Brainstem oxytocinergic modulation of heart rate control in rats: Effects of hypertension and exercise training: Experimental Physiology

Experimental Physiology

Volumn 94, Issue 11, 2009, Pages 1103-1113

  Higa Taniguchi, Keila T ^a   Felix, Jorge V C ^a   Michelini, Lisete C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN; OXYTOCIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN STEM; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; EXERCISE; HEART RATE; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYTOCIN RELEASE; RAT; RAT STRAIN; RECEPTOR BLOCKING; SOLITARY TRACT NUCLEUS;

EID: 70350092509     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2009.049262     Document Type: Article

References (47)

1. Amaral SL, Silveira NP, Zorn TMT Michelini LC (2001). Exercise training causes skeletal muscle venular growth and alters hemodynamic responses in spontaneously hypertensive rats. J Hypertens 19, 931 940.
2. Amaral SL, Zorn TMT Michelini LC (2000). Exercise training normalizes wall-to-lumen ratio of the gracilis muscle arterioles and reduces pressure in spontaneously hypertensive rats. J Hypertens 18, 1563 1572
3. American College of Sports Medicine (2004). Position stand: exercise and hypertension. Med Sci Sports Exerc 36, 533 553.
4. Braga DC, Mori E, Higa KT, Morris M Michelini LC (2000). Central oxytocin modulates exercise-induced tachycardia. Am J Physiol Regul Integr Comp Physiol 278, R1474 R1482.
5. Brittis PA, Lu Q Flanagan JC (2002). Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell 110, 223 235.
6. Buijs RM (1978). Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to limbic system, medulla oblongata and spinal cord. Cell Tissue Res 192, 423 435.
7. Charpak S, Armstrong WE, Muhlethaler M Dreifuss JJ (1984). Stimulatory action of oxytocin on neurons of the dorsal motor nucleus of the vagus nerve. Brain Res 300, 83 89.
8. Clausen JP (1977). Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev 57, 779 815.
9. Collins HL, Rodenbaugh DW DiCarlo SE (2000). Daily exercise attenuated the sympathetic component of the spontaneous arterial baroreflex control of heart rate in hypertensive rats. Clin Exp Hypertens 22, 607 622.
10. Crino PB Eberwine J (1996). Molecular characterization of the dendritic growth cone: regulated mRNA transport and local protein synthesis. Neuron 17, 1173 1187.
11. Dreifuss JJ, Raggenbass M, Charpak S, Dubois-Dauphin M Tribollet E (1988). A role of central oxytocin in autonomic functions: its action in the motor nucleus of the vagus nerve. Brain Res Bull 20, 765 770.
12. Felix JVC Michelini LC (2007). Training-induced pressure fall in spontaneously hypertensive rats is associated with reduced angiotensinogen mRNA expression within the nucleus tractus solitarii. Hypertension 50, 780 785.
13. Folkow B Hallbäck MIL (1977). Physiopathology of spontaneous hypertension in rats. In Hypertension, ed. Genest J, Koiw E & Kuchel O, pp. 507 529. McGraw-Hill, New York.
14. Higa KT, Mori E, Viana FF, Morris M Michelini LC (2002). Baroreflex control of heart rate by oxytocin in the solitary-vagal complex. Am J Physiol Regul Integr Comp Physiol 282, R537 R545.
15. Higa-Taniguchi KT, Silva FCP, Silva HMV, Michelini LC Stern JE (2007). Exercise training-induced remodeling of paraventricular nucleus (nor)adrenergic innervation in normotensive and hypertensive rats. Am J Physiol Regul Integr Comp Physiol 292, R1717 R1727.
16. Hudlicka O, Brown MD Eggiton S (1992). Angiogenesis in skeletal and cardiac muscle. Physiol Rev 72, 369 417.
17. Jackson K, Silva HMV, Zhang W, Michelini LC Stern JE (2005). Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus. J Neurophysiol 94, 3211 3220.
18. Key M, Wirick B, Cool D Morris M (2001). Quantitative in situ hybridization for peptide mRNAs in mouse brain. Brain Res Brain Res Protoc 8, 8 15.
19. Laughlin MH (1995). Endothelium-mediated control of coronary vascular tone after chronic exercise training. Med Sci Sports Exerc 27, 1135 1144.
20. McKinley MJ, Albiston AL, Allen AM, Mathai CN, May CN, McAllen RM, Oldfield BJ, Mendelsohn FAO Chai SY (2003). The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol 35, 901 918.
21. Martins AS, Crescenzi A, Stern JE, Bordin S Michelini LC (2005). Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain. Hypertension 46, 1004 1009.
