GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage

Molecular Nutrition and Food Research

Volumn 53, Issue 10, 2009, Pages 1245-1253

  Petermann, Astrid ^a   Miene, Claudia ^a   Schulz Raffelt, Gabriele ^a   Palige, Katja ^a   Hölzer, Jana ^a   Glei, Michael ^a   Böhmer, Frank D ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Apple polyphenols; Chemoprevention; Cumene hydroperoxide; Genotoxic stress; GSTT2

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CUMENE HYDROPEROXIDE; FLAVONOID; GLUTATHIONE TRANSFERASE; GSTT2 PROTEIN, HUMAN; HYDROGEN PEROXIDE; OXIDIZING AGENT; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOLS; SMALL INTERFERING RNA;

APPLE; ARTICLE; BIOSYNTHESIS; CELL LINE; CELL STRAIN HT29; CHEMISTRY; COLON; COMET ASSAY; DNA DAMAGE; DRUG EFFECT; FRUIT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; INTESTINE MUCOSA; METABOLISM; PROMOTER REGION; REPORTER GENE;

ANTICARCINOGENIC AGENTS; BENZENE DERIVATIVES; CELL LINE; COLON; COMET ASSAY; DNA DAMAGE; FLAVONOIDS; FRUIT; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; GENES, REPORTER; GLUTATHIONE TRANSFERASE; HT29 CELLS; HUMANS; HYDROGEN PEROXIDE; INTESTINAL MUCOSA; MALUS; OXIDANTS; PHENOLS; PLANT EXTRACTS; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING;

ANIMALIA; MALUS X DOMESTICA;

EID: 70350031363     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200900110     Document Type: Article

References (35)

