Tetracycline in liquid manure selects for co-occurrence of the resistance genes tet(M) and tet(L) in Enterococcus faecalis

Veterinary Microbiology

Volumn 139, Issue 3-4, 2009, Pages 386-392

  Schwaiger, Karin ^a   Harms, Katrin ^a   Hölzel, Christina ^a   Meyer, Karsten ^a   Karl, Marianne ^a   Bauer, Johann ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antimicrobial resistance; Liquid manure; Minimum inhibitory concentration; Selection; tet(L); tet(M); tet(O); tet(S); Tetracycline

Indexed keywords

BACTERIAL PROTEIN; CHLORTETRACYCLINE; DOXYCYCLINE; OXYTETRACYCLINE; TETL PROTEIN; TETM PROTEIN; TETO PROTEIN; TETRACYCLINE; TETS PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATION; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; FECES ANALYSIS; FECES MICROFLORA; GERMANY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PIG FARMING; POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, MICROBIAL; ENTEROCOCCUS FAECALIS; GERMANY; MANURE; MOLECULAR SEQUENCE DATA; RNA, RIBOSOMAL, 16S; SOIL MICROBIOLOGY; SWINE; TETRACYCLINE; TETRACYCLINE RESISTANCE;

ENTEROCOCCUS FAECALIS; SUIDAE;

EID: 70349907710     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2009.06.005     Document Type: Article

References (28)

