A spontaneous lactate dehydrogenase deficient mutant of Streptococcus rattus for use as a probiotic in the prevention of dental caries

Journal of Applied Microbiology

Volumn 107, Issue 5, 2009, Pages 1551-1558

  Hillman, J D ^a   McDonell, E ^a   Cramm, T ^a   Hillman, C H ^b   Zahradnik, R T ^a  

^a Oragenics Inc   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Dental caries; Lactate dehydrogenase; Probiotic; Streptococcus rattus

Indexed keywords

DENTAL CARIES; L-LACTATE; LACTATE DEHYDROGENASE; PROBIOTICS; RAT MODEL; S. MUTANS; SELECTIVE MEDIUM; SINGLE BASIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS RATTI;

ANIMALS;

LACTATE DEHYDROGENASE; PROBIOTIC AGENT;

BACTERIUM; BIOTECHNOLOGY; DENTAL HEALTH; DISEASE CONTROL; ENZYME ACTIVITY; HEMATOLOGY; MUTATION; PROBIOTICS; PUBLIC HEALTH;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIUM MUTANT; CARIES PREVENTION; CONTROLLED STUDY; DENTAL CARIES; ENZYME DEFICIENCY; FEMALE; GENE MUTATION; MALE; NONHUMAN; RAT; STREPTOCOCCUS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS RATTUS; STRUCTURAL GENE;

ANIMALIA; RATTUS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS RATTI;

EID: 70349960036     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2009.04333.x     Document Type: Article

References (27)

1. Bochner, B.R. Savageau, M.A. (1977) Generalized indicator plate for genetic, metabolic, and taxonomic studies with microorganisms. Appl Environ Microbiol 33, 434 444.
2. Bratthall, D. Kohler, B. (1976) Streptococcus mutans serotypes: some aspects of their identification, distribution, antigenic shifts, and relationship to caries. J Dent Res 55 Spec No., C15 C21.
3. ten Cate, J.M. van Loveren, C. (1992) Saliva, caries and diagnostics. Ned Tijdschr Tandheelkd 99, 85 88.
4. Caufield, P.W., Li, Y. Dasanayake, A. (2005) Dental caries: an infectious and transmissible disease. Compend Contin Educ Dent 26 (Suppl. 1 10 16.
5. Coykendall, A.L. (1989) Classification and identification of the viridans streptococci. Clin Microbiol Rev 2, 315 328.
6. Featherstone, J.D. (2000) The science and practice of caries prevention. J Am Dent Assoc 131, 887 899.
7. Gibbons, R.J. Nygaard, M. (1968) Synthesis of insoluble dextran and its significance in the formation of gelatinous deposits by plaque-forming streptococci. Arch Oral Biol 13, 1249 1262.
8. Gutierrez, J.A., Crowley, P.J., Brown, D.P., Hillman, J.D., Youngman, P. Bleiweis, A.S. (1996) Insertional mutagenesis and recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminary characterization of mutants displaying acid sensitivity and nutritional requirements. J Bacteriol 178, 4166 4175.
9. Hardie, J.M. (1992) Oral microbiology: current concepts in the microbiology of dental caries and periodontal disease. Br Dent J 172, 271 278.
10. Hillman, J.D. (1978) Lactate dehydrogenase mutants of Streptococcus mutans: isolation and preliminary characterization. Infect Immun 21, 206 212.
11. Hillman, J.D. (2002) Genetically modified Streptococcus mutans for prevention of dental caries. Antoine Leewenhock 82, 361 366.
12. Hillman, J.D., Andrews, S.W. Dzuback, A.L. (1987) Acetoin production by wild-type strains and a lactate dehydrogenase-deficient mutant of Streptococcus mutans. Infect Immun 55, 1399 1402.
13. Hillman, J.D., Chen, A., Duncan, M. Lee, S.W. (1994) Evidence that L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans. Infect Immun 62, 60 64. (Pubitemid 24011940)
14. Hillman, J.D., Chen, A. Snoep, J.L. (1996) Genetic and physiological analysis of the lethal effect of L-(+)-lactate dehydrogenase deficiency in Streptococcus mutans: complementation by alcohol dehydrogenase from Zymomonas mobilis. Infect Immun 64, 4319 4323.
15. Hillman, J.D., Brooks, T.A., Michalek, S.M., Harman, C.C., Snoep, J.L. van Der Weijden, C.C. (2000) Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental caries. Infect Immun 68, 543 549.
16. Johnson, C.P., Gross, S.M. Hillman, J.D. (1980) Cariogenic potential in vitro in man and in vivo in the rat of lactate dehydrogenase mutants of Streptococcus mutans. Arch Oral Biol 25, 707 713.
17. Kuramitsu, H.K. (2003) Molecular genetic analysis of the virulence of oral bacterial pathogens: an historical perspective. Crit Rev Oral Biol Med 14, 331 344.
18. Lederberg, J. (1948) Detection of fermentative variants with tetrazolium. J Bacteriol 56, 695.
19. Lee, S.F., Progulske-Fox, A., Erdos, G.W., Piacentini, D.A., Ayakawa, C.Y., Crowley, P.J. Bleiweis, A.S. (1989) Construction and characterization of isogenic mutants of Streptococcus mutans deficient in major surface protein antigen P1 (I/II). Infect Immun 57, 3306 3313.
20. Marsh, P.D. (1991) Sugar, fluoride, pH and microbial homeostasis in dental plaque. Proc Finn Dent Soc 87, 515 525.
21. Marsh, P.D. (1994) Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res 8, 263 271.
22. Marsh, P.D. (2005) Dental plaque: biological significance of a biofilm and community life-style. J Clin Periodontol 32, 7 15.
23. Ozaki, K., Matsuo, T., Nakae, H., Noiri, Y., Yoshiyama, M. Ebisu, S. (1994) A quantitative comparison of selected bacteria in human carious dentine by microscopic counts. Caries Res 28, 137 145.
24. Pineiro, M. Stanton, C. (2007) Probiotic bacteria: legislative framework - requirements to evidence basis. J Nutr 137 (Suppl. 2 850S 853S.
25. Ruiz Miravet, A., Montiel Company, J.M. Almerich Silla, J.M. (2007) Evaluation of caries risk in a young adult population. Med Oral Patol Oral Cir Bucal 12, E412 E418.
26. Tanzer, J.M., Livingston, J. Thompson, A.M. (2001) The microbiology of primary dental caries in humans. J Dent Educ 65, 1028 1037.
27. Walker, R. Buckley, M. (ed 2006) Probiotic microbes: the scientific basis. A Report of the American Academy of Microbiology. Washington, DC : American Society for Microbiology.