Nuclear functions of the influenza A and B viruses NS1 proteins: Do they play a role in viral mRNA export?

Vaccine

Volumn 27, Issue 45, 2009, Pages 6312-6316

  Schneider, Jana ^a   Wolff, Thorsten ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

Author keywords

Influenza virus; mRNA export; NS1 protein

Indexed keywords

MESSENGER RNA; NONSTRUCTURAL PROTEIN 1; PROTEIN TAP; RECEPTOR PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CYTOPLASM; GENETIC TRANSCRIPTION; HOST CELL; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; INFLUENZA VIRUS B; INTRACELLULAR TRANSPORT; MESSENGER RNA SYNTHESIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RNA PROCESSING; RNA SPLICING; RNA TRANSPORT; VIRUS GENOME; VIRUS REPLICATION;

ACTIVE TRANSPORT, CELL NUCLEUS; GENE EXPRESSION REGULATION, VIRAL; INFLUENZA A VIRUS; INFLUENZA B VIRUS; RNA TRANSPORT; RNA, MESSENGER; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 70349976671     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.01.015     Document Type: Article

References (49)

1. Palese P., and Shaw M. Orthomyxoviridae: the viruses and their replication. In: Knipe D.M., and Howley P.M. (Eds). Fields - virology. 5th ed. (2007), Lippincott Williams & Wilkins, Philadelphia 1647-1690
2. Portela A., and Digard P. The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication. J Gen Virol 83 April (Pt 4) (2002) 723-734
3. Reed R., and Hurt E. A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell 108 February (4) (2002) 523-531
4. Luna R., Gaillard H., Gonzalez-Aguilera C., and Aguilera A. Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus. Chromosoma 117 August (4) (2008) 319-331
5. Iglesias N., and Stutz F. Regulation of mRNP dynamics along the export pathway. FEBS Lett 582 June (14) (2008) 1987-1996
6. Kohler A., and Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev 8 October (10) (2007) 761-773
7. Gruter P., Tabernero C., von Kobbe C., Schmitt C., Saavedra C., Bachi A., et al. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell 1 April (5) (1998) 649-659
8. Katahira J., Strasser K., Podtelejnikov A., Mann M., Jung J.U., and Hurt E. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J 18 May (9) (1999) 2593-2609
9. Aguilera A. Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. Curr Opin Cell Biol 17 June (3) (2005) 242-250
10. Reed R., and Cheng H. TREX, SR proteins and export of mRNA. Curr Opin Cell Biol 17 June (3) (2005) 269-273
11. Le Hir H., and Andersen G.R. Structural insights into the exon junction complex. Curr Opin Struct Biol 18 February (1) (2008) 112-119
12. Huang Y., Gattoni R., Stevenin J., and Steitz J.A. SR splicing factors serve as adapter proteins for TAP-dependent mRNA export. Mol Cell 11 March (3) (2003) 837-843
13. Zhou Z., Luo M.J., Straesser K., Katahira J., Hurt E., and Reed R. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407 September (6802) (2000) 401-405
14. Luo M.L., Zhou Z., Magni K., Christoforides C., Rappsilber J., Mann M., et al. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413 October (6856) (2001) 644-647
15. Cheng H., Dufu K., Lee C.S., Hsu J.L., Dias A., and Reed R. Human mRNA export machinery recruited to the 5′ end of mRNA. Cell 127 December (7) (2006) 1389-1400
16. Masuda S., Das R., Cheng H., Hurt E., Dorman N., and Reed R. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev 19 July (13) (2005) 1512-1517
17. Huang Y., and Steitz J.A. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. Mol Cell 7 April (4) (2001) 899-905
18. Cullen B.R. Nuclear RNA export. J Cell Sci 116 February (Pt 4) (2003) 587-597
19. Taniguchi I., and Ohno M. ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56. Mol Cell Biol 28 January (2) (2008) 601-608
20. Cullen B.R. Nuclear mRNA export: insights from virology. Trends Biochem Sci 28 August (8) (2003) 419-424
21. Chen I.H., Li L., Silva L., and Sandri-Goldin R.M. ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export. J Virol 79 April (7) (2005) 3949-3961
22. Koffa M.D., Clements J.B., Izaurralde E., Wadd S., Wilson S.A., Mattaj I.W., et al. Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J 20 October (20) (2001) 5769-5778
23. Lischka P., Toth Z., Thomas M., Mueller R., and Stamminger T. The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA. Mol Cell Biol 26 March (5) (2006) 1631-1643
