메뉴 건너뛰기




Volumn 31, Issue 9, 2009, Pages 981-992

Incomplete penetrance and variable expressivity: Is there a microRNA connection?

Author keywords

Epigenetics; Incomplete penetrance; MicroRNA; Modifier; Variable expressivity

Indexed keywords

HETEROCHROMATIN PROTEIN 1; MICRORNA; POLYCOMB GROUP PROTEIN;

EID: 70349970694     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.200900066     Document Type: Review
Times cited : (26)

References (77)
  • 1
    • 5444259253 scopus 로고    scopus 로고
    • Mechanisms of non-Mendelian inheritance in genetic disease
    • Heyningen, V. V. and Yeyati, P. L., Mechanisms of non-Mendelian inheritance in genetic disease. Hum Mol Genet 2004. 13: R225-R233.
    • (2004) Hum Mol Genet , vol.13
    • Heyningen, V.V.1    Yeyati, P.L.2
  • 2
    • 0142126381 scopus 로고    scopus 로고
    • Penetrance and expressivity in the molecular age
    • Zlotogora, J., Penetrance and expressivity in the molecular age. Genet Med 2003. 5: 347-352.
    • (2003) Genet Med , vol.5 , pp. 347-352
    • Zlotogora, J.1
  • 3
    • 70349896571 scopus 로고    scopus 로고
    • Stern, C., O. Vogt and the terms Penetrance and Expressivity. Am J Hum Genet 1960. 12: 141.
    • Stern, C., O. Vogt and the terms "Penetrance" and "Expressivity". Am J Hum Genet 1960. 12: 141.
  • 5
    • 0035296582 scopus 로고    scopus 로고
    • Genetics of type 2 diabetes: Insight from targeted mouse mutants
    • Accili, D., Kido, Y., Nakae, J., Lauro, D. and Park, B. C., Genetics of type 2 diabetes: insight from targeted mouse mutants. Curr Mol Med 2001. 1: 9-23.
    • (2001) Curr Mol Med , vol.1 , pp. 9-23
    • Accili, D.1    Kido, Y.2    Nakae, J.3    Lauro, D.4    Park, B.C.5
  • 6
    • 0030765634 scopus 로고    scopus 로고
    • Congenital absence of the vas deferens: Incomplete penetrance of cystic fibrosis gene mutations
    • Shin, D., Gilbert, F., Goldstein, M. and Schlegel, P. N., Congenital absence of the vas deferens: incomplete penetrance of cystic fibrosis gene mutations. J Urol 1997. 158: 1794-1798.
    • (1997) J Urol , vol.158 , pp. 1794-1798
    • Shin, D.1    Gilbert, F.2    Goldstein, M.3    Schlegel, P.N.4
  • 8
    • 33845536988 scopus 로고    scopus 로고
    • Co-existence of two functional mutations on the same allele of the human ferrochelatase gene in erythropoietic protoporphyria
    • Di, P. E., Brancaleoni, V., Moriondo, V., Besana, V. and Cappellini, M. D., Co-existence of two functional mutations on the same allele of the human ferrochelatase gene in erythropoietic protoporphyria. Clin Genet 2007. 71: 84-88.
    • (2007) Clin Genet , vol.71 , pp. 84-88
    • Di, P.E.1    Brancaleoni, V.2    Moriondo, V.3    Besana, V.4    Cappellini, M.D.5
  • 9
    • 34047255588 scopus 로고    scopus 로고
    • Mutations in the gene coding for the pre-mRNA splicing factor, PRPF31, in patients with autosomal dominant retinitis pigmentosa
    • Waseem, N. H., Vaclavik, V., Webster, A., Jenkins, S. A., Bird, A. C., et al. Mutations in the gene coding for the pre-mRNA splicing factor, PRPF31, in patients with autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 2007. 48: 1330-1334.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 1330-1334
    • Waseem, N.H.1    Vaclavik, V.2    Webster, A.3    Jenkins, S.A.4    Bird, A.C.5
  • 10
    • 0027379124 scopus 로고
    • Molecular etiology of low-penetrance retinoblastoma in two pedigrees
    • Dryja, T. P., Rapaport, J., McGee, T. L., Nork, T. M. and Schwartz, T. L., Molecular etiology of low-penetrance retinoblastoma in two pedigrees. Am J Hum Genet 1993. 52: 1122-1128.