1. Aminov R.I., Chee-Sandford J., Garrigues C., Teferedegne N.B., Krapac I.J., White B.A., and Macki R.I. Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram negative bacteria. Appl. Environ. Microbiol. 68 (2002) 1786-1793
2. Aarestrup F.M., Agerso Y., Gerner-Smidt P., Madsen M., and Jensen L.B. Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark. Diagn. Microbiol. Infect. Dis. 37 (2000) 127-137
3. Bejuk D., Begovac J., Gamberger D., and Kucisec-Tepes N. Evaluation of phenotypic characteristics for differentiation of enterococcal species using an example based algorithm. Diagn. Microbiol. Infect. Dis. 38 (2000) 201-205
4. Bousquet E., Morvan H., Aitken I., and Morgan J.H. Comparative in vitro activity of doxycycline and oxytetracycline against porcine respiratory pathogens. Vet. Rec. 141 (1997) 37-40
5. Blake D.P., Humphry R.W., Scott K.P., Hillman K., Fenlon D.R., and Low J.C. Influence of tetracycline exposure on tetracycline resistance and the carriage of tetracycline resistance genes within commensal Escherichia coli populations. J. Appl. Microbiol. 94 (2003) 1087-1097
6. Chopra I., and Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol. Rev. 65 (2001) 232-260
7. DIN 58940-81. Medical Microbiology-Susceptibility Testing of Microbial Pathogens to Antimicrobial Agents. Part 81. Microdilution-Special Requirements for Testing of Non-fastidious Bacteria (2002), Beuth-Verlag, Berlin
8. DIN 58940-4 Supplement 1, 2004. Medical Microbiology-Susceptibility Testing of Pathogens to Antimicrobial Agents. Part 4. Evaluation Classes of the Minimum Inhibitory Concentration-MIC-breakpoints of antibacterial agents. Beuth-Verlag, Berlin.
9. FEDESA, 1998. Verbrauch von Antibiotika. Deutsches Tierärzteblatt 11, 1093.
10. EG 1831/2003: Verordnung (EG) Nr. 1831/2003 des Europäischen Parlaments und des Rates vom 22. September 2003 über Zusatzstoffe zur Verwendung in der Tierernährung. Amtsblatt der Europäischen Union, L268/29.
11. GERMAP, 2008. Antibiotika-Resistenz und -Verbrauch. Bericht über den Antibiotikaverbrauch und die Verbreitung von Antibiotikaresistenzen in der Human- und Veterinärmedizin in Deutschland. Bundesamt für Verbraucherschutz und Lebensmittelsicherheit; Paul-Ehrlich-Gesellschaft für Chemotherapie e.V.; Infektiologie Freiburg, 1-149.
12. Harms, K., 2006. Untersuchungen zum Nachweis und Vorkommen von Antibiotika und deren Metaboliten in Schweinegülle. Dissertation; Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Technische Universität München.
13. Hölzel C.S., and Bauer J. Salmonella spp. in Bavarian liquid pig manure: occurrence and relevance for the distribution of antibiotic resistance. Zoonoses Public Health 55 (2008) 133-138
14. Huys G., D'Haene K., Collard J.M., and Swings J. Prevalence and molecular characterization of tetracycline resistance in Enterococcus isolates from food. Appl. Environ. Microbiol. 70 (2004) 1555-1562
15. Lanz R., Kuhnert P., and Boerlin P. Antimicrobial resistance and resistance gene determinants in clinical Escherichia coli from different animal species in Switzerland. Vet. Microbiol. 2. 91 (2003) 73-84
16. Lenski R.E. The cost of antibiotic resistance-from the perspective of a bacterium. Ciba Found. Symp. 207 (1997) 131-140 (discussion 141-51)
17. Macovei L., and Zurek L. Ecology of antibiotic resistance genes: characterization of enterococci from houseflies collected in food settings. Appl. Environ. Microbiol. 72 (2006) 4688-4694
18. Maynard C., Bekal S., Sanschagrin F., Levesque R.C., Brousseau R., Masson L., Larivière S., and Harel J. Heterogeneity among virulence and antimicrobial resistance gene profiles of extraintestinal Escherichia coli isolates of animal and human origin. J. Clin. Microbiol. 42 (2004) 5444-5452
19. Ng L.K., Martin I., Alfa M., and Mulvey M. Multiplex PCR for the detection of tetracycline resistant genes. Mol. Cell. Probes 15 (2001) 209-215
20. OIE, 2001: Office International des Épizooties. OIE guidelines. 2nd OIE International Conference on Antimicrobial Resistance. Use of antimicrobials and protection of public health. http://www.anmv.afssa.fr/oiecc/conference/guidelines.htm.
21. Phillips I., Casewell M., Cox T., De Groot B., Friis C., Jones R., Nightingale C., Preston R., and Waddell J. Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. J. Antimicrob. Chemother. 53 (2004) 28-52
22. Rosin H. Antibiotika und Chemotherapeutika-Antiinfektiöse Therapie. In: Forth W., Henschler D., Rummel W., and Starke K. (Eds). In: Allgemeine und spezielle Pharmakologie und Toxikologie. 6th ed. (1992), B.I. Wissenschaftsverlag, Mannheim/Leipzig/Wien/Zürich
23. Schwaiger K., Schmied E.M., and Bauer J. Comparative analysis of antibiotic resistance characteristics of Gram-negative bacteria isolated from laying hens and eggs in conventional and organic keeping systems in Bavaria, Germany. Zoonoses Public Health 55 (2008) 331-341
24. Sczesny S., Nau H., and Hamscher G. Residue analysis of tetracyclines and their metabolites in eggs and in the environment by HPLC coupled with a microbiological assay and tandem mass spectrometry. J. Agric. Food Chem. 51 (2003) 697-703
25. Sukul P., Lamshöft M., Kusari S., Zühlke S., and Spiteller M. Metabolism and excretion kinetics of 14C-labeled and non-labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites. Environ. Res. 109 (2009) 225-231
26. Trzcinski K., Cooper B.S., Hryniewicz W., and Dowson C.G. Expression of resistance to tetracyclines in strains of methicillin-resistant Staphylococcus aureus. J. Antimicrob. Chemother. 45 (2000) 763-770
27. Villedieu A., Diaz-Torres M.L., Hunt N., McNab R., Spratt D.A., Wilson M., and Mullany P. Prevalence of tetracycline resistance genes in oral bacteria. Antimicrob. Agents Chemother. 47 (2003) 878-882
28. WHO, 1997. The Medical Impact of Antimicrobial Use in Food Animals. Report of a WHO Meeting, Berlin, Germany, 13-17 October 1997. WHO/EMC/ZOO/97.4. WHO, Geneva.