Adjustment of treatment increases quality of life in patients with epilepsy: A randomized controlled pragmatic trial

European Journal of Neurology

Volumn 16, Issue 11, 2009, Pages 1173-1177

  Uijl, S G ^a   Uiterwaal, C S P M ^a   Aldenkamp, A P ^b   Carpay, J A ^c   Doelman, J C ^d   Keizer, K ^e   Vecht, C J ^f   De Krom, M C T F M ^b   Van Donselaar, C A ^g  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Tergooi Hospitals   (Netherlands)

^d Oosterschelde Hospital   (Netherlands)

^e CATHARINA HOSPITAL   (Netherlands)

^f MEDICAL CENTER HAAGLANDEN   (Netherlands)

^g Maasstad Hospital Rotterdam   (Netherlands)

Author keywords

Adult; Adverse effects; Antiepileptic drugs; Epilepsy; Pragmatic trial; Quality of life; Randomized clinical trial

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; LAMOTRIGINE; OXCARBAZEPINE; PHENYTOIN; VALPROIC ACID;

ADULT; ANTICONVULSANT THERAPY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG FORMULATION; DRUG WITHDRAWAL; EPILEPSY; FEMALE; FOLLOW UP; GENERAL HOSPITAL; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; RISK ASSESSMENT; SCORING SYSTEM; SEIZURE; SLOW RELEASE FORMULATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADULT; ANTICONVULSANTS; DRUG ADMINISTRATION SCHEDULE; EPILEPSY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PATIENT SATISFACTION; QUALITY OF LIFE; QUESTIONNAIRES; SEIZURES; TREATMENT OUTCOME;

EID: 70350127986     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02713.x     Document Type: Article

References (12)

1. Carpay JA, Aldenkamp AP, van Donselaar CA. Complaints associated with the use of antiepileptic drugs: results from a community-based study. Seizure 2005 14 : 198 206.
2. Deckers CL, Hekster YA, Keyser A, Lammers MW, Meinardi H, Renier WO. Adverse effects in epilepsy therapy. Wait and see or go for it? Acta Neurol Scand 1997 95 : 248 252.
3. Gilliam FG, Fessler AJ, Baker G, Vahle V, Carter J, Attarian H. Systematic screening allows reduction of adverse antiepileptic drug effects: a randomized trial. Neurology 2004 62 : 23 27.
4. Langfitt J, Meador K. Want to improve epilepsy care? Ask the patient. Neurology 2004 62 : 6 7.
5. Uijl SG, Uiterwaal CS, Aldenkamp AP, et al. A cross-sectional study of subjective complaints in patients with epilepsy who seem to be well-controlled with anti-epileptic drugs. Seizure 2006 15 : 242 248.
6. Arrindell WA, Ettema JHM. SCL-90: Manual for a Multidimensional Indicator of Psycho-Pathology [In Dutch: SCL-90: handleiding bij een multidimensionele psychopathologie-indicator]. Lisse : Swets & Zeitlinger B.V., 1986.
7. Derogatis LR, Lipman RS, Covi L. SCL-90, an outpatient psychiatric rating scale. Psychopharmacol Bull 1973 9 : 13 28.
8. Cramer JA, Perrine K, Devinsky O, Meador K. A brief questionnaire to screen for quality of life in epilepsy: the QOLIE-10. Epilepsia 1996 37 : 577 582.
9. Cohen J. Statistical Power Analysis for the Behavioral Sciences. New York : Academic Press, 1977.
10. French J. The long-term therapeutic management of epilepsy. Ann Intern Med 1994 120 : 411 422.
11. Hotopf M. The pragmatic randomised controlled trial. Adv Psychiatr Treat 2002 8 : 326 333.
12. Roland M, Torgerson DJ. What are pragmatic trials? BMJ 1998 316 : 285.