    • (1993) Am J Hum Genet , vol.52 , pp. 1122-1128
    • Dryja, T.P.1    Rapaport, J.2    McGee, T.L.3    Nork, T.M.4    Schwartz, T.L.5
  • 11
    • 65349171533 scopus 로고    scopus 로고
    • Germline mutations in retinoma patients: Relevance to low-penetrance and low-expressivity molecular basis
    • Abouzeid, H., Schorderet, D. F., Balmer, A. and Munier, F. L., Germline mutations in retinoma patients: relevance to low-penetrance and low-expressivity molecular basis. Mol Vis 2009. 15: 771-777.
    • (2009) Mol Vis , vol.15 , pp. 771-777
    • Abouzeid, H.1    Schorderet, D.F.2    Balmer, A.3    Munier, F.L.4
  • 13
    • 0035499457 scopus 로고    scopus 로고
    • Reprogramming of genome function through epigenetic inheritance
    • Surani, M. A., Reprogramming of genome function through epigenetic inheritance. Nature 2001. 414: 122-128.
    • (2001) Nature , vol.414 , pp. 122-128
    • Surani, M.A.1
  • 14
    • 0036641071 scopus 로고    scopus 로고
    • X-chromosome inactivation: Closing in on proteins that bind Xist RNA
    • Brockdorff, N., X-chromosome inactivation: closing in on proteins that bind Xist RNA. Trends Genet 2002. 18: 352-358.
    • (2002) Trends Genet , vol.18 , pp. 352-358
    • Brockdorff, N.1
  • 15
    • 19344375746 scopus 로고    scopus 로고
    • A chromosomal memory triggered by Xist regulates histone methylation in X inactivation
    • Kohlmaier, A., Savarese, F., Lachner, M., Martens, J., Jenuwein, T. and Wutz, A., A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol 2004. 2: E171.
    • (2004) PLoS Biol , vol.2
    • Kohlmaier, A.1    Savarese, F.2    Lachner, M.3    Martens, J.4    Jenuwein, T.5    Wutz, A.6
  • 16
    • 0034713275 scopus 로고    scopus 로고
    • CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
    • Hark, A. T., Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 2000. 405: 486-489.
    • (2000) Nature , vol.405 , pp. 486-489
    • Hark, A.T.1    Schoenherr, C.J.2    Katz, D.J.3    Ingram, R.S.4    Levorse, J.M.5
  • 17
    • 0032963598 scopus 로고    scopus 로고
    • Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene
    • Khosla, S., Aitchison, A., Gregory, R., Allen, N. D. and Feil, R., Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene. Mol Cell Biol 1999. 19: 2556-2566
    • (1999) Mol Cell Biol , vol.19 , pp. 2556-2566
    • Khosla, S.1    Aitchison, A.2    Gregory, R.3    Allen, N.D.4    Feil, R.5
  • 18
    • 0027205671 scopus 로고
    • Allele-specific replication timing of imprinted gene regions
    • Kitsberg, D., Selig, S., Brandeis, M., Simon, I., Keshet, I., et al. Allele-specific replication timing of imprinted gene regions. Nature 1993. 364: 459-463.
    • (1993) Nature , vol.364 , pp. 459-463
    • Kitsberg, D.1    Selig, S.2    Brandeis, M.3    Simon, I.4    Keshet, I.5
  • 19
    • 0037444227 scopus 로고    scopus 로고
    • Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization
    • Gribnau, J., Hochedlinger, K., Hata, K., Li, E. and Jaenisch, R., Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. Genes Dev 2003. 17: 759-773.
    • (2003) Genes Dev , vol.17 , pp. 759-773
    • Gribnau, J.1    Hochedlinger, K.2    Hata, K.3    Li, E.4    Jaenisch, R.5
  • 20
    • 0037011058 scopus 로고    scopus 로고
    • Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes
    • Fournier, C., Goto, Y., Ballestar, E., Delaval, K., Hever, A. M., et al. Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J 2002. 21: 6560-6570.
