Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death

British Journal of Pharmacology

Volumn 158, Issue 4, 2009, Pages 1121-1130

  Perez Alvarez, Sergio ^b   Solesio, Maria E ^a   Manzanares, Jorge ^c   Jordán, Joaquín ^b   Galindo, María F ^a  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALBACETE   (Spain)

^b UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^c MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Bax; Glutathione; Mitochondria; Parkinson's disease; Proteasome; Reactive oxygen species

Indexed keywords

CYTOCHROME C; GLUTATHIONE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LACTACYSTIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOGEN ACTIVATED PROTEIN KINASE P38; OXIDOPAMINE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SCAVENGER;

APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENZYME RELEASE; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ACETYLCYSTEINE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; COLORING AGENTS; CYTOCHROMES C; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GREEN FLUORESCENT PROTEINS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; NEUROBLASTOMA; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 70350130100     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00388.x     Document Type: Article

References (32)

1. Alam ZI, Daniel SE, Lees AJ, Marsden DC, Jenner P, Halliwell B (1997). A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J Neurochem 69 : 1326 1329.
2. Canu N, Barbato C, Ciotti MT, Serafino A, Dus L, Calissano P (2000). Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. J Neurosci 20 : 589 599.
3. De CG, Marcocci ME, Torcia M, Lucibello M, Rosini P, Bonini P et al. (2006). Bcl-2 phosphorylation by p38 MAPK: identification of target sites and biologic consequences. J Biol Chem 281 : 21353 21361.
4. Favit A, Grimaldi M, Alkon DL (2000). Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytic pathway. J Neurochem 75 : 1258 1263.
5. Fenteany G, Standaert RF, Reichard GA, Corey EJ, Schreiber SL (1994). A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci USA 91 : 3358 3362.
6. Fernandez-Gomez FJ, Galindo MF, Gómez-Lázaro M, Yuste VJ, Comella JX, Aguirre N et al. (2005). Malonate induces cell death via mitochondrial potential collapse and delayed swelling through an ROS-dependent pathway. Br J Pharmacol 144 : 528 537.
7. Figueiredo-Pereira ME, Berg KA, Wilk S (1994). A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell. J Neurochem 63 : 1578 1581.
8. Forman MS, Trojanowski JQ, Lee VM (2004). Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat Med 10 : 1055 1063.
9. Forno LS (1996). Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 55 : 259 272.
10. Galindo MF, Jordan J, Gonzalez-Garcia C, Cena V (2003a). Chromaffin cell death induced by 6-hydroxydopamine is independent of mitochondrial swelling and caspase activation. J Neurochem 84 : 1066 1073.
11. Galindo MF, Jordan J, Gonzalez-Garcia C, Ceña V (2003b). Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria. Br J Pharmacol 139 : 797 804.
12. Gomez-Lazaro M, Galindo MF, Melero-Fernandez de Mera RM, Fernandez-Gomez FJ, Concannon CG, Segura MF et al. (2007). Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. Mol Pharmacol 71 : 736 743.
13. Gomez-Lazaro M, Galindo MF, Concannon CG, Segura MF, Fernandez-Gomez FJ, Llecha N et al. (2008). 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J Neurochem 104 : 1599 1612.
14. Jenner P (1993). Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. Acta Neurol Scand Suppl 146 : 6 13.
15. Jordan J, Galindo MF, Tornero D, Gonzalez-Garcia C, Cena V (2004). Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells. J Neurochem 89 : 124 133.
16. Lang-Rollin I, Vekrellis K, Wang Q, Rideout HJ, Stefanis L (2004). Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway. J Neurochem 90 : 1511 1520.
17. Lang-Rollin I, Maniati M, Jabado O, Vekrellis K, Papantonis S, Rideout HJ et al. (2005). Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2. Apoptosis 10 : 809 820.
18. Lang-Rollin I, Dermentzaki G, Vekrellis K, Xilouri M, Rideout HJ, Stefanis L (2008). A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons. J Neurochem 105 : 653 665.
19. Lee CS, Park WJ, Ko HH, Han ES (2006). Differential involvement of mitochondrial permeability transition in cytotoxicity of 1-methyl-4- phenylpyridinium and 6-hydroxydopamine. Mol Cell Biochem 289 : 193 200.
20. Lev N, Melamed E, Offen D (2006). Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage. Neurosci Lett 399 : 27 32.
21. McNaught KS, Jenner P (2001). Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci Lett 297 : 191 194.
22. McNaught KS, Olanow CW (2006). Proteasome inhibitor-induced model of Parkinson's disease. Ann Neurol 60 : 243 247.
23. McNaught KS, Belizaire R, Jenner P, Olanow CW, Isacson O (2002). Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease. Neurosci Lett 326 : 155 158.
24. Martinou JC, Green DR (2001). Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2 : 63 67.
25. Offen D, Gorodin S, Melamed E, Hanania J, Malik Z (1999). Dopamine-melanin is actively phagocytized by PC12 cells and cerebellar granular cells: possible implications for the etiology of Parkinson's disease. Neurosci Lett 260 : 101 104.
26. Piccioli P, Porcile C, Stanzione S, Bisaglia M, Bajetto A, Bonavia R et al. (2001). Inhibition of nuclear factor-kappaB activation induces apoptosis in cerebellar granule cells. J Neurosci Res 66 : 1064 1073.
27. Qiu JH, Asai A, Chi S, Saito N, Hamada H, Kirino T (2000). Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons. J Neurosci 20 : 259 265.
28. Sadoul R, Fernandez PA, Quiquerez AL, Martinou I, Maki M, Schroter M et al. (1996). Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons. EMBO J 15 : 3845 3852.
29. Shrieve DC, Bump EA, Rice GC (1998). Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis. J Biol Chem 263 : 14107 14114.
30. Suh J, Lee YA, Gwag BJ (2005). Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures. J Neurochem 95 : 684 694.
31. Winklhofer KF, Tatzelt J, Haass C (2008). The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J 27 : 336 349.
32. Young PR, Connor S, White AL, Dzido GA (1994). Kinetic analysis of the intracellular conjugation of monochlorobimane by IC-21 murine macrophage glutathione-S-transferase. Biochim Biophys Acta 1201 : 461 465.