (2004) Periodontitis decreases the antiatherogenic potency of high density lipoprotein. Journal of Lipid Research 45, 139 147.
38. Pussinen, P. J., Jousilahti, P., Alfthan, G., Palosuo, T., Asikainen, S. Salomaa, V. (2003) Antibodies to periodontal pathogens are associated with coronary heart disease. Arteriosclerosis, Thrombosis and Vascular Biology 23, 1250 1254.
39. Schenkein, H. A., Gunsolley, J. C., Best, A. M., Harrison, M. T., Hahn, C. L., Wu, J. Tew, J. G. (1999) Antiphosphorylcholine antibody levels are elevated in humans with periodontal diseases. Infection and Immunity 67, 4814 4818.
40. Seinost, G., Wimmer, G., Skerget, M., Thaller, E., Brodmann, M., Gasser, R., Bratschko, R. O. Pilger, E. (2005) Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis. American Heart Journal 149, 1050 1054.
41. Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J. M. Asahara, T. (1999) Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nature Medicine 5, 434 438. (Pubitemid 29180584)
42. Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P. Deanfield, J. (2007) Treatment of periodontitis and endothelial function. New England Journal of Medicine 356, 911 920.
43. Tu, Y. K., Galobardes, B., Smith, G. D., McCarron, P., Jeffreys, M. Gilthorpe, M. S. (2007) Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort. Heart 93, 1098 1103.
44. Verma, S., Kuliszewski, M. A., Li, S. H., Szmitko, P. E., Zucco, L., Wang, C. H., Badiwala, M. V., Mickle, D. A., Weisel, R. D., Fedak, P. W., Stewart, D. J. Kutryk, M. J. (2004) C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation 109, 2058 2067.
45. Wang, H. Y., Gao, P. J., Ji, K. D., Shen, W. F., Fan, C. L., Lu, L. Zhu, D. L. (2007) Circulating endothelial progenitor cells, C-reactive protein and severity of coronary stenosis in Chinese patients with coronary artery disease. Hypertension Research 30, 133 141.
46. Williams, R. C. Paquette, D. (2003) Periodontitis as a risk for systemic disease. In : Lindhe, J., Lang, N.P. Karring, K. (eds). Clinical Periodontology and Implant Dentistry, 4th edition, pp. 366 386. Oxford : Blackwell Munksgaard.
47. Wojakowski, W., Kucia, M., Kazmierski, M., Ratajczak, M. Z. Tendera, M. (2008) Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: relevant reparatory mechanism? Heart 94, 27 33.
48. Yamada, M., Kubo, H., Ishizawa, K., Kobayashi, S., Shinkawa, M. Sasaki, H. (2005) Increased circulating endothelial progenitor cells in patients with bacterial pneumonia: evidence that bone marrow derived cells contribute to lung repair. Thorax 60, 410 413.
49. Yamada, M., Kubo, H., Kobayashi, S., Ishizawa, K., Numasaki, M., Ueda, S., Suzuki, T. Sasaki, H. (2004) Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. Journal of Immunology 172, 1266 1272.