    • (2002) EMBO J , vol.21 , pp. 6560-6570
    • Fournier, C.1    Goto, Y.2    Ballestar, E.3    Delaval, K.4    Hever, A.M.5
  • 22
    • 34548799689 scopus 로고    scopus 로고
    • MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation
    • Agarwal, N., Hardt, T., Brero, A., Nowak, D., Rothbauer, U., et al. MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. Nucleic Acids Res 2007. 35: 5402-5408.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5402-5408
    • Agarwal, N.1    Hardt, T.2    Brero, A.3    Nowak, D.4    Rothbauer, U.5
  • 24
    • 56949090665 scopus 로고    scopus 로고
    • Epigenetic regulation of cytomegalovirus major immediate-early promoter activity in transgenic mice
    • Mehta, A. K., Majumdar, S. S., Alam, P., Gulati, N. and Brahmachari, V., Epigenetic regulation of cytomegalovirus major immediate-early promoter activity in transgenic mice. Gene 2009. 428: 20-24.
    • (2009) Gene , vol.428 , pp. 20-24
    • Mehta, A.K.1    Majumdar, S.S.2    Alam, P.3    Gulati, N.4    Brahmachari, V.5
  • 25
    • 0026345716 scopus 로고
    • Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox
    • Fu, Y. H., Kuhl, D. P., Pizzuti, A., Pieretti, M., Sutcliffe, J. S., et al. Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell 1991. 67: 1047-1058.
    • (1991) Cell , vol.67 , pp. 1047-1058
    • Fu, Y.H.1    Kuhl, D.P.2    Pizzuti, A.3    Pieretti, M.4    Sutcliffe, J.S.5
  • 26
    • 0028264043 scopus 로고
    • High functioning fragile X males: Demonstration of an unmethylated fully expanded FMR-1 mutation associated with protein expression
    • Hagerman, R. J., Hull, C. E., Safanda, J. F., Carpenter, I., Staley, L. W., et al. High functioning fragile X males: demonstration of an unmethylated fully expanded FMR-1 mutation associated with protein expression. Am J Med Genet 1994. 51: 298-308.
    • (1994) Am J Med Genet , vol.51 , pp. 298-308
    • Hagerman, R.J.1    Hull, C.E.2    Safanda, J.F.3    Carpenter, I.4    Staley, L.W.5
  • 27
    • 33846319752 scopus 로고    scopus 로고
    • Allele dosage-dependent penetrance of RET proto-oncogene in an Israeli-Arab inbred family segregating Hirschsprung disease
    • Basel-Vanagaite, L., Pelet, A., Steiner, Z., Munnich, A., Rozenbach, Y., et al. Allele dosage-dependent penetrance of RET proto-oncogene in an Israeli-Arab inbred family segregating Hirschsprung disease. Eur J Hum Genet 2007. 15: 242-245.
    • (2007) Eur J Hum Genet , vol.15 , pp. 242-245
    • Basel-Vanagaite, L.1    Pelet, A.2    Steiner, Z.3    Munnich, A.4    Rozenbach, Y.5
  • 28
    • 0036337671 scopus 로고    scopus 로고
    • The penetrance of dominant erythropoietic protoporphyria is modulated by expression of wildtype FECH
    • Gouya, L., Puy, H., Robreau, A. M., Bourgeois, M., Lamoril, J., et al. The penetrance of dominant erythropoietic protoporphyria is modulated by expression of wildtype FECH. Nat Genet 2002. 30: 27-28.
    • (2002) Nat Genet , vol.30 , pp. 27-28
    • Gouya, L.1    Puy, H.2    Robreau, A.M.3    Bourgeois, M.4    Lamoril, J.5
  • 29
    • 0033663838 scopus 로고    scopus 로고
    • Molecular screening of the CFTR gene in men with anomalies of the vas deferens: Identification of three novel mutations
    • Jezequel, P., Dubourg, C., Le, L. D., Odent, S., le Gall, J. Y., et al. Molecular screening of the CFTR gene in men with anomalies of the vas deferens: identification of three novel mutations. Mol Hum Reprod 2000. 6: 1063-1067.
    • (2000) Mol Hum Reprod , vol.6 , pp. 1063-1067
    • Jezequel, P.1    Dubourg, C.2    Le, L.D.3    Odent, S.4    le Gall, J.Y.5
  • 30
    • 10744224159 scopus 로고    scopus 로고
    • A survey of genetic and epigenetic variation affecting human gene expression
    • Pastinen, T., Sladek, R., Gurd, S., Sammak, A., Ge, B., et al. A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics 2004. 16: 184-193.
    • (2004) Physiol Genomics , vol.16 , pp. 184-193
    • Pastinen, T.1    Sladek, R.2    Gurd, S.3    Sammak, A.4    Ge, B.5
  • 32
    • 0032756620 scopus 로고    scopus 로고
    • Clinical and molecular genetics of Alagille syndrome
    • Krantz, I. D., Piccoli, D. A. and Spinner, N. B., Clinical and molecular genetics of Alagille syndrome. Curr Opin Pediatr 1999. 11: 558-564.
