Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart

Biochemical Journal

Volumn 423, Issue 3, 2009, Pages 421-428

  Korzeniewski, Bernard ^a,b   Deschodt Arsac, Véronique ^b   Calmettes, Guillaume ^b   Gouspillou, Gilles ^b   Franconi, Jean Michel ^b   Diolez, Philippe ^b  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b CNRS University Bordeaux Segalen   (France)

Author keywords

Heart; Metabolic regulation; Oxidative phosphorylation; Perfusion; Proportional Activation Approach (PAA); Respiratory substrate

Indexed keywords

CHEMICAL ACTIVATION; CHROMIUM COMPOUNDS; ECONOMICS; HEART; INSULIN; PHOSPHORYLATION; RATS; SUBSTRATES;

ACTIVATION APPROACHES; METABOLIC REGULATIONS; OXIDATIVE PHOSPHORYLATION; PERFUSION; RESPIRATORY SUBSTRATES;

GLUCOSE;

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; INSULIN; LACTIC ACID; PYRUVIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CELL KINETICS; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HEART PERFUSION; HEART RATE VARIABILITY; HEART VENTRICLE PRESSURE; NONHUMAN; OXIDATION; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT;

RATTUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; LACTIC ACID; MALE; MYOCARDIUM; PERFUSION; PHOSPHOCREATINE; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SWEETENING AGENTS;

EID: 70350122101     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090395     Document Type: Article

References (15)

1. 31P-NMR studies of respiratory regulation in the intact myocardium. FEBS Lett. 206, 257-261
2. From, A. H. L., Zimmer, S. D., Michurski, S. P., Mohanakrishnan, P., Ulstad, V. K., Thoma, W. J. and Ugurbil, K. (1990) Regulation of the oxidative phosphorylation rate in the intact cell. Biochemistry 29, 3731-3743
3. Zweier, J. L. and Jacobus, W. E. (1987) Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart. J. Biol. Chem. 262, 8015-8021
4. Kobayashi, K. and Neely, J. R. (1979) Control of maximum rates of glycolysis in rat cardiac muscle. Circ. Res. 44, 166-175
5. Diolez, P., Descholdt-Arsac, V., Raffard, G., Simon, C., Dos Santos, P., Thiaudiere, E., Arsac, L. and Franconi, J.-M. (2007) Modular regulation analysis of heart contraction: application to in situ demonstration of a direct mitochondrial activation by calcium in beating heart. Am. J. Physiol. 293, R13-R19
6. Diolez, P., Raffard, G., Simon, C., Leducq, N., Dos Santos, P. and Canioni, P. (2002) Mitochondria do not control heart bioenergetics. Mol. Biol. Rep. 29, 193-196
7. Kashiwaya, Y., Sato, K., Tsuchiya, N., Thomas, S., Fell, D. A., Veech, R. L. and Passonneau, J. V. (1994) Control of glucose utilization in working perfused rat heart. J. Biol. Chem. 269, 25502-25514
8. Sharma, N., Okere, I. C., Brunengraber, D. Z., McElfresh, T. A., King, K. L., Sterk, J. P., Huang, H., Chandler, M. P. and Stanley, W. C. (2005) Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation. J. Physiol. 562, 593-603
9. Korzeniewski, B., Harper, M.-E. and Brand, M. D. (1995) Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or by vasopressin. Biochim. Biophys. Acta 1229, 315-322
10. Korzeniewski, B., Deschodt-Arsac, V., Calmettes, G., Franconi, J.-M. and Diolez, P. (2008) Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply. Biochem. J. 413, 343-347
11. Dos Santos, P., Aliev, M. K., Diolez, P., Duclos, F., Besse, P., Bonoron-Adele, S., Sikk, P., Canioni, P. and Saks, V. A. (2000) Metabolic control of contractile performance in isolated perfused rat heart. Analysis of experimental data by reaction:diffusion mathematical model. J. Mol. Cell. Cardiol. 32, 1703-1734
12. Fell, D. A. (1992) Metabolic Control Analysis: a survey of its theoretical and experimental development. Biochem. J. 286, 313-330
13. Korzeniewski, B., Noma, A. and Matsuoka, S. (2005) Regulation of oxidative phosphorylation in intact mammalian heart in vivo. Biophys. Chem. 116, 145-157
14. Buttgereit, F. and Brand, M. D. (1995) A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312, 163-167
15. Jeffrey, F. M. and Malloy, C. R. (1992) Respiratory control and substrate effects in the working rat heart. Biochem. J. 287, 117-123