Study of omeprazole stability in aqueous solution: Influence of cyclodextrins

Journal of Drug Delivery Science and Technology

Volumn 19, Issue 5, 2009, Pages 347-351

  El Badry, M ^a   Taha, E I ^a   Alanazi, F K ^a   Alsarra, I A ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Complex formation; Cyclodextrin derivatives; Degradation; HPLC method; Omeprazole; Stability kinetics

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; DIMETHYL BETA CYCLODEXTRIN; MALTOSYL BETA CYCLODEXTRIN; OMEPRAZOLE; UNCLASSIFIED DRUG;

ARTICLE; DEGRADATION KINETICS; DRUG DEGRADATION; DRUG RETENTION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; PH; TEMPERATURE; THERMOSTABILITY;

EID: 70350056205     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(09)50072-X     Document Type: Article

References (16)

1. Howdern C.W. - Clinical pharmacology of omeprazole. - Clin. Pharmacokinet., 20, 39-49, 1990.
2. Sarisuta N., Tourtip T., Chuarcharoern S. - Chemical stability and mechanism of degradation of omeprazole in solution. - Thai. J. Pharm. Sci., 22, 81-88, 1998.
3. Riedel A., Leopold C.S. - Degradation of omeprazole induced by enteric polymer solutions and aqueous dispersions: HPLC investigation. - Drug Dev. Ind. Pharm., 31, 151-160, 2005. (Pubitemid 40315710)
4. Ahmed S.M., Abdel-Rahman A.A., Saleh S.I., Ahmed M.O. - Comparative dissolution characteristics of bropirimine-B-cyclodextrin inclusion complex and its solid dispersion with PEG 6000. - Int. J. Pharm., 96, 5-11, 1993.
5. Saleh S.I, Abdel-Rahman A.A., Aboutaleb A.E., Nakai Y., Ahmed M.O. - Effect of dimethyl-beta-cyclodextrin on nitrazepam stability. - J. Pharm. Belg., 48, 383-388, 1993.
6. Ahmed S.M. - Effect of cyclodextrins on the chemical stability of S1435, a contraceptive steroid progestin, in aqueous solution. - J. Inclusion Phenom., 27, 1-12, 1997.
7. Uekama K., Otagiri M. - Cyclotextrins in drug carrier systems. - Crit. Rev. Ther. Drug Carrier Syst., 3, 1-40, 1987.
8. Paap C.M., Nahata M.C. - Stability of cefotaxime in two peritoneal dialysis solutions. - Am. J. Hosp. Pharm., 47, 147-150, 1990. (Pubitemid 20137279)
9. Huijuan J., Wei L., Kang Z. - Determination of omeprazole in rat plasma by high-performance liquid chromatography without solvent extraction. - J. Chromatography, 837, 112-115, 2006. (Pubitemid 44208756)
10. Nakai Y., Yamamoto K., Terada K., Horibe H. - Interaction of tri-o-methyl-B-cyclodextrin with drugs. - J. Inc. Phenom., 2, 523-531, 1984.
11. nd ed., John Wiley & Sons Inc., New York, USA, 1965, p. 117.
12. Mathew M., Gupta V., Baily R. E. - Stability of omeprazole solutions at various pH values as determined by high-performance liquid chromatography. - Drug Dev. Ind. Pharm., 21, 965-971, 1995.
13. th ed., Lea and Febiger, Philadelphia, USA, 1993, p. 295.
14. Hirayama F., Kurihara M., Uekama K. - Improving the aqueous stability of prostaglandin E2 and prostaglandin A2 by inclusion complexation with methylated-beta-cyclodextrin.- Chem. Pharm. Bull., 32, 4237-4240, 1984. (Pubitemid 15208378)
15. Loftsson T., Johannesson H.R. - The influence of cyclodextrins on the stability of cephalothin and azteronam in aqueous solution. - Die Pharmazie, 29, 292-293, 1994. (Pubitemid 24119942)
16. Alsarra I.A., Ahmed M.O., EL-Badry M., Alanazi F.K., Al-Mohizea A.M., Ahmed S.M. - Effect of β-cyclodextrin derivatives on the kinetics of degradation of cefotaxime sodium in solution state. - J. Drug Del. Sci. Tech., 17, 353-357, 2007.