    • (1999) Curr Opin Pediatr , vol.11 , pp. 558-564
    • Krantz, I.D.1    Piccoli, D.A.2    Spinner, N.B.3
  • 33
    • 0035684118 scopus 로고    scopus 로고
    • Phenotypic variability at the TGF-beta1 locus in Camurati-Engelmann disease
    • Campos-Xavier, B., Saraiva, J. M., Savarirayan, R., Verloes, A., Feingold, J., et al. Phenotypic variability at the TGF-beta1 locus in Camurati-Engelmann disease. Hum Genet 2001. 109: 653-658.
    • (2001) Hum Genet , vol.109 , pp. 653-658
    • Campos-Xavier, B.1    Saraiva, J.M.2    Savarirayan, R.3    Verloes, A.4    Feingold, J.5
  • 34
    • 0141755225 scopus 로고    scopus 로고
    • LIS1 missense mutations: Variable phenotypes result from unpredictable alterations in biochemical and cellular properties
    • Caspi, M., Coquelle, F. M., Koifman, C., Levy, T., Arai, H., et al. LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties. J Biol Chem 2003. 278: 38740-38748.
    • (2003) J Biol Chem , vol.278 , pp. 38740-38748
    • Caspi, M.1    Coquelle, F.M.2    Koifman, C.3    Levy, T.4    Arai, H.5
  • 35
    • 0141765726 scopus 로고    scopus 로고
    • Vithana, E. N., bu-Safieh, L., Pelosini, L., Winchester, E., Hornan, D., et al. Expression of PRPF31 mRNA in patients with autosomal dominant retinitis pigmentosa: a molecular clue for incomplete penetrance? Invest Ophthalmol Vis Sci 2003. 44: 4204-4209.
    • Vithana, E. N., bu-Safieh, L., Pelosini, L., Winchester, E., Hornan, D., et al. Expression of PRPF31 mRNA in patients with autosomal dominant retinitis pigmentosa: a molecular clue for incomplete penetrance? Invest Ophthalmol Vis Sci 2003. 44: 4204-4209.
  • 36
    • 34249664523 scopus 로고    scopus 로고
    • FGF23 concentrations vary with disease status in autosomal dominant hypophosphatemic rickets
    • Imel, E. A., Hui, S. L. and Econs, M. J., FGF23 concentrations vary with disease status in autosomal dominant hypophosphatemic rickets. J Bone Miner Res 2007. 22: 520-526.
    • (2007) J Bone Miner Res , vol.22 , pp. 520-526
    • Imel, E.A.1    Hui, S.L.2    Econs, M.J.3
  • 37
    • 34347324118 scopus 로고    scopus 로고
    • Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor
    • So, A. Y., Chaivorapol, C., Bolton, E. C., Li, H. and Yamamoto, K. R., Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet 2007. 3: e94.
    • (2007) PLoS Genet , vol.3
    • So, A.Y.1    Chaivorapol, C.2    Bolton, E.C.3    Li, H.4    Yamamoto, K.R.5
  • 38
    • 0028138909 scopus 로고
    • Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene
    • Ktistaki, E., Lacorte, J. M., Katrakili, N., Zannis, V. I. and Talianidis, I., Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene. Nucleic Acids Res 1994. 22: 4689-4696.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4689-4696
    • Ktistaki, E.1    Lacorte, J.M.2    Katrakili, N.3    Zannis, V.I.4    Talianidis, I.5
  • 39
    • 0036892346 scopus 로고    scopus 로고
    • Translational control of gene expression and disease
    • Calkhoven, C. F., Muller, C. and Leutz, A., Translational control of gene expression and disease. Trends Mol Med 2002. 8: 577-583.
    • (2002) Trends Mol Med , vol.8 , pp. 577-583
    • Calkhoven, C.F.1    Muller, C.2    Leutz, A.3
  • 40
    • 33847076246 scopus 로고    scopus 로고
    • Genetic and epigenetic regulators of pluripotency
    • Surani, M. A., Hayashi, K. and Hajkova, P., Genetic and epigenetic regulators of pluripotency. Cell 2007. 128: 747-762.
