De novo design of a bab motif

Angewandte Chemie - International Edition

Volumn 48, Issue 18, 2009, Pages 3301-3303

  Liang, Huanhuan ^b   Chen, Hao ^d   Fan, Keqiang ^b   Wei, Ping ^b   Guo, Xianrong ^c   Jin, Changwen ^c   Zeng, Chen ^d   Tang, Chao ^e   Lai, Luhua ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c Beijing Nuclear Magnetic Resonance Center   (China)

^d GEORGE WASHINGTON UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CODED AMINO ACIDS; DE NOVO DESIGN; HIGH THERMAL STABILITY; MONOMERIC PROTEINS; TRYPTOPHAN-TRYPTOPHAN INTERACTIONS;

AMINES; ORGANIC ACIDS; THERMODYNAMIC STABILITY;

AMINO ACIDS;

PROTEIN;

AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; MOLECULAR GENETICS; MUTATION; PROTEIN FOLDING; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN FOLDING; PROTEINS;

EID: 70349924965     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200805476     Document Type: Article

References (27)

1. (a) J. Kaplan, W. F. DeGrado, Proc. Natl. Acad. Sci. USA 2004, 101,11566;
2. b) X. I. Ambroggio, B. Kuhlman, Curr. Opin. Struct. Biol. 2006, 16, 525;
3. c) S. M. Butterfield, W. J. Cooper, M. L. Waters,J. Am. Chem. Soc. 2005, 127, 24;
4. d) O. Iranzo, C. Cabello, V. L. Pecoraro, Angew. Chem. 2007, 119, 6808; Angew. Chem. Int. Ed. 2007, 46, 6688.
5. (a) J. Venkatraman, S. C. Shankaramma, P. Balaram, Chem. Rev. 2001, 101, 3131;
6. b) L. Baltzer, H. Nilsson, J. Nilsson, Chem. Rev. 2001, 101, 3153;
7. c) R. M. Hughes, M. L. Waters, Curr. Opin. Struct. Biol. 2006, 16, 514;
8. d) R. B. Hill, D. P. Raleigh, A. Lombardi, W. F. DeGrado, Acc. Chem. Res. 2000, 33, 745.
9. (a) B. I. Dahiyat, A. Heitz, L. Chiche, P. Derreumaux, Science 1997, 278, 82;
10. b) B. Kuhlman, Science 2003, 302, 1364.
11. M. Coinçon, A. Heitz, L. Chiche, P. Derreumaux, Proteins Struct. Funct. Genet. 2005, 60, 740.
12. See the Supporting Information.
13. (a)IUPAC, Biochemistry 1970, 9, 3471;
14. b) P. Y. Chou, G. D. Fasman, Annu. Rev. Biochem. 1978, 47, 251;
15. c) K. T. O'Neil, W. F. DeGrado, Science 1990, 250, 646;
16. d) C. Toniolo, Macro-molecules 1978, 11, 437;
17. e) H. Xiong, B. L. Buckwalter, H. M. Shieh, M. H. Hecht, Proc. Natl. Acad. Sci. USA 1995, 92, 6349;
18. f) S. Marqusee, R. L. Baldwin, Proc. Natl. Acad. Sci. USA 1987, 84, 8898;
19. g) R. Aurora, G. D. Rose, Protein Sci. 1998, 7, 21.
20. (a) A. G. Cochran, N. J. Skelton, M. A. Starovasnik, Proc. Natl. Acad. Sci. USA 2001, 98, 5578;
21. b) M. Dhanasekaran, O. Prakash, Y. X. Gong, P. W. Baures, Org Biomol. Chem. 2004, 2, 2071;
22. c) W. W. Streicher, G. I. Makhatadze, J. Am. Chem. Soc. 2006, 128, 30.
23. (a) J. S. Richardson, D. C. Richardson, Proc. Natl. Acad. Sci. USA 2002, 99, 2754;
24. b) W. Wang, M. H. Hecht, Proc. Natl Acad. Sci. USA 2002, 99, 2760.
25. (a) Figure 4a was created with MOLMOL: R. Koradi, M. Billeter, K. Wuthrich, J. Mol. Graph. 1996, 14, 51; the structures in Figure 4b,C. were created with PyMOL:
26. b) http://pymol.sour-ceforge.net/.
27. Y. Qi et al., unpublished results.