22. Melo RM, Martinho Jr. E Michelini LC (2003). Training-induced, pressure-lowering effect in SHR: wide effects on circulatory profile of exercised and nonexercised muscles. Hypertension 42, 851 857.
23. Michelini LC (2001). Oxytocin in the NTS: a new modulator of cardiovascular control during exercise. Ann N Y Acad Sci 940, 206 220.
24. Michelini LC (2007a). Differential effects of vasopressinergic and oxytocinergic pre-autonomic neurons on circulatory control: reflex mechanisms and changes during exercise. Clin Exp Pharmacol Physiol 34, 369 376.
25. Michelini LC (2007b). The NTS and the integration of cardiovascular control during exercise in normotensive and hypertensive individuals. Curr Hypertens Rep 9, 214 221.
26. Mohr E Richter D (2000). Axonal mRNAs: functional significance in vertebrates and invertebrates. J Neurocytol 29, 787 795.
27. Mohr E Richter D (2003). Molecular determinants and physiological relevance of extrasomic RNA localization in neurons. Front Neuroendocrinol 24, 128 139.
28. Mueller PJ (2007). Exercise training attenuates increases in the lumbar sympathetic nerve activity produced by stimulation of the rostral ventrolateral medulla. J Appl Physiol 102, 803 813.
29. Negrao CE, Irigoyen MC, Moreira ED, Brum PC, Freire PM Krieger EM (1993). Effects of exercise training on RSNA, baroreflex control and blood pressure responsiveness. Am J Physiol Heart Circ Physiol 265, H365 H370.
30. Negrao CE, Moreira ED, Brum PC, Denadai MLDR Krieger EM (1992a). Vagal and sympathetic control of heart rate during exercise by sedentary and exercise-trained rats. Braz J Med Biol Res 25, 1045 1052.
31. Negrao CE, Moreira ED, Santos MCLM, Farah VMA Krieger EM (1992b). Vagal function impairment after exercise training. J Appl Physiol 72, 1749 1753.
32. Paul M, Mehr AP Kreutz R (2006). Physiology of local renin-angiotensin systems. Physiol Rev 86, 747 803.
33. Paxinos G Watson C (1986). The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic Press, San Diego.
34. Peters JH, McDougall SJ, Kellett DO, Jordan D, Llewellyn-Smith IJ Andresen MC (2008). Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus. J Neurosci 28, 11731 11740.
35. Petersson M, Lundeberg T Uvnas-Moberg K (1999). Short-term increase and long-term decrease of blood pressure in response to oxytocin-potentiating effect of female steroid hormones. J Cardiovasc Pharmacol 33, 102 108.
36. Potts JT (2006). Inhibitory neurotransmission in the nucleus tractus solitarii: implications for baroreflex resetting during exercise. Exp Physiol 91, 59 72.
37. Prior BM, Yang HT Terjung RL (2004). What makes vessels grow with exercise training? J Appl Physiol 97, 1119 1128.
38. Raven PB, Fadel PJ Ogoh S (2006). Arterial baroreflex resetting during exercise: a current perspective. Exp Physiol 91, 37 49.
39. Rozen F, Russo C, Banville D Zingg HH (1995). Structure, characterization and expression of the rat oxytocin receptor gene. Proc Natl Acad Sci USA 92, 200 204.
40. Russ RD Walter BR (1994). Oxytocin augments baroreflex bradycardia in conscious rats. Peptides 15, 907 912.
41. Sawchenko PE Swanson LW (1982). Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J Comp Neurol 205, 260 272.
42. Scheuer J Tipton CM (1977). Cardiovascular adaptations to physical training. Ann Rev Physiol 39, 221 251.
43. Schmitz E, Mohr E Richter D (1991). Rat vasopressin and oxytocin genes are linked by a long interspersed repeat DNA element (LINE): sequence and transcriptional analysis of LINE. DNA Cell Biol 10, 81 91.
44. Smith ML, Hudson DL, Graitzer HM Raven PB (1989). Exercise training bradycardia: the role of autonomic balance. Med Sci Sports Exerc 21, 40 44.
45. Sofroniew MV Schrell U (1981). Evidence for a direct projection from oxytocin and vasopressin neurons in the hypothalamic paraventricular nucleus to the medulla oblongata: immunohistochemical visualization of both the horseradish peroxidase transported and the peptide produced by the same neuron. Neurosci Lett 22, 211 217.
46. Verbalis JG, Mangione MP Stricker EM (1991). Oxytocin produces natriuresis in rats at physiological plasma concentrations. Endocrinology 128, 1317 1322.
47. Waldrop TG, Eldridge FL, Iwamoto GA Mitchell JH (1996). Central neural control of respiration and circulation during exercise. In Handbook of Physiology, section 12, Exercise, Regulation and Integration of Multiple Systems, ed. Rowell LB & Shepherd JT, pp. 333 380. Oxford University Press, New York.