    • (2007) Cell , vol.128 , pp. 747-762
    • Surani, M.A.1    Hayashi, K.2    Hajkova, P.3
  • 41
    • 41149109085 scopus 로고    scopus 로고
    • Evidence for a novel x-linked modifier locus for leber hereditary optic neuropathy
    • Shankar, S. P., Fingert, J. H., Carelli, V., Valentino, M. L., King, T. M., et al. Evidence for a novel x-linked modifier locus for leber hereditary optic neuropathy. Ophthalmic Genet 2008. 29: 17-24.
    • (2008) Ophthalmic Genet , vol.29 , pp. 17-24
    • Shankar, S.P.1    Fingert, J.H.2    Carelli, V.3    Valentino, M.L.4    King, T.M.5
  • 42
    • 67649447243 scopus 로고    scopus 로고
    • Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and P53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers
    • Kontorovich, T., Cohen, Y., Nir, U. and Friedman, E., Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and P53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers. Breast Cancer Res Treat 2008. 19.
    • (2008) Breast Cancer Res Treat , pp. 19
    • Kontorovich, T.1    Cohen, Y.2    Nir, U.3    Friedman, E.4
  • 43
    • 0035853077 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers
    • Levy-Lahad, E., Lahad, A., Eisenberg, S., Dagan, E., Paperna, T., et al. A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers. Proc Natl Acad Sci USA 2001. 98: 3232-3236.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3232-3236
    • Levy-Lahad, E.1    Lahad, A.2    Eisenberg, S.3    Dagan, E.4    Paperna, T.5
  • 44
    • 23644451209 scopus 로고    scopus 로고
    • Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a
    • Bergren, S. K., Chen, S., Galecki, A. and Kearney, J. A., Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a. Mamm Genome 2005. 16: 683-690.
    • (2005) Mamm Genome , vol.16 , pp. 683-690
    • Bergren, S.K.1    Chen, S.2    Galecki, A.3    Kearney, J.A.4
  • 45
    • 20644436686 scopus 로고    scopus 로고
    • Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease
    • Owens, S. E., Broman, K. W., Wiltshire, T., Elmore, J. B., Bradley, K. M., et al. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet 2005. 14: 1549-1558.
    • (2005) Hum Mol Genet , vol.14 , pp. 1549-1558
    • Owens, S.E.1    Broman, K.W.2    Wiltshire, T.3    Elmore, J.B.4    Bradley, K.M.5
  • 46
    • 15944402920 scopus 로고    scopus 로고
    • Small regulatory RNAs in mammals
    • Mattick, J. S. and Makunin, I. V., Small regulatory RNAs in mammals. Hum Mol Genet 2005. 14: R121-R132.
    • (2005) Hum Mol Genet , vol.14
    • Mattick, J.S.1    Makunin, I.V.2
  • 47
    • 50949122690 scopus 로고    scopus 로고
    • Translational regulation by nonprotein-coding RNAs: Different targets, common themes
    • Xie, W., Ted, B. W. and Denman, R. B., Translational regulation by nonprotein-coding RNAs: different targets, common themes. Biochem Biophys Res Commun 2008. 373: 462-466.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 462-466
    • Xie, W.1    Ted, B.W.2    Denman, R.B.3
  • 48
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He, L. and Hannon, G. J., MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004. 5: 522-531.
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 49
    • 1942435249 scopus 로고    scopus 로고
    • Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs
    • Bartel, D. P. and Chen, C. Z., Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004. 5: 396-400.
    • (2004) Nat Rev Genet , vol.5 , pp. 396-400
    • Bartel, D.P.1    Chen, C.Z.2
  • 50
    • 33644659734 scopus 로고    scopus 로고
    • Mammalian microRNAs: A small world for fine-tuning gene expression
    • Sevignani, C., Calin, G. A., Siracusa, L. D. and Croce, C. M., Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome 2006. 17: 189-202.
    • (2006) Mamm Genome , vol.17 , pp. 189-202
    • Sevignani, C.1    Calin, G.A.2    Siracusa, L.D.3    Croce, C.M.4
  • 51
    • 33750296047 scopus 로고    scopus 로고
    • miR-7b, a microRNA upregulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation
    • Lee, H. J., Palkovits, M. and Young, W. S., III, miR-7b, a microRNA upregulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation. Proc Natl Acad Sci USA 2006. 103: 15669-15674.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15669-15674
    • Lee, H.J.1    Palkovits, M.2    Young III, W.S.3
  • 52
    • 34347266556 scopus 로고    scopus 로고
    • MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
    • Zhu, S., Si, M. L., Wu, H. and Mo, Y. Y., MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 2007. 282: 14328-14336.
