Differential virulence and innate immune interactions of type I and II fimbrial genotypes of Porphyromonas gingivalis

Oral Microbiology and Immunology

Volumn 24, Issue 6, 2009, Pages 478-484

  Wang, M ^a   Liang, S ^a   Hosur, K B ^a   Domon, H ^a   Yoshimura, F ^b   Amano, A ^c   Hajishengallis, G ^a,d  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d University of Louisville School of Medicine   (United States)

Author keywords

Bone loss; Fimbriae; Inflammation; Macrophages; P. gingivalis; Periodontitis

Indexed keywords

FIMBRIA PROTEIN; PROTEIN FIMBRIAE TYPE 1; PROTEIN FIMBRIAE TYPE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; GENOTYPE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PORPHYROMONAS GINGIVALIS;

ALVEOLAR BONE LOSS; ANIMALS; CELLS, CULTURED; FIMBRIAE PROTEINS; FIMBRIAE, BACTERIAL; IMMUNITY, INNATE; MACROPHAGES; MICE; MICE, INBRED BALB C; PERIODONTITIS; PHAGOCYTOSIS; PORPHYROMONAS GINGIVALIS; VIRULENCE FACTORS;

EID: 70350006685     PISSN: 09020055     EISSN: 1399302X     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2009.00545.x     Document Type: Article

References (38)

1. Amano A. Molecular interaction of Porphyromonas gingivalis with host cells: implication for the microbial pathogenesis of periodontal disease. J Periodontol 2003 : 74 : 90 96.
2. Amano A, Nakagawa I, Kataoka K, Morisaki I, Hamada S. Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients. J Clin Microbiol 1999 : 37 : 1426 1430.
3. Amano A, Nakagawa I, Okahashi N, Hamada N. Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. J Periodontal Res 2004 : 39 : 136 142.
4. Amano A, Sojar HT, Lee JY, Sharma A, Levine MJ, Genco RJ. Salivary receptors for recombinant fimbrillin of Porphyromonas gingivalis. Infect Immun 1994 : 62 : 3372 3380.
5. Baker PJ, Dixon M, Roopenian DC. Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 2000 : 68 : 5864 5868. (Pubitemid 30739376)
6. Bodet C, Chandad F, Grenier D. Porphyromonas gingivalis-induced inflammatory mediator profile in an ex vivo human whole blood model. Clin Exp Immunol 2006 : 143 : 50 57.
7. Enersen M, Olsen I, Kvalheim O, Caugant DA. FimA genotypes and multilocus sequence types of Porphyromonas gingivalis from patients with periodontitis. J Clin Microbiol 2008 : 46 : 31 42.
8. Fujise O, Miura M, Hamachi T, Maeda K. Involvement of Porphyromonas gingivalis fimA genotype in treatment outcome following non-surgical periodontal therapy. J Periodontol 2005 : 76 : 1661 1666.
9. Gibson FC III., Hong C, Chou HH et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004 : 109 : 2801 2806.
10. Graves DT, Fine D, Teng Y-TA, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol 2008 : 35 : 89 105.
11. Hajishengallis G. Peptide mapping of a functionally versatile fimbrial adhesin from Porphyromonas gingivalis. Int J Pept Res Ther 2007 : 13 : 533 546.
12. Hajishengallis G. Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics? Microbes Infect 2009 : 11 : 637 645.
13. Hajishengallis G, Ratti P, Harokopakis E. Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors. J Biol Chem 2005 : 280 : 38902 38913.
14. Hajishengallis G, Shakhatreh M-AK, Wang M, Liang S. Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J Immunol 2007 : 179 : 2359 2367.
15. Hajishengallis G, Tapping RI, Martin MH et al. Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins. Infect Immun 2005 : 73 : 1343 1349.
16. Hajishengallis G, Wang M, Bagby GJ, Nelson S. Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J Immunol 2008 : 181 : 4141 4149.
17. Hajishengallis G, Wang M, Liang S, Triantafilou M, Triantafilou K. Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proc Natl Acad Sci U S A 2008 : 105 : 13532 13537.
18. Holt SC, Ebersole JL. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000 2005 : 38 : 72 122.
19. Inaba H, Nakano K, Kato T et al. Heterogenic virulence and related factors among clinical isolates of Porphyromonas gingivalis with type II fimbriae. Oral Microbiol Immunol 2008 : 23 : 29 35.
20. Jandik KA, Belanger M, Low SL, Dorn BR, Yang MC, Progulske-Fox A. Invasive differences among Porphyromonas gingivalis strains from healthy and diseased periodontal sites. J Periodontal Res 2008 : 43 : 524 530.
21. Kato T, Kawai S, Nakano K et al. Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype. Cell Microbiol 2007 : 9 : 753 765.
22. Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000 1997 : 14 : 33 53.
23. Laine ML, van Winkelhoff AJ. Virulence of six capsular serotypes of Porphyromonas gingivalis in a mouse model. Oral Microbiol Immunol 1998 : 13 : 322 325.
24. Lamont RJ, Jenkinson HF. Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev 1998 : 62 : 1244 1263.
25. Li CH, Amar S. Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model. J Periodontol 2007 : 78 : 1120 1128.
26. Missailidis CG, Umeda JE, Ota-Tsuzuki C, Anzai D, Mayer MP. Distribution of fimA genotypes of Porphyromonas gingivalis in subjects with various periodontal conditions. Oral Microbiol Immunol 2004 : 19 : 224 229.
27. Montminy SW, Khan N, McGrath S et al. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol 2006 : 7 : 1066 1073.
28. Nakagawa I, Amano A, Kuboniwa M, Nakamura T, Kawabata S, Hamada S. Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. Infect Immun 2002 : 70 : 277 285.
29. Nakagawa I, Inaba H, Yamamura T et al. Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Infect Immun 2006 : 74 : 3773 3782.
30. Nakano K, Kuboniwa M, Nakagawa I et al. Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model. Oral Microbiol Immunol 2004 : 19 : 205 209.
31. Nishikawa K, Yoshimura F, Duncan MJ. A regulation cascade controls expression of Porphyromonas gingivalis fimbriae via the FimR response regulator. Mol Microbiol 2004 : 54 : 546 560.
32. Sundqvist G, Figdor D, Hanstrom L, Sorlin S, Sandstrom G. Phagocytosis and virulence of different strains of Porphyromonas gingivalis. Scand J Dent Res 1991 : 99 : 117 129.
33. Wang M, Hajishengallis G. Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages. Cell Microbiol 2008 : 10 : 2029 2042.
34. Wang M, Shakhatreh M-AK, James D et al. Fimbrial proteins of Porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages. J Immunol 2007 : 179 : 2349 2358.
35. Watanabe K, Yamaji Y, Umemoto T. Correlation between cell-adherent activity and surface structure in Porphyromonas gingivalis. Oral Microbiol Immunol 1992 : 7 : 357 363.
36. Yilmaz O, Watanabe K, Lamont RJ. Involvement of integrins in fimbriae-mediated binding and invasion by Porphyromonas gingivalis. Cell Microbiol 2002 : 4 : 305 314.
37. Yoshimura F, Murakami Y, Nishikawa K, Hasegawa Y, Kawaminami S. Surface components of Porphyromonas gingivalis. J Periodontal Res 2008 : 44 : 1 12.
38. Yoshimura F, Takahashi K, Nodasaka Y, Suzuki T. Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis. J Bacteriol 1984 : 160 : 949 957.