Efficacy of low dose dexamethasone in severe thrombocytopenia caused by dengue fever: A placebo controlled study

Postgraduate Medical Journal

Volumn 85, Issue 1008, 2009, Pages 525-529

  Kularatne, S A M ^a   Walathara, C ^a   Mahindawansa, S I ^a   Wijesinghe, S ^a   Pathirage, M M K ^a   Kumarasiri, P V R ^a   Dissanayake, A M S D M ^a  

^a UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; HEMOGLOBIN; PLACEBO;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY TEMPERATURE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENGUE; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HEADACHE; HEMATOCRIT; HUMAN; LEUKOCYTE COUNT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NAUSEA; PULSE RATE; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SRI LANKA; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; CHILD; DENGUE; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; SEVERITY OF ILLNESS INDEX; THROMBOCYTOPENIA; TREATMENT OUTCOME; YOUNG ADULT;

EID: 70349920772     PISSN: 00325473     EISSN: 14690756     Source Type: Journal    
DOI: 10.1136/pgmj.2008.078444     Document Type: Article

References (18)

1. Messer WB, Vitarana UT, Sivananthan K, et al. Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever. Am J Trop Med Hyg 2002;66:765-773 (Pubitemid 35001053)
2. Kularatne SAM, Seneviratne SL, Malavige S, et al. Synopsis of findings from recent studies on dengue in Sri Lanka. Den Bull 2006;30:80-86
3. Panpanich R, Sornchai P, Kanjanaratanakorn K. Corticosteroids for treating dengue shock syndrome. Cochrane Database of Systematic Reviews 2006; (issue 3): CD003488.
4. Kularatne SAM. Survey on the management of dengue infection in Sri Lanka: opinion of physicians and pediatricians. Southeast Asian J Trop Med Public Health 2005;36:1198-1200
5. Douglas B, Cines MD, Victor S, et al. Immune thrombocytopenic purpura. N Engl J Med 2002;346:995-1008.
6. Kularatne SAM, Gawarammana IB, Kumarasiri PRV. Epidemiology, clinical features, laboratory investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka. Southeast Asian J Trop Med Public Health 2005;36:282-288
7. Pocock SJ. Clinical trials, a practical approach. New York: John Wiley and Sons, 1995:121-126
8. Schults KS, Grimes DA. Generation of allocation sequences in randomized trials: chance, not choice. Lancet 2002;359:515-519
9. Futrakul P, Poshyachinda M, Mitrakul C, et al. Hemodynamic response to high-dose methyl prednisolone and mannitol in severe dengue-shock patients unresponsive to fluid replacement. Southeast Asian J Trop Med Public Health 1987;18:373-379 (Pubitemid 18031388)
10. Tassniyom S, Vasanawathana S, Chirawatkul A, et al. Failure of high-dose methylprednisolone in established dengue shock syndrome: a placebo-controlled, double-blind study. Pediatrics 1993;92:111-115 (Pubitemid 23188877)
11. Sumarmo, Talogo W, Asrin A, et al. Failure of hydrocortisone to affect outcome in dengue shock syndrome. Pediatrics 1982;69:459. (Pubitemid 12209667)
12. Min M, U T, Aye M, et al. Hydrocortisone in the management of dengue shock syndrome. Southeast Asian J Trop Med Public Health 1975;6:573-579
13. Finsterer J, Kongchan K. Severe, persisting, steroid-responsive Dengue myositis. J Clinical Virology 2006;35:426-428 (Pubitemid 43324840)
14. Myo-Khin, Soe-Thein, Thein-Thein-Myint, et al. Serum cortisol levels in children with dengue haemorrhagic fever. J Trop Pediats1995;41:295-297
15. Rajapakse S. Corticosteroids in the treatment of dengue illness. Trans R Soc Trop Med Hyg 2009;103:122-126
16. Blanchette V, Imbach P, Andrew M, et al. Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet 1994;344:703-707 (Pubitemid 24281420)
17. De Castro RA, de Castro JA, Bares MY, et al. Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-(Rh(0)-D) immune globin. Am J Trop Med Hyg 2007;76:737-742
18. Dimaano EM, Saito M, Honda S, et al. Lack of efficacy of high- dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection. Am J Trop Med Hyg 2007;77:1135-1138 (Pubitemid 351837807)