Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis

Pigment Cell and Melanoma Research

Volumn 22, Issue 6, 2009, Pages 799-808

  Shah, Meera ^a   Stebbins, John L ^a   Dewing, Antimone ^a   Qi, Jianfei ^a   Pellecchia, Maurizio ^a   Ronai, Ze'Ev A ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Hypoxia; Melanoma; Meso scale; Ras; Siah2; Ubiquitin ligase

Indexed keywords

AC 0223; ID 01500450; ID 01500618; LIGASE INHIBITOR; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; SPROUTY PROTEIN; ST 066885; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HIF 1ALPHA; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE E3 SIAH 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPOXIA; MALE; MELANOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; XENOGRAFT;

ANIMALS; ANOXIA; BIOLOGICAL ASSAY; CELL LINE; ENZYME INHIBITORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MELANOMA; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS; UBIQUITIN-PROTEIN LIGASES; VITAMIN K 3; VITAMINS;

EID: 70350116000     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2009.00628.x     Document Type: Article

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