24. Engelhardt O.G., Smith M., and Fodor E. Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II. J Virol 79 May (9) (2005) 5812-5818
25. Amorim M.J., Read E.K., Dalton R.M., Medcalf L., and Digard P. Nuclear export of influenza A virus mRNAs requires ongoing RNA polymerase II activity. Traffic (Copenhagen, Denmark) 8 January (1) (2007) 1-11
26. Vogel U., and Scholtissek C. Inhibition of the intracellular transport of influenza viral RNA by actinomycin D. Arch Virol 140 10 (1995) 1715-1723
27. Wang W., Cui Z.Q., Han H., Zhang Z.P., Wei H.P., Zhou Y.F., et al. Imaging and characterizing influenza A virus mRNA transport in living cells. Nucl Acids Res 36 September (15) (2008) 4913-4928
28. Hao L., Sakurai A., Watanabe T., Sorensen E., Nidom C.A., Newton M.A., et al. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 454 August (7206) (2008) 890-893
29. Wang W., and Krug R.M. The RNA-binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses. Virology 223 September (1) (1996) 41-50
30. Garaigorta U., Falcon A.M., and Ortin J. Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles. J Virol 79 December (24) (2005) 15246-15257
31. Ludwig S., Vogel U., and Scholtissek C. Amino acid replacements leading to temperature-sensitive defects of the NS1 protein of influenza A virus. Arch Virol 140 5 (1995) 945-950
32. Wolff T., Zielecki F., Abt M., Voss D., Semmler I., and Matthaei M. Sabotage of antiviral signaling and effectors by influenza viruses. Biol Chem 389 October (10) (2008) 1299-1305
33. Aragon T., de la Luna S., Novoa I., Carrasco L., Ortin J., and Nieto A. Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol 20 September (17) (2000) 6259-6268
34. Burgui I., Aragon T., Ortin J., and Nieto A. PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes. J Gen Virol 84 December (Pt 12) (2003) 3263-3274
35. Falcon A.M., Fortes P., Marion R.M., Beloso A., and Ortin J. Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucl Acids Res 27 January (11) (1999) 2241-2247
36. Greenspan D., Palese P., and Krystal M. Two nuclear location signals in the influenza virus NS1 nonstructural protein. J Virol 62 August (8) (1988) 3020-3026
37. Melen K., Kinnunen L., Fagerlund R., Ikonen N., Twu K.Y., Krug R.M., et al. Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes. J Virol 81 June (11) (2007) 5995-6006
38. Schneider J., Dauber B., Melen K., Julkunen I., and Wolff T. Analysis of influenza B Virus NS1 protein trafficking reveals a novel interaction with nuclear speckle domains. J Virol 83 January (2) (2009) 701-711
39. Fortes P., Beloso A., and Ortin J. Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J 13 February (3) (1994) 704-712
40. Qiu Y., and Krug R.M. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J Virol 68 April (4) (1994) 2425-2432
41. Nemeroff M.E., Barabino S.M., Li Y., Keller W., and Krug R.M. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′end formation of cellular pre-mRNAs. Mol Cell 1 June (7) (1998) 991-1000
42. Chen Z., Li Y., Krug R.M., and Influenza. A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′-end processing machinery. EMBO J 18 April (8) (1999) 2273-2283
43. Garaigorta U., and Ortin J. Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA. Nucl Acids Res 35 14 (2007) 4573-4582
44. Lamond A.I., and Spector D.L. Nuclear speckles: a model for nuclear organelles. Nat Rev 4 August (8) (2003) 605-612
45. Hall L.L., Smith K.P., Byron M., and Lawrence J.B. Molecular anatomy of a speckle. Anat Rec 288 July (7) (2006) 664-675
46. Phelan A., Carmo-Fonseca M., McLaughlan J., Lamond A.I., and Clements J.B. A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution. Proc Natl Acad Sci U S A 90 October (19) (1993) 9056-9060
47. Johnson L.A., and Sandri-Goldin R.M. Efficient nuclear export of herpes simplex virus transcripts requires both RNA binding by ICP27 and ICP27 interaction with TAP/NXF1. J Virol 83 February (3) (2009) 1184-1192
48. Satterly N., Tsai P.L., van Deursen J., Nussenzveig D.R., Wang Y., Faria P.A., et al. Influenza virus targets the mRNA export machinery and the nuclear pore complex. Proc Natl Acad Sci U S A 104 February (6) (2007) 1853-1858
49. Li Y., Yamakita Y., and Krug R.M. Regulation of a nuclear export signal by an adjacent inhibitory sequence: the effector domain of the influenza virus NS1 protein. Proc Natl Acad Sci U S A 95 April (9) (1998) 4864-4869