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A. Gradillas, J. Pérez-Castells, Angew. Chem. 2006, 118, 6232-6247; Angew. Chem. Int. Ed. 2006, 45, 6086-6101.
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3
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70349971306
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Other well-known macrocyclization methods are encountered, but less frequently, for example, Horner-Wadsworth-Emmons, Nozaki-Hiyama-Kishi, and intramolecular cross-coupling
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Other well-known macrocyclization methods are encountered, but less frequently, for example, Horner-Wadsworth-Emmons, Nozaki-Hiyama-Kishi, and intramolecular cross-coupling.
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5
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0035984562
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For a review on the chemistry and biology of the bryostatins, see
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For a review on the chemistry and biology of the bryostatins, see: K. J. Hale, M. G. Hummersone, S. Manaviazar, M. Frigerio, Nat. Prod. Rep. 2002, 19, 413-453.
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7
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70349964242
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For current information, see
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For current information, see http://clinicaltrials.gov.
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9
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0025053566
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For a total synthesis of bryostatin 7, see
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(a) For a total synthesis of bryostatin 7, see: M. Kageyama, T. Tamura, M. H. Nantz, J. C. Roberts, P. Somfai, D. C. Whritenour, S. Masamune, J. Am. Chem. Soc. 1990, 112, 7407-7408;
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10
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0033603858
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for bryostatin 2, see
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b) for bryostatin 2, see: D. A. Evans, P. H. Carter, E. M. Carreira, A. B. Charette, J. A. Prunet, M. Lautens, J. Am. Chem. Soc. 1999, 121, 7540-7552;
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Prunet, J.A.5
Lautens, M.6
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11
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70349964234
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for bryostatin 3, see: K. Ohmori, Y. Ogawa, T. Obitsu, Y. Ishikawa, S. Nishiyama, S. Yamamura, Angew. Chem. 2000, 112, 2376-2379; Angew. Chem. Int. Ed. 2000, 39, 2290-2294.
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c) for bryostatin 3, see: K. Ohmori, Y. Ogawa, T. Obitsu, Y. Ishikawa, S. Nishiyama, S. Yamamura, Angew. Chem. 2000, 112, 2376-2379; Angew. Chem. Int. Ed. 2000, 39, 2290-2294.
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12
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44349096284
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For a fascinating Prins-driven macrocyclization strategy toward bryostatin analogues, see
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For a fascinating Prins-driven macrocyclization strategy toward bryostatin analogues, see: P. A. Wender, B. A. DeChristopher, A. J. Schrier, J. Am. Chem. Soc. 2008, 130, 6658-6659.
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B. M. Trost, H. Tang, G. A. Wuitschik, Org. Lett. 2005, 7, 4761 - 4764.
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Org. Lett
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0037146084
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P. A. Wender, J. L. Baryza, C. E. Bennett, F. C. Bi, S. E. Brenner, M. O. Clarke, J. C. Horan, C. Kan, E. Lacôte, B. Lippa, P. G. Nell, T. M. Turner, J. Am. Chem. Soc. 2002, 124, 13648-13649.
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Nell, P.G.11
Turner, T.M.12
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19
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70349950388
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Trost et al. previously described a 16-step synthesis of 8 from (R)-pantolactone; see: reference [11].
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Trost et al. previously described a 16-step synthesis of 8 from (R)-pantolactone; see: reference [11].
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20
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27144528601
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B. M. Trost, H. Yang, G. A. Wuitschik, Org. Lett. 2005, 7, 4761 - 4764.
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