Functional Variants in ADH1B and ALDH2 Coupled With Alcohol and Smoking Synergistically Enhance Esophageal Cancer Risk

Gastroenterology

Volumn 137, Issue 5, 2009, Pages 1768-1775

  Cui, Ri ^a   Kamatani, Yoichiro ^a   Takahashi, Atsushi ^b   Usami, Masayuki ^a   Hosono, Naoya ^b   Kawaguchi, Takahisa ^b   Tsunoda, Tatsuhiko ^b   Kamatani, Naoyuki ^b   Kubo, Michiaki ^b   Nakamura, Yusuke ^a,b   Matsuda, Koichi ^a  

^a THE UNIVERSITY OF TOKYO   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1B; ALDEHYDE DEHYDROGENASE ISOENZYME 2; UNCLASSIFIED DRUG;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CHROMOSOME 12Q; CHROMOSOME 4Q; CONTROLLED STUDY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENE STRUCTURE; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN GENOME; JAPANESE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING;

AGED; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; ESOPHAGEAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SMOKING;

EID: 70350102890     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.07.070     Document Type: Article

References (40)

1. Parkin D.M., Bray F., Ferlay J., et al. Global cancer statistics, 2002. CA Cancer J Clin 55 (2005) 74-108
2. Tamoto E., Tada M., Murakawa K., et al. Gene-expression profile changes correlated with tumor progression and lymph node metastasis in esophageal cancer. Clin Cancer Res 10 (2004) 3629-3638
3. Coleman M.P., Gatta G., Verdecchia A., et al. EUROCARE-3 summary: cancer survival in Europe at the end of the 20th century. Ann Oncol 14 Suppl 5 (2003) v128-v149
4. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2008. CA Cancer J Clin 58 (2008) 71-96
5. Yang L., Parkin D.M., Li L., et al. Time trends in cancer mortality in China: 1987-1999. Int J Cancer 106 (2003) 771-783
6. Franceschi S., Bidoli E., Negri E., et al. Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. Int J Cancer 86 (2000) 626-631
7. Hu N., Wang C., Hu Y., et al. Genome-wide association study in esophageal cancer using GeneChip mapping 10K array. Cancer Res 65 (2005) 2542-2546
8. Wu M.T., Lee J.M., Wu D.C., et al. Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan. Br J Cancer 87 (2002) 529-532
9. Yokoyama A., Muramatsu T., Omori T., et al. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis 22 (2001) 433-439
10. Nakamura Y. The BioBank Japan Project. Clin Adv Hematol Oncol 5 (2007) 696-697
11. Satagopan J.M., Verbel D.A., Venkatraman E.S., et al. Two-stage designs for gene-disease association studies. Biometrics 58 (2002) 163-170
12. Skol A.D., Scott L.J., Abecasis G.R., et al. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 38 (2006) 209-213
13. Ohnishi Y., Tanaka T., Ozaki K., et al. A high-throughput SNP typing system for genome-wide association studies. J Hum Genet 46 (2001) 471-477
14. Price A.L., Patterson N.J., Plenge R.M., et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38 (2006) 904-909
15. Yokoyama A., Kato H., Yokoyama T., et al. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis 23 (2002) 1851-1859
16. Hashibe M., McKay J.D., Curado M.P., et al. Multiple ADH genes are associated with upper aerodigestive cancers. Nat Genet 40 (2008) 707-709
17. Yin S.J., Bosron W.F., Li T.K., et al. Polymorphism of human liver alcohol dehydrogenase: identification of ADH2 2-1 and ADH2 2-2 phenotypes in the Japanese by isoelectric focusing. Biochem Genet 22 (1984) 169-180
18. Bosron W.F., and Li T.K. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 6 (1986) 502-510
19. Yoshida A., Hsu L.C., and Yasunami M. Genetics of human alcohol-metabolizing enzymes. Prog Nucleic Acid Res Mol Biol 40 (1991) 255-287
20. Harada S., Agarwal D.P., Goedde H.W., et al. Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet 2 (1982) 827
21. Hiyama T., Yoshihara M., Tanaka S., et al. Genetic polymorphisms and esophageal cancer risk. Int J Cancer 121 (2007) 1643-1658
22. Kensler C.J., and Battista S.P. Components of cigarette smoke with ciliary-depressant activity. Their selective removal by filters containing activated charcoal granules. N Engl J Med 269 (1963) 1161-1166
23. Seitz H.K., and Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7 (2007) 599-612
24. Boyle P., Autier P., Bartelink H., et al. European Code Against Cancer and scientific justification: third version (2003). Ann Oncol 14 (2003) 973-1005
25. Woutersen R.A., Appelman L.M., Van Garderen-Hoetmer A., et al. Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study. Toxicology 41 (1986) 213-231
26. Feron V.J., Kruysse A., and Woutersen R.A. Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine. Eur J Cancer Clin Oncol 18 (1982) 13-31
27. Yokoyama A., Tsutsumi E., Imazeki H., et al. Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. Alcohol Clin Exp Res 32 (2008) 1607-1614
28. Otsuka M., Harada N., Itabashi T., et al. Blood and urinary levels of ethanol, acetaldehyde, and C4 compounds such as diacetyl, acetoin, and 2,3-butanediol in normal male students after ethanol ingestion. Alcohol 17 (1999) 119-124
29. Hecht S.S. Metabolic activation and detoxification of tobacco-specific nitrosamines-a model for cancer prevention strategies. Drug Metab Rev 26 (1994) 373-390
30. Hoffmann D., and Hecht S.S. Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions. Cancer Res 45 (1985) 935-944
31. Takeshita T., Mao X.Q., and Morimoto K. The contribution of polymorphism in the alcohol dehydrogenase beta subunit to alcohol sensitivity in a Japanese population. Hum Genet 97 (1996) 409-413
32. Yokoyama A., Muramatsu T., Omori T., et al. Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics. Alcohol Clin Exp Res 23 (1999) 1705-1710
33. Higuchi S., Matsushita S., Murayama M., et al. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatry 152 (1995) 1219-1221
34. Luczak S.E., Wall T.L., Shea S.H., et al. Binge drinking in Chinese, Korean, and White college students: genetic and ethnic group differences. Psychol Addict Behav 15 (2001) 306-309
35. Lee C.H., Lee J.M., Wu D.C., et al. Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. Int J Cancer 122 (2008) 1347-1356
36. Guo Y.M., Wang Q., Liu Y.Z., et al. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. World J Gastroenterol 14 (2008) 1444-1449
37. Chen Y.J., Chen C., Wu D.C., et al. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. Int J Cancer 119 (2006) 2827-2831
38. Yokoyama A., and Omori T. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers. Jpn J Clin Oncol 33 (2003) 111-121
39. Innocenti F., and Ratain M.J. Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping. Pharmacogenomics 7 (2006) 1211-1221
40. Mushiroda T., Ohnishi Y., Saito S., et al. Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients. J Hum Genet 51 (2006) 249-253