Platelet counts and haemorrhagic diathesis in patients with myelodysplastic syndromes

European Journal of Haematology

Volumn 83, Issue 5, 2009, Pages 477-482

  Neukirchen, Judith ^a   Blum, Sabine ^b   Kuendgen, Andrea ^a   Strupp, Corinna ^a   Aivado, Manuel ^a,c   Haas, Rainer ^a   Aul, Carlo ^d   Gattermann, Norbert ^a   Germing, Ulrich ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c GLAXOSMITHKLINE   (United States)

^d ST JOHANNES HOSPITAL   (Germany)

Author keywords

Bleeding; Dysmegakaryopoiesis; Haemorrhagic complications; Myelodysplastic syndromes; Platelets; Thrombocytopenia

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING; BLEEDING TENDENCY; BLOOD SMEAR; BONE MARROW BIOPSY; CANCER RISK; CAUSE OF DEATH; CORRELATION ANALYSIS; DISEASE COURSE; DYSMEGAKARYOPOIESIS; FEMALE; HUMAN; KARYOTYPING; MAJOR CLINICAL STUDY; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; PREDICTOR VARIABLE; PRIORITY JOURNAL; SURVIVAL; THROMBOCYTE COUNT; THROMBOCYTE STRUCTURE; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

DISEASE-FREE SURVIVAL; FEMALE; HEMORRHAGIC DISORDERS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MYELODYSPLASTIC SYNDROMES; PLATELET COUNT; PLATELET TRANSFUSION; PREDICTIVE VALUE OF TESTS; REGISTRIES; RETROSPECTIVE STUDIES; SURVIVAL RATE; THROMBOCYTOPENIA;

EID: 70349952484     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2009.01299.x     Document Type: Article

References (14)

1. Sanz GF, Sanz MA, Greenberg PL. Prognostic factors and scoring systems in myelodysplastic syndromes. Haematologica 1998 83 : 358 368.
2. Aul C, Giagounidis A, Germing U, Ganser A. Evaluating the prognosis of patients with myelodysplastic syndromes. Ann Hematol 2002 81 : 485 497. (Pubitemid 36075500)
3. Kantarjian H, Giles F, List A, Lyons R, Sekeres MA, Pierce S, Deuson R, Leveque J. The incidence and impact of thrombocytopenia in myelodysplastic syndromes. Cancer 2007 109 : 1705 1714. (Pubitemid 46668530)
4. Steensma DP, Bennett JM. The myelodysplastic syndromes: diagnosis and treatment. Mayo Clin Proc 2006 81 : 104 130.
5. Hofmann WK, Kalina U, Koschmieder S, Seipelt G, Hoelzer D, Ottmann OG. Defective megakaryocytic development in myelodysplastic syndromes. Leuk Lymphoma 2000 38 : 13 9.
6. Van Lom K, Houtsmuller AB, van Putten WL, Slater RM, Löwenberg B. Cytogenetic clonality analysis of megakaryocytes in myelodysplastic syndrome by dual-color fluorescence in situ hybridization and confocal laser scanning microscopy. Genes Chromosomes Cancer 1999 25 : 332 338.
7. Germing U, Strupp C, Kuendgen A, Bowen D, Aul C, Haas R, Gattermann N. No increase in age-specific incidence of myelodysplastic syndromes. Haematologica 2004 89 : 905 910.
8. Germing U, Strupp C, Kuendgen A, Isa S, Knipp S, Hildebrandt B, Giagounidis A, Aul C, Gattermann N, Haas R. Prospective validation of the WHO proposals for the classification of myelodysplastic syndromes. Haematologica 2006 91 : 1596 1604.
9. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton GA, Gralnick HR, Sultan C. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982 51 : 189 199.
10. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 1999 17 : 3835 3849.
11. Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997 89 : 2079 2088.
12. Kantarjian H, O'Brien S, Ravandi F, et al. Proposal for a new risk model in myelodysplastic syndromes that accounts for events not considered in the original international prognostic scoring system. Cancer 2008 113 : 1351 1361.
13. Bowles KM, Warner BA, Baglin TP. Platelet mass has prognostic value in patients with myelodysplastic syndromes. Br J Haematol 2006 135 : 198 200.
14. Germing U, Platzbecker U, Giagounidis A, Aul C. Platelet morphology, platelet mass, platelet count and prognosis in patients with myelodysplastic syndromes. Br J Haematol 2007 138 : 399 400.