    • (2007) J Biol Chem , vol.282 , pp. 14328-14336
    • Zhu, S.1    Si, M.L.2    Wu, H.3    Mo, Y.Y.4
  • 53
    • 34848927455 scopus 로고    scopus 로고
    • The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila
    • Karres, J. S., Hilgers, V., Carrera, I., Treisman, J. and Cohen, S. M., The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell 2007. 131: 136-145.
    • (2007) Cell , vol.131 , pp. 136-145
    • Karres, J.S.1    Hilgers, V.2    Carrera, I.3    Treisman, J.4    Cohen, S.M.5
  • 54
    • 35948975794 scopus 로고    scopus 로고
    • MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle
    • Visone, R., Russo, L., Pallante, P., De, M., Ferraro, A., et al. MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer 2007. 14: 791-798.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 791-798
    • Visone, R.1    Russo, L.2    Pallante, P.3    De, M.4    Ferraro, A.5
  • 55
    • 33847727035 scopus 로고    scopus 로고
    • How do microRNAs regulate gene expression?
    • Jackson, R. J. and Standart, N., How do microRNAs regulate gene expression? Sci STKE 2007. 2007: re1.
    • (2007) Sci STKE , vol.2007
    • Jackson, R.J.1    Standart, N.2
  • 56
    • 34249856066 scopus 로고    scopus 로고
    • Distance constraints between microRNA target sites dictate efficacy and cooperativity
    • Saetrom, P., Heale, B. S., Snove, O., Jr., Aagaard, L., Alluin, J., et al. Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Res 2007. 35: 2333-2342.
    • (2007) Nucleic Acids Res , vol.35 , pp. 2333-2342
    • Saetrom, P.1    Heale, B.S.2    Snove Jr., O.3    Aagaard, L.4    Alluin, J.5
  • 57
    • 20944450160 scopus 로고    scopus 로고
    • Combinatorial microRNA target predictions
    • Krek, A., Grun, D., Poy, M. N., Wolf, R., Rosenberg, L., et al. Combinatorial microRNA target predictions. Nat Genet 2005. 37: 495-500.
    • (2005) Nat Genet , vol.37 , pp. 495-500
    • Krek, A.1    Grun, D.2    Poy, M.N.3    Wolf, R.4    Rosenberg, L.5
  • 58
    • 41349096445 scopus 로고    scopus 로고
    • Gene regulation by transcription factors and microRNAs
    • Hobert, O., Gene regulation by transcription factors and microRNAs. Science 2008. 319: 1785-1786.
    • (2008) Science , vol.319 , pp. 1785-1786
    • Hobert, O.1
  • 59
    • 4344677175 scopus 로고    scopus 로고
    • Common logic of transcription factor and microRNA action
    • Hobert, O., Common logic of transcription factor and microRNA action. Trends Biochem Sci 2004. 29: 462-468.
    • (2004) Trends Biochem Sci , vol.29 , pp. 462-468
    • Hobert, O.1
  • 60
    • 84984765621 scopus 로고    scopus 로고
    • Canalization of development by micro-RNAs
    • Hornstein, E. and Shomron, N., Canalization of development by micro-RNAs. Nat Genet 2006. 38: S20-S24.
    • (2006) Nat Genet , vol.38
    • Hornstein, E.1    Shomron, N.2
  • 63
    • 4644237189 scopus 로고    scopus 로고
    • Fast and effective prediction of microRNA/target duplexes
    • Rehmsmeier, M., Steften, P., Hoschsmann, M. and Glegerich, R., Fast and effective prediction of microRNA/target duplexes. RNA 2004. 10: 1507-1517.
    • (2004) RNA , vol.10 , pp. 1507-1517
    • Rehmsmeier, M.1    Steften, P.2    Hoschsmann, M.3    Glegerich, R.4
  • 64
    • 35348847214 scopus 로고    scopus 로고
    • Prediction and validation of microRNA targets in animal genomes
    • Martin, G., Schouest, K., Kovvuru, P. and Spillane, C., Prediction and validation of microRNA targets in animal genomes. J Biosci 2007. 32: 1049-1052.
