Antimalarial mixed ligand metal complexes: Synthesis, physicochemical and biological activities

International Journal of Physical Sciences

Volumn 4, Issue 9, 2009, Pages 529-534

  Adediji, J F ^a   Olayinka, E T ^a   Adebayo, M A ^a   Babatunde, O ^a  

^a Ajayi Crowther University   (Nigeria)

Author keywords

Antimalarial mixed metal complexes; Antimicrobial evaluation; Complexation; Toxicological studies

Indexed keywords

EID: 70350063667     PISSN: 19921950     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Akanji MA, Ngaha EO (1989). Effect of repeated administration of Berenil on urinary excretion with corresponding tissue pattern in rats. J. Pharm. Toxicol. 64: 272-275.
2. Akanji MA, Olagoke OA, Oloyede OB (1993). Effects of chronic consuption of metabisulphate on the integrity of the rat kidney cellular system. Toxicology 81: 173-179.
3. Ibrahim SA, Shaker AM, Ismail NM, Mahmoud MR (1995). Mixed-ligands complexes of Ni(ii), Th(iv) and Vo(ii) with some benzoic acid derivatives and amino acids. Chem. Abst. 122: 1028.
4. Laboratories Manual (1997). Randox Enzyme Assay Manual: ACP, ALP, GOT and GPT. Randox Laboratories Ltd, U.K.
5. Lowry OH, Rosebrough NJ, Farr AI, Randall RJ (1951). Protein measurement with folin phenol reagent. J. Biol. Chem. 193: 265-275.
6. Maurya RC, Batalia S (2001). Synthesis and characterisation of some novel mixed-ligand cyanonitrosyl [MnNO]6 complexes of Manga-nese(I) involving multifunctional bioactive donors. Indian J. Chem. 40a(6): 652-655.
7. Mohamed GG, Abdel-Wahab ZH (2005). Mixed ligand complexes of bis (phenylimine) Schiff base ligands incorporating pyridinium moiety: synthesis, characterisation and antibacterial activitity. Spectrochi- mica Acta. Part A: Mole. Biomole. Spect. 9(61): 2231-2238.
8. Moss DW, Rosalki SB (1996). Enzyme Tests in Diagnosis. Edward Arnold. London.
9. Nadira W, Singh HB (1987). Synthesis of metal complexes of antimalaria drugs and in-vitro evaluation of their activity. Inorg. Chim. Acta. 135: 134-137.
10. O'Niel PM, Harrison AC, Storr RC, Hawler SR, Ward SA, Park PB (1994). The effect of fluorine substitution on the activity of Amodaquine. J. Med. Chem. 37:1362-1370.
11. Obaleye JA, Balogun EA, Adeyemi OG (1999). Synthesis and in vitro effect of some metal-drug complexes on malaria parasite. Biokemistri. 9(1): 23-27.
12. Obaleye JA, Famurewa O (1989). Inhibitory effects of some inorganic boron triflouride complexes on some micro-organisms, Bios. Res. Comm. 1: 87-93.
13. Obaleye JA, Nde-aga JB, Balogun EA (1997). Some antimalaria drug metal complexes: synthesis, characterization and their in-vivo evaluation against malaria parasite. Afr. J. Sci. 1:10-12.
14. Ogunniran KO, Ajanaku KO, James OO, Ajani OO, Nwinyi CO, Allansela (2008). Fe(iii) and Co(ii) complexes of mixed antibiotics: synthesis, characterization, antimicrobial potential and their effect on alkaline phosphatase activities of selected rat tissues. Int. J. Phys. Sci. 3(8): 177-182.
15. Wasi N, Singh HB (1987). Synthesis of metal complexes of anti-malaria drugs and in vitro evaluation of their activity against plasmodium falciparum. Inorg. Chim. Acta, 135: 133-137.
16. WHO (2001). Anti-malarial drug combination therapy: Report of a WHO technical consultation: 35.
17. Williams HD, Flemming I (1980). Spectroscopic Methods in Organic Chemistry, 4th ed. McGraw-Hill Book Ltd, London.
18. Wolf A (1986). Clinical significant of increased or elevated serum ALP isoenzymes. Clinics Lab. Med. 6:525-532.
19. Wright PJ, Plummer DT, Leathwood PT (1972). Enzyme in rat urine alkaline phosphatase. Enzymologia, 42: 317-327.55.
20. Yakubu MT, Akanji MA, Oladiji AT (2005). Aphrodisiac potentials of aqueous extract of Fadogia agrestis (Schweinf. Ex Heirn) stem in male albino rats. Asia J. Androl. 7: 399-404.