Toxicological assessment on extracts of Phyllanthus amarus Schum and Thonn

Scientific Research and Essays

Volumn 3, Issue 9, 2008, Pages 410-415

  Lawson Evi, Povi ^a,b   Eklu Gadegbeku, Kwashie ^a   Agbonon, Amegnona ^a   Aklikokou, Kodjo ^a   Moukha, Serge ^b   Creppy, Edmond E ^b   Gbéassor, Messanvi ^a  

^a UNIVERSITY OF LOMÉ   (Togo)

^b Laboratory of Toxicology and Applied Hygiene   (France)

Author keywords

Caco 2 cells; In vitro toxicity; Phyllanthus amarus; Rat; Sub acute toxicity

Indexed keywords

ANIMALIA; MUS; PHYLLANTHUS AMARUS; RATTUS; RATTUS NORVEGICUS;

EID: 70350161609     PISSN: None     EISSN: 19922248     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Adedapo AA, Adegbayibi AY, Emipke BO (2005a). Some clinico-patho- logical changes associated with the aqueous extract of the leaves of Phyllanthus amarus in rats. Phytother. Res. 19: 971-976.
2. Adedapo AA, Obatan MO, Idowu SO, Olorunsogo OO (2005b). Toxic effect of chromatographic fractions of Phyllanthus amarus on the serum biochemistry of rats. Phytother. Res. 19: 812-815.
3. Butler LG (1992). Antinutritional effects of condensed and hydrolysable tannins. Basic Lif. Sci. 59: 693-698.
4. Carbonaro M, Grant G, Pusztai A (2001). Evaluation of polyphenol bioavailability in Rat small intestine. Eur. J. Nutr. 40: 84-90.
5. Català A (2007). The ability of melatonin to counteract lipid peroxidation in biological membranes. Curr. Mol. Med. 7: 638-649.
6. Derelanko MJ (2000). General information In: Toxicologist's Pocket Handbook CRC Press, Washington DC.pp.167-200.
7. Ferguson MA, Vaidya VS, Bonventre JV (2008). Biomarkers of nephrotoxic acute kidney injury. Toxicol. 20:182-193.
8. Gbeassor M, Agama Y, Denke AM, Amegbo A (1988). Contribution aux études pharmacologiques de Phyllanthus amarus. Afr. Méd. 27: 117-119.
9. Houghton PJ, Woldemariam TZ, O'Shea S, Thyagarajan SP (1996). Two securinega-type alkaloids from Phyllanthus amarus. Phytochem. 43: 715-717.
10. Kloucek P, Polesny Z, Svobodova B, Vlkova E, Kokoska L (2005). Antibacterial screening of some Peruvian medicinal plants used in Calleria District. J. Ethnopharmacol. 99: 309-312.
11. Kumar KB, Kuttan R (2005). Chemoprotective activity of an extract of Phyllanthus Amarus against cyclophosphamide induced toxicity in mice. Phytomed. 12: 494-500.
12. Lawson-Evi P, Eklu-Gadegbeku K, Aklikokou AK, Gbeassor M (1997). Activité hypoglycémiante de quelques plantes médicinales. Pharm. Med. Trad. Afr. 9: 60-69.
13. Lee WM (1993). Drug-induced hepatotoxicity. Alim Pharmacol Ther 7: 477-485.
14. Mazumder A, Mahato A, Mazumder R (2006). Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens. Nat. Prod. Res. 20: 323-326.
15. Moshi MJ, Lutale JK, Rimoy GH, Abbas ZG, Josiah RM, Swai AB (2001). The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother. Res. 15: 577-580.
16. Munshi A, Mehrotra R, Ramesh R, Panda SK (1993). Evaluation of anti- Hepadnavirus activity of Phyllanthus amarus and Phyllanthus maderaspatensis in duck hepatitis B virus carrier Pekin ducks. J. Med. Virol. 41: 275-281.
17. Nara TK, Gleye J, Cerval EL, Stanistan E (1977). Flavonoids of Phyllanthus niruri, Phyllanthus urinaria, Phyllanthus orbiculatus. Plan. Méd. Phytothér. 11: 82-86.
18. Notka F, Meier GR, Wagner R (2003). Inhibition of wild-type human Immunodeficiency virus and reverse transcriptase inhibitor-resistant variants by Phyllanthus amarus. Antiv. Res. 58: 175-186.
19. Polya GM, Wang BH, Fooly LY (1995). Inhibition of signal regulated protein kinase by plant derived hydrolysable tannins. Phytochem. 38: 307-314.
20. Raphael KR, Ajith TA, Joseph S, Kuttan R (2002a). Anti-mutagenic activity of Phyllanthus amarus Schum & Thonn in vitro as well as in vivo. Teratog. Carcinog. Mutagen. 22: 285-291.
21. Raphael KR, Sabu MC, Kuttan R (2002b). Hypoglycemic effect of methanol extract of Phyllanthus amarus Schum and Thonn on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential. Ind. J. Exp. Biol. 40: 905-909.
22. 13C-nmr assignements of Phyllanthin and Hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells. J. Nat. Prod. 56: 233-239.
23. Sripanidkulchai B, Tattawasart U, Laupatarakasem P, Vinitketkumneur U, Sripanidkulchai K, Furihata C, Matsushima T (2002). Antimutagenic and anticarcinogenic effects of Phyllanthus amarus. Phytomed. 9: 26-32.
24. Srividya N, Perival S (1995). Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Ind. J. Exp. Biol. 33: 861-864.
25. Sturgill MG, Lambert GH (1997). Xenobiotic-induced hepatotoxicity: mechanisms of Liver and methods of monitoring hepatic function. Clin. Chem. 43: 1512-1526.
26. Subcommittee on biologic Markers in Urinary Toxicology, Committee on Biologic Markers. (2002). Biologic Markers in Urinary Toxicology. National Academy Press, Washington DC, USA.
27. Syamasundar KV, Singh B, Thakur RS, Husain A, Kiso Y, Hikino H (1985). Antihepatotoxic principles of Phyllanthus niruri herb. J. Ethnopharmacol. 14: 41-44.
28. Thamlikitkul V, Wasuwat S, Kanchanapee PJ (1991). Efficacy of Phyllanthus amarus For eradication of hepatitis B virus in chronic carriers. Med. Assoc. Thai. 74: 381-385.
29. Yeh SF, Hong CY, Huang YL, Liu TY, Choo KB, Chou CK (1993). Effect of an extract from Phyllanthus amarus on hepatitis B surface antigen gene expression in human hepatoma cells. Antiv. Res. 20: 185-192.
30. Young J, Wahle KW, Boyle SP (2007). Cytoprotective effects of phenolic antioxidants And essential fatty acids in human blood monocyte and neuroblastoma cell lines: surrogates for neurological damage in vivo. Prostagl. Leukotr. Essent. Fat. Acid. 78: 45-59.
31. Yusup A, Upur H, Baudrimont I, Umar A, Kader T, Begaud B, Creppy EE, Moore N (2005). Cytotoxicity of abnormal Savda munziq aqueous extract in human hepatoma(HepG2) cells. Fund. Clin. Pharmacol. 19: 465-472.
32. World Health Organization. Promoting the Role of Traditional Medicine in Health Systems: a strategy for the African Region 2001-2010. Harare, World Health Organization, 2000 (document reference AFR/RC50/Doc.9/R).