    • (2007) J Biosci , vol.32 , pp. 1049-1052
    • Martin, G.1    Schouest, K.2    Kovvuru, P.3    Spillane, C.4
  • 67
    • 0038692119 scopus 로고    scopus 로고
    • Human housekeeping genes are compact
    • Eisenberg, E. and Levanon, E. Y., Human housekeeping genes are compact. Trends Genet 2003. 19: 362-365.
    • (2003) Trends Genet , vol.19 , pp. 362-365
    • Eisenberg, E.1    Levanon, E.Y.2
  • 68
    • 6344281172 scopus 로고    scopus 로고
    • Identification of mammalian microRNA host genes and transcription units
    • Rodriguez, A., Griffiths-Jones, S., Ashurst, J. L. and Bradley, A., Identification of mammalian microRNA host genes and transcription units. Genome Res 2004. 14: 1902-1910.
    • (2004) Genome Res , vol.14 , pp. 1902-1910
    • Rodriguez, A.1    Griffiths-Jones, S.2    Ashurst, J.L.3    Bradley, A.4
  • 69
    • 0038005018 scopus 로고    scopus 로고
    • DAVID: Database for Annotation, Visualization, and Integrated Discovery
    • Dennis, G., Jr., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003. 4: 3.
    • (2003) Genome Biol , vol.4 , pp. 3
    • Dennis Jr., G.1    Sherman, B.T.2    Hosack, D.A.3    Yang, J.4    Gao, W.5
  • 70
    • 28944439309 scopus 로고    scopus 로고
    • Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution
    • Stark, A., Brennecke, J., Bushati, N., Russell, R. B. and Cohen, S. M., Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution. Cell 2005. 123: 1133-1146.
    • (2005) Cell , vol.123 , pp. 1133-1146
    • Stark, A.1    Brennecke, J.2    Bushati, N.3    Russell, R.B.4    Cohen, S.M.5
  • 71
    • 34347376692 scopus 로고    scopus 로고
    • Characterization of microRNA expression profiles in normal human tissues
    • Liang, Y., Ridzon, D., Wong, L. and Chen, C., Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 2007. 8: 166.
    • (2007) BMC Genomics , vol.8 , pp. 166
    • Liang, Y.1    Ridzon, D.2    Wong, L.3    Chen, C.4
  • 72
    • 34250877841 scopus 로고    scopus 로고
    • A mammalian microRNA expression atlas based on small RNA library sequencing
    • Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007. 129: 1401-1414.
    • (2007) Cell , vol.129 , pp. 1401-1414
    • Landgraf, P.1    Rusu, M.2    Sheridan, R.3    Sewer, A.4    Iovino, N.5
  • 73
    • 34249683280 scopus 로고    scopus 로고
    • Polymorphic miRNA-mediated gene regulation: Contribution to phenotypic variation and disease
    • Georges, M., Coppieters, W. and Charlier, C., Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease. Curr Opin Genet Dev 2007. 17: 166-176.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 166-176
    • Georges, M.1    Coppieters, W.2    Charlier, C.3
  • 74
    • 34548207751 scopus 로고    scopus 로고
    • The human angiotensin II type 1 receptor R1166 A/C polymorphism attenuates microrna-155 binding
    • Martin, M. M., Buckenberger, J. A., Jiang, J., Malana, G. E., Nuovo, G. J., et al. The human angiotensin II type 1 receptor R1166 A/C polymorphism attenuates microrna-155 binding. J Biol Chem 2007. 282: 24262-24269.
    • (2007) J Biol Chem , vol.282 , pp. 24262-24269
    • Martin, M.M.1    Buckenberger, J.A.2    Jiang, J.3    Malana, G.E.4    Nuovo, G.J.5
  • 75
    • 18844380174 scopus 로고    scopus 로고
    • Polymorphisms in human pre-miRNAs
    • Iwai, N. and Naraba, H., Polymorphisms in human pre-miRNAs. Biochem Biophys Res Commun 2005. 331: 1439-1444.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 1439-1444
    • Iwai, N.1    Naraba, H.2
  • 76
    • 65649124187 scopus 로고    scopus 로고
    • dbSMR: A novel resource of genome-wide SNPs affecting microRNA mediated regulation
    • Hariharan, M., Scaria, V. and Brahmachari, S. K., dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation. BMC Bioinformatics 2009. 10: 108.
    • (2009) BMC Bioinformatics , vol.10 , pp. 108
    • Hariharan, M.1    Scaria, V.2    Brahmachari, S.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.