Overexpression of Plk3 causes morphological change and cell growth suppression in ras pathway-activated cells

Journal of Biochemistry

Volumn 146, Issue 4, 2009, Pages 501-507

  Iida, Masato ^a   Sasaki, Takanori ^a   Komatani, Hideya ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Growth suppression; H Ras; Morphology; Overexpression; Plk3

Indexed keywords

F ACTIN; POLO LIKE KINASE 3; RAS PROTEIN;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL ASSAY; CELL GROWTH; CELL STRAIN; CELL STRUCTURE; CELL TRANSFORMATION; CELL ULTRASTRUCTURE; COLONY FORMATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

ANIMALS; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; CYTOSKELETON; GENE EXPRESSION; HUMANS; MICE; NIH 3T3 CELLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 70350077987     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvp092     Document Type: Article

References (18)

1. Pawlak, G. and Helfman, D.M. (2001) Cytoskeletal changes in cell transformation and tumorigenesis. Curr. Opin. Genet. Dev. 11, 41-47
2. Gluck, U., Kwiatkowski, D.J., and Ben-Ze'ev, A. (1993) Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with alpha-actinin cDNA. Proc. Natl Acad. Sci. USA 90, 383-387
3. Prasad, G.L., Fuldner, R.A., and Cooper, H.L. (1993) Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene. Proc. Natl Acad. Sci. USA 90, 7039-7043
4. Sahai, E., Olson, M.F., and Marshall, C.J. (2001) Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 20, 755-766
5. Pawlak, G. and Helfman, D.M. (2002) Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEKdependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Mol. Biol. Cell 13, 336-347
6. Lee, S. and Helfman, D.M. (2004) Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/ cofilin pathway. J. Biol. Chem. 279, 1885-1891
7. Holtrich, U., Wolf, G., Yuan, J., Bereiter-Hahn, J., Karn, T., Weiler, M., Kauselmann, G., Rehli, M., Andreesen, R., Kaufmann, M., Kuhl, D., and Strebhardt, K. (2000) Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. Oncogene 19, 4832-4839
8. Xie, S., Wang, Q., Ruan, Q., Liu, T., Jhanwar-Uniyal, M., Guan, K., and Dai, W. (2004) MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3. Oncogene 23, 3822-3829
9. Xie, S., Wang, Q., Wu, H., Cogswell, J., Lu, L., Jhanwar- Uniyal, M., and Dai, W. (2001) Reactive oxygen speciesinduced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J. Biol. Chem. 276, 36194-36199
10. Xie, S., Wu, H., Wang, Q., Cogswell, J.P., Husain, I., Conn, C., Stambrook, P., Jhanwar-Uniyal, M., and Dai, W. (2001) Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J. Biol. Chem. 276, 43305-43312
11. Li, Z., Niu, J., Uwagawa, T., Peng, B., and Chiao, P.J. (2005) Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response. J. Biol. Chem. 280, 16843-16850
12. Duan, H., Orth, K., Chinnaiyan, A.M., Poirier, G.G., Froelich, C.J., He, W.W., and Dixit, V.M. (1996) ICELAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271, 16720-16724
13. Chan, A.Y., Bailly, M., Zebda, N., Segall, J.E., and Cndeelis, J.S. (2000) Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion. J. Cell Biol. 48, 531-542
14. Yang, N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E., and Mizuno, K. (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Racmediated actin reorganization. Nature 393, 809-812
15. Wang, W.J., Kuo, J.C., Yao, C.C., and Chen, R.H. (2002) DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J. Cell Biol. 159, 169-179
16. Raveh, T., Droguett, G., Horwitz, M.S., DePinho, R.A., and Kimchi, A. (2001) DAP kinase activates a p19ARF/p53- mediated apoptotic checkpoint to suppress oncogenic transformation. Nat. Cell Biol. 3, 1-7
17. Li, B., Ouyang, B., Pan, H., Reissmann, P.T., Slamon, D.J., Arceci, R., Lu, L., and Dai, W. (1996) Prk, a cytokineinducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. J. Biol. Chem. 271, 19402-19408
18. Dai, W., Li, Y., Ouyang, B., Pan, H., Reissmann, P., Li, J., Wiest, J., Stambrook, P., Gluckman, J.L., Noffsinger, A., and Bejarano, P. (2000) PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer. Genes Chromosomes Cancer 27, 332-336