1. Slattery, M. L., Diet, lifestyle, and colon cancer. Semin. Gastrointest. Dis. 2000, 11, 142-146.
2. Steinmetz, K. A., Potter, J. D., Vegetables, fruit, and cancer prevention: a review. J. Am. Diet. Assoc. 1996, 96, 1027-1039.
3. Koushik, A., Hunter, D. J., Spiegelman, D., Beeson, W. L., et al., Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies. J. Natl. Cancer Inst. 2007, 99, 1471-1483.
4. Vrhovsek, U., Rigo, A., Tonon, D., Mattivi, F., Quantitation of polyphenols in different apple varieties. J. Agric. Food Chem. 2004,52,6532-6538.
5. Kahle, K., Kraus, M., Richling, E., Polyphenol profiles of apple juices. Mol. Nutr. Food Res. 2005, 49, 797-806.
6. Barth, S. W., Fahndrich, C., Bub, A., Dietrich, H., et al., Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 2005, 26, 1414-1421.
7. Gosse, F., Guyot, S., Roussi, S., Lobstein, A., et al., Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis 2005, 26, 1291-1295.
8. Schaefer, S., Baum, M., Eisenbrand, G., Janzowski, C., Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines. Mol. Nutr. Food Res. 2006, 50, 413-417.
9. Bellion, P., Hofmann, T., Pool-Zobel, B. L., Will, F., et al., Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2. J. Agric. Food Chem. 2008, 56, 6310-6317.
10. Kern, M., Pahlke, G., Balavenkatraman, K. K., B̈hmer, F. D., et al., Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. J. Agric. Food Chem. 2007, 55, 4999-5006.
11. Veeriah, S., Hofmann, T., Glei, M., Dietrich, H., et al., Apple polyphenols and products formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29). J. Agric. Food Chem. 2007, 55,2892-2900.
12. Balavenkatraman, K. K., Jandt, E., Friedrich, K., Kautenburger, T., et al., DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. Oncogene 2006, 25, 6319-6324.
13. Hayes, J. D., Flanagan, J. U., Jowsey, I. R., Glutathione transferases. Annu. Rev. Pharmacol. Toxicol. 2005, 45, 51-88.
14. Landi, S., Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat. Res 2000, 463, 247-283.
15. Veeriah, S., Kautenburger, T., Habermann, N., Sauer, J., et al., Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics. Mol. Carcinog. 2006, 45, 164-174.
16. Veeriah, S., Balavenkatraman, K. K., B̈hmer, F., Kahle, K., et al., Intervention with cloudy apple juice results in altered biological activities of ileostomy samples collected from individual volunteers. Eur. J. Nutr. 2008, 47, 226-234.
17. Hussey, A. J., Hayes, J. D., Characterization of a human class- Theta glutathione S-transferase with activity towards 1- menaphthyl sulphate. Biochem. J. 1992, 286 (Pt 3), 929-935.
18. Tan, K. L., Board, P. G., Purification and characterization of a recombinant human Theta-class glutathione transferase (GSTT2-2). Biochem. J. 1996, 315 (Pt 3), 727-732.
19. Will, F., Bauckhage, K., Dietrich, H., Apple pomace liquefaction with pectinases and cellulases: analytical data of corresponding juices. Eur. Food Res. 2000, 211, 291-297.
20. Huemmer, W., Dietrich, H., Will, F., Schreier, P., et al., Content and mean polymerization degree of procyanidins in extracts obtained from clear and cloudy apple juices. Biotechnol. J. 2008, 3, 234-243.
21. Fogh, J., Tempe, G., New human tumor cell lines. Human Tumor Cells in Vitro, Plenum Press, New York 1975, pp. 115-159.
22. Guy, C. A., Hoogendoorn, B., Smith, S. K., Coleman, S., et al., Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 2004, 14, 45-51.
23. Dyer, B. W., Ferrer, F. A., Klinedinst, D. K., Rodriguez, R., A noncommercial dual luciferase enzyme assay system for reporter gene analysis. Anal. Biochem. 2000, 282, 158-161.
24. Nourooz-Zadeh, J., Tajaddini-Sarmadi, J., Wolff, S. P., Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal. Biochem. 1994, 220, 403-409.
25. Tice, R. R., Agurell, E., Anderson, D., Burlinson, B., et al., Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35, 206-221.
26. Tan, K. L., Chelvanayagam, G., Parker, M. W., Board, P. G., Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: catalysis with different substrates involves different residues. Biochem. J. 1996, 319 (Pt 1), 315-321.
27. Karagyozov, L., Godfrey, R., Böhmer, S. A., Petermann, A., et al., The structure of the 59-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation. Nucleic Acids Res. 2008, 36, 4443-4453.
28. Lapidot, T., Walker, M. D., Kanner, J., Can apple antioxidants inhibit tumor cell proliferation? Generation of H(2)O(2) during interaction of phenolic compounds with cell culture media. J. Agric. Food Chem. 2002, 50, 3156-3160.
29. Akagawa, M., Shigemitsu, T., Suyama, K., Production of hydrogen peroxide by polyphenols and polyphenol-rich beverages under quasi-physiological conditions. Biosci. Biotechnol. Biochem. 2003, 67, 2632-2640.
30. Gerhäuser, C., Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Med. 2008, 74, 1608-1624.
31. Hiratsuka, A., Kanazawa, M., Nishiyama, T., Okuda, H., et al., A subfamily 2 homo-dimeric glutathione S-transferase mYrs-mYrs of class theta in mouse liver cytosol. Biochem. Biophys. Res. Commun. 1995, 212, 743-750.
32. Hiratsuka, A., Nishijima, T., Okuda, H., Ogura, K., et al., Rat liver theta-class glutathione S-transferases T1-1 and T2-2: their chromatographic, electrophoretic, immunochemical, and functional properties. Anal. Biochem. 1997, 252, 229-237.
33. Pool-Zobel, B. L., Selvaraju, V., Sauer, J., Kautenburger, T., et al., Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics. Carcinogenesis 2005, 26, 1064-1076.
34. Jang, S. G., Kim, I. J., Kang, H. C., Park, H. W., et al., GSTT2 promoter polymorphisms and colorectal cancer risk. BMC Cancer 2007, 7, 16.
35. Kahle, K., Huemmer, W., Kempf, M., Scheppach, W., et al., Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. J. Agric. Food Chem. 2007, 55, 10605-10614.